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@#Introduction: Idiopathic generalised epilepsy (IGE) refers to a group of epilepsies resulting from the activation of neurons in the whole brain. This study aimed to evaluate the metabolite changes in thalamus as diagnostic biomarkers in IGE patients compared to healthy individuals using magnetic resonance spectroscopy (MRS) technique. Methods: The MRS was performed on 35 IGE patients (26 women and 11 men) with average age of 32 (ranged from 18 to 43) and 35 healthy individuals (13 women and 22 men) with average age of 31 (ranged from 21 to 50) as the control group. The levels of N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) were measured using MRS. The NAA/Cr and NAA/Cho ratios were calculated for all participants. These values were statistically compared using t-test between the groups. Results: The NAA had significant lower values in IGE patients, 9.6 (SD = 0.8) and 9.9 (SD = 0.7) for right and left thalamus, respectively, compared to 10.9 (SD = 0.9) and 10.7 (SD = 0.9) in control group. The Cr values in the left side of thalamus were significantly higher in IGE patients (6.7 [SD = 0.8] versus 5.8 [SD = 0.5]); however, there was no difference in right thalamus. Measurements showed no difference for amounts of Cho between the groups in both sides of thalamus. The NAA/Cr ratio was 1.48 (SD = 0.14) and 1.48 (SD = 0.16) for right and left thalamus, respectively, in IGE patients in comparison with 1.83 (SD = 0.2) and 1.86 (SD = 0.26) in controls. There was no meaningful variation between the NAA/Cho ratio of the right and left thalamus among the groups. Conclusion: Thalamic NAA, Cr and NAA/Cr ratio values in IGE patients showed statistical differences compared to healthy individuals. Evaluating metabolites variations in thalamus using MRS is suggested for differentiating IGE patients from healthy individuals.
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Background: Today, the quality of life [QoL] studies have an important role in public health care, especially among the old adults suffering from chronic diseases such as diabetes. Diabetes and its complications can widely affect various aspects of QoL. Therefore, the present study aimed to assess diabetic patients' QoL and identify the factors that affect it
Methods: A cross-sectional study was conducted on 593 randomly selected diabetic patients aged 60 years and above who were admitted in 13 diabetes clinics in Shiraz, Iran, in 2014. Diabetes Quality of Life-Brief Clinical Inventory [DQOL-BCI] questionnaire was used to assess the quality of life in these patients. Univariate and multivariate linear regression analyses were performed, using Stata software, version 12, to identify the predictors of DQoL
Results: The participants' mean DQoL score was 41.8+/-6.2 with a mean age of 66.2+/-6.0 years. Multivariate linear regression analyses revealed that FBS level [115-180 mg/dL: P=0.05; above 180 mg/dL: P=0.02] and duration of diabetes [4-9 years: P=0.06; above 9 years: P=0.002] were two important clinical predictors of DQoL
Conclusion: This study demonstrated a relationship between clinical and socio-demographic factors and diabetic patients' QoL. Considering these related variables could lead to effective control of diabetes complications and improvement of the patients' QoL
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OBJECTIVES: The survival rate of thalassemia patients has not been conclusively established, and the factors associated with survival remain unclear. This study aimed to determine the survival rate of thalassemia among patients in southern Iran and to identify the factors associated with mortality from thalassemia. METHODS: This retrospective cohort study was conducted based on a retrospective review of the medical records of 911 beta-thalassemia patients in 2014. Data analysis was conducted using the Kaplan-Meier method and Cox regression analysis. RESULTS: Overall, 212 patients (23.3%) died, and 26.8% had thalassemia intermedia. The 20-year, 40-year, and 60-year survival rates were 85%, 63%, and 54%, respectively. Both crude and adjusted analyses found that education, marital status, ferritin levels, and comorbidities were related to mortality. CONCLUSIONS: Sociodemographic and hematological factors were found to be significantly associated with the survival rate of thalassemia. Addressing these factors may help healthcare providers and physicians to provide the best possible care and to improve the survival rate.