Recombinant bovine basic fibroblast growth factor for the treatment of corticosteroid-dependent dermatitis: a randomized double-blind placebo-controlled trial / 中华皮肤科杂志

Objective To evaluate the safety and efficacy of recombinant bovine basic fibroblast growth factor in the treatment of corticosteroid-dependent dermatitis.Methods A randomized,double-blind,placebo-controlled clinical trial was carried out.By simple randomization,64 patients with corticosteroid-dependent dermatitis were randomly and equally divided into 2 groups:treatment group topically applying recombinant bovine basic fibroblast growth factor gel twice a day for 4 consecutive weeks,and control group topically applying the gel vehicle twice a day for 4 consecutive weeks.Clinical symptoms and signs were scored before the treatment and after 1-,2-and 4-week treatment.Meanwhile,the water content of the stratum corneum,skin sebum content and transepidermal water loss (TEWL) of the skin lesions were detected.Results Thirty-one patients in the treatment group and 30 in the control group completed the trial.The clinical symptom and sign scores in the treatment group were significantly lower at week 2 and 4 after starting treatment (1.35 ± 0.55 and 1.00 ± 0.45,respectively) than that before treatment (2.77 ± 0.43,both P ＜ 0.05),as well as lower at week 1 (2.06 ± 0.51),2 and 4 after starting treatment than that in the control group (2.43 ± 0.57,2.17 ± 0.53,1.93 ± 0.45,respectively,all P ＜ 0.05).The treatment group showed significantly increased water content of the stratum corneum at week 4 after starting treatment,significantly increased skin sebum content,but decreased TEWL at week 2 and 4 after starting treatment compared with those before treatment (all P ＜ 0.05).Compared with the control group,the treatment group showed significantly higher skin sebum content at week 2 and 4 after starting treatment,higher water content of the stratum corneum,but lower TEWL at week 4 after starting treatment (all P ＜ 0.05).No adverse reactions were observed in either of the 2 groups.Conclusion Recombinant bovine basic fibroblast growth factor is effective and safe for the treatment of corticosteroid-dependent dermatitis,and contributes to repairing and reconstructing the skin barrier function.

A new napthalenone from roots of Rumex nepalensis / 中国中药杂志

A new napthalenone, rumexone A (1), was isolated from the roots of Rumex nepalensis. The structure of 1 was elucidated by extensive spectroscopic analyses, including 1D and 2D NMR spectra and MS data. Its cytotoxic effect was evaluated using four clinically relevant human cancer cell lines, gastric carcinoma SGC7901, breast carcinoma MDA-MB-231, lung carcinoma A549, and hepatocellular carcinoma HepG2.

Chemical constituents from roots of Rumex nepalensis / 中草药

Objective: To investigate the chemical constituents from the ethyl acetate extracts in the roots of Rumex nepalensis. Methods: The compounds were isolated by using various chromatographic techniques, such as silica gel column, Sephadex LH-20 column, and semi-preparative HPLC. The structures of these compounds were determined by spectral data analyses. Results: Sixteen compounds were obtained and identified as ferulic acid (1), 7-hydroxy-5-methoxyphthalide (2), methyl 2-acetyl-3,5-dihydroxyphenylacetate (3), methylorsellinate (4), methyl p-hydroxycinnamate (5), 1-(2-Hydroxy-5-Methyl-phenyl)-ethanon (6), methyl syringate (7), 1-(2,4-dihydroxy-6-methylphenyl)-ethanon (8), 4-hydroxy-benzeneethanol (9), isovanillin (10), fallacinol (11), 7-hydroxy-2-methyl-5-methylchromone (12), 3-acetyl-2-methyl-1,5-dihydroxy-2,3-epoxynaphthoquinol (13), emodin (14), chrysophanol (15), and physcion (16). Conclusion: Compounds 12 and 13 are isolated from this plant for the first time, and compounds 1-11 are firstly isolated from the plants of Rumex L..

The application of decision tree in the research of anemia among rural children under 3-year-old / 中华预防医学杂志

<p><b>OBJECTIVE</b>To study the application of decision tree in the research of anemia among rural children.</p><p><b>METHODS</b>In the Enterprise Miner module of software SAS 8.2, 3000 observations were sampled from database and the decision tree model was built. The model using decision tree of CART bases on Gini impurity index.</p><p><b>RESULTS</b>The misclassification rate of decision tree model was, training set 21.2%, validation set 21.9%. The Root ASE of decision tree model was, training set 0.399, validation set 0.404. The area under the ROC curve was larger than the reference line. The diagnostic chart showed that the corresponding percentage was higher than the other. The decision tree model selected 9 important factors and ranked them by their power, among which mother of anemia (1.00) was the most important factor. Others were children's age (0.75), time of ablactation (0.53), mother's age (0.32), the time of egg supplementation (0.26), category of the project county (0.26), the time of milk supplementation (0.16), number of people in the family (0.13), the education status of the mother (0.12). Decision tree produced simple and easy rules that might be used to classify and predict in the same research.</p><p><b>CONCLUSION</b>Decision tree could screen out the important factors of anemia and identify the cutting-points for factors. With the wide application of decision tree, it would exhibit important application values in the research of the rural children health care.</p>

Gender analysis on prenatal care in rural areas of Xinjiang and Anhui province / 中华流行病学杂志

Objective To introduce the gender-specific view to the prenatal care and analysing the health behavior and its influencing factors. Methods Random sampling in cluster was used to select those study population and face to face interview was carried out at their residence in Xinjiang and Anhui province. Results The overall socioeconomic status of women in rural areas of Xinjiang and Anbui province was low and 93.2% of the women had education level on junior middle school or below. Politically women were less interested in these issues with only 63.1% of them ever participated in the election program or voting. In household daily life, women' s status was almost equal to or even higher than men, but men always called the shots when something important in family happened. Men still held the power of decision making. In 47.3% of the families, the husband played a decisive role on decision making. In 37.7% of the families, husbands controlled the money. When getting into expensive expenditure, 35.2% of the families having men made the final approval. When there were different opinions between the couples, husband usually made the final decision in 44.2% of all the families compared to 6.3% of the families that wives made the final decision. 73.9% of women under survey bad undergone prenatal examination and the rate on household deliveries reached 30.3%. Both gender consciousness and educational level had influenced the effect on prenatal care. Conclusion It is important to better prenatal health service in rural areas and to improve socioeconomic status on gender consciousness of women.