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Indian J Physiol Pharmacol ; 1975 Apr-Jun; 19(2): 76-80
Artículo en Inglés | IMSEAR | ID: sea-106844

RESUMEN

Six new substituted acylamides, chemically related to lignocaine were studied for local anaesthetic activity and toxicity in mice, frogs and guinea pigs. Only one of these compounds, w-pyrrolidino 2, 3, 5, 6 tetramethyl acetanilide was found to possess potency comparable to lignocaine with a slightly higher therapeutic index. Study of the S.A.R. of this group indicated that by removal of two methyl groups at position 3 and 5 in the above compound, a local anaesthetic with greater potency than lignocaine may be obtained. Further exploration of the potentialities of a compound having pyrrolidine group as a part of basic side chain is indicated.


Asunto(s)
Acetanilidas/análogos & derivados , Anestesia de Conducción , Anestesia Local , Animales , Anuros , Córnea , Dietilaminas/toxicidad , Dimetilaminas/toxicidad , Cobayas , Dosificación Letal Mediana , Lidocaína/análogos & derivados , Ratones , Morfolinas/toxicidad , Piperidinas/toxicidad , Propilaminas/toxicidad , Pirrolidinas/toxicidad , Relación Estructura-Actividad , Cola (estructura animal)
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