Asunto(s)
Animales , Antidepresivos/farmacología , Bupropión , Catalepsia/prevención & control , Femenino , Haloperidol , Masculino , Morfina , Propiofenonas/farmacología , RatasRESUMEN
The effects of ranitidine (2 mg/kg, po) and phenylbutazone (100 mg/kg po) have been studied in different models of acute and chronic inflammation in rats. Ranitidine showed significant anti-inflammatory activity in the four models used. This observation supports the concept that histamine has a pro-inflammatory role that is mediated via stimulation of H2-receptors.
Asunto(s)
Enfermedad Aguda , Animales , Antiinflamatorios , Artritis/tratamiento farmacológico , Artritis Experimental/tratamiento farmacológico , Carragenina , Enfermedad Crónica , Femenino , Granuloma/tratamiento farmacológico , Inflamación/tratamiento farmacológico , Masculino , Peritonitis/tratamiento farmacológico , Ranitidina/uso terapéutico , Ratas , Ratas Endogámicas , TrementinaAsunto(s)
Adulto , Epinefrina/farmacología , Femenino , Histamina/farmacología , Humanos , Masculino , Pirilamina/farmacología , Ranitidina/farmacología , Receptores Histamínicos/efectos de los fármacos , Receptores Histamínicos H1/efectos de los fármacos , Receptores Histamínicos H2/efectos de los fármacos , Pruebas CutáneasAsunto(s)
Animales , Catarata/fisiopatología , Cabras , Humanos , Cristalino/fisiopatología , Preservación de Órganos/métodos , Conejos , Ratas , Factores de TiempoRESUMEN
Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.