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1.
Iranian Journal of Allergy, Asthma and Immunology. 2006; 5 (3): 143-145
en Inglés | IMEMR | ID: emr-137881

RESUMEN

In this case report we will describe a rare association between anhyrotic ectodermal dysplasia [AED] and immunodeficiency and autoimmunity [in our case: Idiopathic Thrombocytopenic Purpura [ITP] and Crohn disease]. AED is a rare congenital disorder characterized by sparse hair, abnormal teeth and anhidrosis due to lack of eccrine glands. The survey of 87 cases with [AED] revealed only one Irritable Bowel Disease [IBD]. AED has only two relevancies with immunodeficiency: [EDA-ID: Ectodermal Dysplasia Anhyrotic with Immunodeficiency] and APE-CED [Autoimmune polyendocrinopathy, Candidiasis and Ectodermal Dysplasia] that in our case EDA-ID is strongly suspected

2.
Iranian Journal of Allergy, Asthma and Immunology. 2006; 5 (4): 183-186
en Inglés | IMEMR | ID: emr-167354

RESUMEN

Magnesium [Mg] is the second most abundant intracellular cation and is involved in numerous physiological functions, including protein folding, intracellular signaling and enzyme catalysis. It has been shown that magnesium deficiency exacerbates pulmonary airways hyperreactivity. Several studies suggest that magnesium level has no effect on asthma but others had shown a contributory effect. Because of its intracellular abundance, the aim of this study was to determine if there was any difference in plasma and intracellular Mg concentrations of children with acute asthma compared to non asthmatic children. Twenty nine patients with acute asthma aged 2 to 11 years admitted to the emergency department of hospital and 37 non asthmatic children with the same age were included in our study. O.5 mL of heparinized whole blood samples of patients who were meeting inclusion criteria at the onset of admission with bronchoconstriction and before using any medication was drawn and it was immediately sent to the laboratory. Plasma and erthrocytes were separated and stored at -20C and later their Mg levels were quantified with atomic absorption spectrophotometry method. The average plasma and intracellular magnesium levels in patients were [0.79 +/- 0.098 mmol/L] and [1.17 +/- 0.27 mmol/ L] respectively. Results of 37 non asthmatic persons [plasma [0.85 +/- 0.1 mmol/L] and erythrocytes [1.33 +/- 0.21 mmol/ L]] showed that there was no significant difference between plasma Mg levels in two groups [p 0.06] but intracellular magnesium level was significantly lower [p 0.03] in patients group. These results indicate that intracellular Mg level may be a more accurate method to assess Mg level in patients with asthma. Hence, determination of Mg concentration in erythrocytes may be used in evaluation of asthma pathophysiology. There are recommendations for using intravenous Mg sulfate in acute asthma, and this study supports the rational for using it in emergency departments for acute severe asthma

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