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IJML-International Journal of Medical Laboratory. 2015; 2 (1): 34-40
en Inglés | IMEMR | ID: emr-186343

RESUMEN

Background and Aims: multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor [FLT3] mutation has been proved as a determining factor in leukemic patients; the goal of this study was to find association of FLT3 internal tandem duplication [ITD] and FLT3 tyrosine kinase domain [TKD] mutations with multiple myeloma


Materials and Methods: this case-control study was conducted on 60 paraffinembedded bone marrow biopsies [30 multiple myeloma and 30 normal bone marrow specimens] in the pathology departments of Ghaem and Imam Reza hospitals in Mashhad. After sections preparation, DNA was extracted and two PCR reactions were set up for detection of FLT3/ ITD and FLT3/TKD mutations


Results: the Mean age of samples was 64+/-10 years. No FLT3 mutations were detected in multiple myeloma patients


Conclusion: our findings showed that occurrence of FLT3 mutations seem unusual in multiple myeloma

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