RESUMEN
Multi-compartment linear circulation mathematical model for targeted drug delivery systems was established on the bases of compartment theory and mass conservation theory. The function formulas of drug concentration-time in blood and target organ were established. According to this model, the drug concentration-time curve for the target organ can be plotted with reference to the data on blood. Based on the target organ drug concentration-time curve,the pharmacokinetics parameters of the target organ can also be calculated by the statistical moment. We further detected the practicability of the models by using the experimental data of drug concentration-time curve in blood and target organ of microspheres. The drug concentration-time curve in blood and in target organ predicted by mathematical model was agreed with that observed.
Asunto(s)
Humanos , Albúminas , Sistemas de Liberación de Medicamentos , Microesferas , Modelos Teóricos , FarmacocinéticaRESUMEN
Sugar-containing monomer vinylbenzylglycosylallyamide (VBG) was synthesized by vinylbenzyl amine and delta-gluconolactone in dimethylformamide(DMF) solution. The sugar-based hydrogel was prepared by free radical crosslinking copolymerization of VBG, itaconic acid (IA) and acrylamide (AM). The release properties of Aspirin from xerogels matrices and from hydrogel in different pH solutions and different concentration NaCl solutions were studied respectively. The release mechanism of Aspirin was further confirmed by evaluating the n value in Peppas equation. The results indicated that the drug release increased with the increase of pH values and with the decrease of NaCl concentration.
Asunto(s)
Humanos , Resinas Acrílicas , Química , Antiinflamatorios no Esteroideos , Química , Aspirina , Química , Preparaciones de Acción Retardada , Química , Hidrogel de Polietilenoglicol-Dimetacrilato , Química , Concentración de Iones de Hidrógeno , Succinatos , Química , Compuestos de Vinilo , QuímicaRESUMEN
Sugar-containing monomer glycosylallylamide (AAG) was synthesized by allyl amine and delta-gluconolactone in dimethylformamide (DMF) solution. The sugar-based hydrogels were prepared by free radical crosslinking copolymerization of AAG and acrylamide (AM). The release properties of Aspirin from xerogels matrices were studied and the release mechanism of Aspirin was further identified by evaluating the n value in Peppas equation. The results indicate that the drug release decreases with the increase of the sugar content of hydrogel.
Asunto(s)
Acrilamida , Química , Aspirina , Farmacocinética , Preparaciones de Acción Retardada , Gluconatos , Química , Hidrogeles , Química , Lactonas , Polímeros , QuímicaRESUMEN
The mechanism of drug release from swellable polymer was studied. The model which can explain the drug release from glassy polymer was developed by coupling drug diffusion equation and solvent diffusion equation. The effect of viscoelastic stress of polymer was also considered. The Deborah number and swelling interface number were used to describe the mechanism of drug release, especially relax controlled mechanism.