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1.
Artículo en Inglés | IMSEAR | ID: sea-167783

RESUMEN

Background: Worldwide acute ischemic stroke (AIS) is a major public health problem. Therefore, this study was undertaken to see the association of some biochemical risk factors with AIS in Bangladesh. Methodology: This study was conducted in Biochemistry department of Dhaka Medical College, Dhaka from January 2014 to December 2014. In this study, 50 patients of AIS considered as case and 50 age and sex matched healthy individuals taken as control. Blood sample was collected and tested for serum calcium and lipid profile in case and control. All the parameters then compared statistically between two groups. Results: Study showed that serum calcium was significantly lower (p= 0.001) in cases and serum TChol, TAG, LDL-C significantly higher (p= 0.035, 0.001 and 0.019 respectively) and HDL-C significantly lower (0.001) in cases compared to controls. Conclusions: This study concludes that low serum calcium level and altered lipid profile are significantly associated with AIS.

2.
Indian J Physiol Pharmacol ; 1997 Jul; 41(3): 257-62
Artículo en Inglés | IMSEAR | ID: sea-106715

RESUMEN

Calcium modulatory activity of a marine toxin has been studied employing in vitro preparations. The toxin induced contracture in rat diaphragm was not modified by denervation, d-tubocurarine and tetrodotoxin (TTX). In contrast, varying concentrations of calcium, EGTA and ryanodine inhibited the contracture significantly. The toxin produced a series of repeating contractions in vas deferens. Experiments with TTX, adrenoceptor blockers and other agents exclude a release of neuromediators or direct stimulation of post synaptic receptors to account for the rhythmic effect in vas deferens. The dependence of rhythmicity on external Ca2+ concentration and inhibiting effect of Mn2+, ryanodine and nifedipine indicate a direct activation of voltage-sensitive calcium channel. The toxin also evoked a similar pattern of response in paced atria mediated through Ca2+ influx.


Asunto(s)
Animales , Función Atrial/efectos de los fármacos , Calcio/metabolismo , Cicloparafinas/farmacología , Dinoflagelados/química , Relación Dosis-Respuesta a Droga , Masculino , Toxinas Marinas/farmacología , Contracción Muscular/efectos de los fármacos , Músculo Liso Vascular/efectos de los fármacos , Compuestos Organofosforados/farmacología , Ratas , Ratas Wistar , Conducto Deferente/efectos de los fármacos
3.
Indian J Exp Biol ; 1997 Jun; 35(6): 650-4
Artículo en Inglés | IMSEAR | ID: sea-60701

RESUMEN

An organophosphate toxin of marine origin isolated from red tide dinoflagellate P. brevis produced a dose-dependent dual effect on rat atria, i.e. positive inotropic effect at low concentrations (2.8 x 10(-8) to 8.4 x 10(-7) M) and negative inotropic and chronotropic responses at an elevated dose (4.8 x 10(-6) to 7.2 x 10(-4) M). The negative chronotropic and inotropic responses of the toxin were potentiated with physostigmine and ouabain whereas antagonized by atropine and hemicholinium-3 pretreatments and those effects remained unaltered by isoproterenol, phenylephrine and ouabain pretreatments. The results indicate that the toxin induced negative inotropic and chronotropic effects are mediated through release of acetylcholine from the nerve endings and consequent activation of muscarinic receptor. In atria exposed to guanethidine, bretylium, propranolol and tyramine tachyphylaxis, the positive inotropic response of the toxin was not modified. However, the response was antagonized by EGTA, nifedipine, ryanodine, calcium-free ringer and potentiated with caffeine and amiloride pretreatments. The results suggest that the positive inotropic effect of the toxin is mediated through Ca2+ influx and impairment of Na+/Ca2+ exchange process.


Asunto(s)
Animales , Dinoflagelados/química , Atrios Cardíacos/efectos de los fármacos , Masculino , Toxinas Marinas/toxicidad , Compuestos Organofosforados/toxicidad , Ratas , Ratas Wistar
4.
J Indian Med Assoc ; 1956 Sep; 27(6): 209
Artículo en Inglés | IMSEAR | ID: sea-96985
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