An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom

The objective of this study was to evaluate the efficacy of fibrin adhesive made up of snake venom and bubaline fibrinogen by rat colon anastomosis. Eighty rats were randomly assigned into 2 experimental groups: GI control (anastomosis with extramucous interrupted suture) and GII (repair suture + fibrin glue). The animals were studied at the following 4 times: T0 - preoperative - T1 - 7th day postoperative, T2 - 14th day postoperative, and T3 - 21th day postoperative. The macroscopic characteristics of the intestinal segment open and closed anastomosis and the bursting strength of the anastomosed segments were observed at each of the above times. The results showed that the anastomosed segments coapted and there was no difference in the bursting strength values between the 2 groups. There was a decrease in the bursting strength values up until de 7th day postoperative in both groups with its progressive increase at the other times. Although important experimental studies using large animals are needed for a better evaluation of tissue repair processes, this adhesive may become a valuable tool for use in anastomosis.

Colecistite cronica calculosa associada a situs inversus totalis. / Chronic calculous cholecystitis associated with situs inversus totalis

E apresentado um caso de colecistite cronica calculosa em paciente de 53 anos portadora de "situs inversus totalis". Apos exploracao radiologica e sonografica a paciente foi submetida a tratamento cirurgico com remissao total de sintomatologia.Em que pese tratar-se de patologia rara a possibilidade desse diagnostico deve ser lembrada, sendo este o objetivo da presente comunicacao