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1.
Indian J Exp Biol ; 2005 Nov; 43(11): 1042-7
Artículo en Inglés | IMSEAR | ID: sea-57426

RESUMEN

Apart from condoms and vasectomy, which have several limitations of their own, no other methods of contraception are available to men. Various chemical, hormonal, vas based and herbal contraceptives have been examined and few of them have reached the stage of clinical testing. Promising leads have been obtained from testosterone buciclate/undecanoate, alone or in combination with levonorgestrel butanoate or cyproterone acetate, RISUG, an injectable intravasal contraceptive and a few herbal products, particularly the seed products of Carica papaya. It is feasible that an ideal male contraceptive, that meets out all the essential criteria will be made available to the community in the near future.


Asunto(s)
Carica , Ensayos Clínicos como Asunto , Anticoncepción/métodos , Anticonceptivos , Anticonceptivos Masculinos/farmacología , Acetato de Ciproterona/farmacología , Dimetilsulfóxido/farmacología , Hormonas/metabolismo , Humanos , Masculino , Maleatos/farmacología , Norgestrel/análogos & derivados , Estirenos/farmacología , Testosterona/análogos & derivados , Vasectomía
2.
Indian J Physiol Pharmacol ; 1997 Jul; 41(3): 234-40
Artículo en Inglés | IMSEAR | ID: sea-107413

RESUMEN

Oral administration of 20, 40, 60, mg of dry Azadirachta indica leaf powder for 24 days resulted in decrease in the weights of seminal vesicles and ventral prostate, reduction in epithelial height, nuclear diameter and the secretory material in the lumen. Biochemically, there was a decrease in total protein, acid phosphatase activities. Seminal vesicles and ventral prostate being androgen dependent, the regressive changes histologically as well as biochemically, suggests the antiandrogenic property of the neem leaves.


Asunto(s)
Fosfatasa Ácida/metabolismo , Administración Oral , Fosfatasa Alcalina/metabolismo , Animales , Glucosa/metabolismo , L-Lactato Deshidrogenasa/metabolismo , Masculino , Hojas de la Planta/química , Plantas Medicinales , Polvos/farmacología , Próstata/citología , Ratas , Vesículas Seminales/citología
3.
Indian J Exp Biol ; 1996 Nov; 34(11): 1091-4
Artículo en Inglés | IMSEAR | ID: sea-56542

RESUMEN

Histological and biochemical changes in the testis of rats treated with the leaf powder of A. indica are reported. The pattern of recovery is also studied at 8, 16 and 24 day after withdrawal of the treatment. In the treated rats, a general reduction in the diameters of seminiferous tubule, nuclei of the germinal elements and a mass atrophy of the spermatogenic elements has been observed. The Leydig cells are found to be atrophic. Biochemically, a decrease in the protein content and the activity of acid phosphatase and an increase in the total free sugar, glycogen, cholesterol contents and the activities of alkaline phosphatase and lactate dehydrogenase have been observed. A gradual recovery is observed in both the histological and biochemical parameters after 8.16 and 24 day of cessation of the treatment. The result suggest a possible reversible antiandrogenic property of the leaves of A. indica in male albino rats.


Asunto(s)
Antagonistas de Andrógenos/aislamiento & purificación , Animales , Masculino , Extractos Vegetales/aislamiento & purificación , Plantas Medicinales , Plantas Tóxicas , Ratas , Ratas Wistar , Testículo/efectos de los fármacos , Factores de Tiempo
4.
Indian J Exp Biol ; 1995 Oct; 33(10): 725-9
Artículo en Inglés | IMSEAR | ID: sea-55966

RESUMEN

The histological and biochemical changes in the caput and cauda epididymis of albino rat treated with 20, 40 and 60 mg dry powder of the leaves of A. indica per day for 24 days are reported. In the treated rats, the height of the epithelium and the diameter of the nucleus in both the regions were reduced. The lumen of the caput was packed with lymphocytes. Biochemically, a decrease in the protein content and acid phosphatase activity and an increase in the alkaline phosphatase and lactate dehydrogenase activities were observed in both the regions. The effect was dose dependent. Further, serum testosterone concentration in the higher dose treated animals decreased significantly. The results suggest a possible antiandrogenic property of the leaves of A. indica.


Asunto(s)
Animales , Epidídimo/efectos de los fármacos , Masculino , Medicina Ayurvédica , Hojas de la Planta , Ratas , Ratas Wistar , Árboles
5.
Indian J Exp Biol ; 1990 May; 28(5): 421-6
Artículo en Inglés | IMSEAR | ID: sea-55994

RESUMEN

Dry leaf powder of A. paniculata, when fed orally to male albino rats, at a dose level of 20 mg powder per day for 60 days, resulted in cessation of spermatogenesis, degenerative changes in the seminiferous tubules, regression of Leydig cells and regressive and/or degenerative changes in the epididymis, seminal vesicle, ventral prostate and coagulating gland. There was reduction in the weight and fluid content of the accessory glands. The treatment also resulted in accumulation of glycogen and cholesterol in the testis, and increased activities of lactate dehydrogenase in testis and alkaline phosphatase in testis and ventral prostate. The results suggest antispermatogenic and/or antiandrogenic effect of the plant.


Asunto(s)
Antagonistas de Andrógenos , Animales , Anticonceptivos Masculinos , Fertilidad/efectos de los fármacos , Genitales Masculinos/efectos de los fármacos , Masculino , Plantas Medicinales , Ratas
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