Tissue-type plasminogen activator, plasminogen activator. Inhibitor in stressed newborns

Stressed newborns have an increased prevalence of thrombotic disease. Estimation of tissue-type plasminogen activator [tPA] antigen and activity, plasminogen activator inhibitor [PAI] antigen and activity, fibrinogen level, prothrombin time [PT] and partial thromboplastin time [PTT] were determined in fifteen stressed and fifteen normal neonates. The stressed group showed significantly higher levels of [tPA] antigen and activity. Also [PAI] antigen and activity were significantly elevated in stressed neonates. On the other hand fibrinogen concentration, showed in significant decrease in stressed neonates. Prothrombin time and partial thromboplastin time showed insignificant prolongation in stressed babies. This study proved that stressed neonates increase [tPA] and activate lytic system. However, the activity is suboptimal due to associated increase in [PAI]

Fibronectin, laminin and complement C3 estimation in chronic renal failure before and after hemodialysis: a possible role in the pathogenesis

Nineteen patients with chronic renal failure [nine cases with cancer bladder and ten cases with other etiological causes] were studied. Plasma fibronectin, laminin and C3 were checked before and after hemodialysis. The plasma fibronectin, laminin and C3 were significantly reduced in chronic renal failure [CRF] before hemodialysis than in the controls, while fibronectin was significantly reduced in patients with CRF due to cancer bladder after hemodialysis. These changes may be a possible cause of rapid invasiveness of cancer bladder with metastatic formation and repeated infection in patients with CRF. The results were discussed