RESUMEN
A six-day-old girl, born to normal non-consanguineous parents presented with mask like facies with a small mouth giving a ‘whistling’ appearance. Other dysmorphic features include deep set eyes, broad nasal bridge, long philtrum and ‘H’ shaped cutaneous dimple on the chin. There was congenital windmill vane hand position and severe talipes equinovarus deformity. The above features are characteristic of Freeman-Sheldon syndrome also known as Whistling Face syndrome. Ultrasound scanning during 8th month of the pregnancy showed the fetus to have facial abnormality and bilateral clenched hand and talipes with extension contractures of knees. Provisional diagnosis of FSS was made which was confirmed after the birth. Thus all cases of Arthrogryposis during prenatal scan should be carefully looked for the facial abnormality in the fetus.
Asunto(s)
Artrogriposis/diagnóstico , Artrogriposis/genética , Artrogriposis/fisiopatología , Proteínas del Citoesqueleto/genética , Facies , Femenino , Deformidades del Pie/complicaciones , Deformidades del Pie/diagnóstico , Humanos , Recién Nacido , Rodilla/fisiopatología , Embarazo , Diagnóstico Prenatal , SíndromeRESUMEN
The expression and distribution of keratins within different layers of enamel organs of embryonic and neonatal rats studied by using indirect immunoperoxidase and immunofluorescent techniques in paraffin-embedded tissues employing specific antibodies revealed Keratin positivity in odontoblastic layer, oral epithelium and dental lamina in primitive stages; other odontogenic tissues showed negative reaction.
Asunto(s)
Animales , Biomarcadores , Embrión de Mamíferos , Técnica del Anticuerpo Fluorescente , Técnicas para Inmunoenzimas , Inmunohistoquímica , Queratinas/metabolismo , Odontogénesis/fisiología , Ratas , Ratas WistarRESUMEN
Fractionation of methanolic extracts of air dried aerial parts of Parthenium resulted in the isolation of a toxic constituent which was identified as parthenin, the major sesquiterpene lactone from the weed. The LD50 (minimal lethal dose required to cause 50% mortality) for parthenin in rats was 42 mg/kg body weight. When [3H]-parthenin was given orally or by intravenous administration, radioactivity appeared in the milk of lactating laboratory and dairy animals. Tissue distribution of radioactivity revealed that maximum label was detectable in kidneys.