[Effect of hydroalcoholic extract of chevil [ferulago angulata] on glucose and lipid in diabetic male rats]

Introduction: Diabetes is a metabolic disease characterised by chronic hyperglycemia. Considering the properties antioxidant of the Chevil plant compounds, this study performed to determine the effect of hydroalcoholic extract of Chevil on serum glucose and lipid in diabetic male rats

Materials and Methods: In this study, 54 male Wistar rats weighing 200-250 g were divided into 6 groups [n=9 each] and studied for 4 weeks. The groups were as follows: Control, diabetic, diabetic groups treated 200, 400 and 800 mg/kg body weight of the Chevil extract, respectively and the diabetic rats treated with 150 mg/kg body weight of metformin. At the end of study, FBS, Cholesterol, Triglycerides, HDL-C, and LDL-C levels were measured. Results were analyzed by oneway ANOVA

Results: Findings showed a significant reduction [P<0.05] of FBS in all groups with three doses of the extract, 26%, 59.3%, 69.4% respectively], Triglycerides [at 200 and 400 mg/kg of the extract respectively 16.1% and 34.1%], Cholesterol [800 mg/kg of the extract, 20.9%], LDL-C in all three doses of the extract, 25.9%, 49.1% and 53% respectively and a significant increase [P<0.05] in HDL-C in all three doses of the extract, 32.6%, 36.4% and 37.1% respectively compared to the control group was observed in diabetic rats treated with Chevil

Conclusion: The results of this study showed that Chevil extract reduces blood sugar and improves blood lipid profiles in diabetic rats

[Comparison between the effects of hydroalcoholic extract of dill and statins on lipid profile]

A transient increase of blood concentration of lipids after meal is able to increase the risk of atherogenesis. This study aimed to determine the effects of Anethum graveolens L. [dill] consumption on atherosclerosis and hepatic risk factors. In an experimental study, 32 male New Zealand rabbits were randomly allocated to four groups to receive normal diet, a diet containing 1% cholesterol, a diet containing 1% cholesterol plus 200 mg/kg dill powder, and a diet containing 10 mg/kg lovastatin. Risk factors of atherosclerosis including glucose, total cholesterol [TC], triglyceride [TG], apolipoprotein B [ApoB], alanine aminotransferase [ALT], aspartate aminotransferase [AST], low density lipoprotein cholesterol [LDL-C], nitrite, nitrate, fibrinogen, and factor VII were measured and compared between different groups.Consumption of dill caused a significant reduction in glucose compared to the hypercholesterolemic diet group. Dill powder significantly decreased LDL-C, TC, AST, ALT, and fibrinogen. No significant differences were found between dill group and hypercholesterolemic diet group in ApoB, factor VII, nitrite, and nitrate. According to our findings, postprandial consumption of dill may have beneficial effects on atherosclerosis and hepatic risk factors

[ beneficial effects of vaccinium myrtilus L. intake on atherosclerosis risk factors in male New Zealand rabbits]

The increase in the blood concentration of lipids after meals has a significant effect on induction of atherosclerosis. Vaccinium myrtilus has an antioxidant activity, and in this study, we aimed to determine the effects of this plant on atherosclerosis risk factors. In an experimental study, 24 male New Zealand rabbits were randomly designated into three groups of 8 rabbits: Group 1, normal diet; Group 2, a diet containing 1% cholesterol; and Group 3, a diet containing 1% cholesterol and 2% Vaccinium myrtilus powder. The blood glucose, total cholesterol [TC], triglyceride [TG], apolipoprotein B [ApoB], Alanine aminotransferase [ALT], Aspartate aminotransferase [AST], LDL-C [low density lipoprotein], nitrite, nitrate, fibrinogen, and factor VII, which are considered as atherosclerosis risk factors, were measured before the experiment and 3 hours after feeding. The data were analyzed using One-Way Analysis of ANOVA. The P-values below 0.05 [P<0.05] were considered as significant. Consumption of Vaccinium myrtilus significantly decreased the concentrations of LDL-C, TC, aminotransaminases [AST, ALT], ApoB, and fibrinogen compared to the hyper-cholesterolemic diet group [P<0.05]. However, there were no significant differences was found between the group taking Vaccinium myrtilus and hyper-cholesterolemic diet group with regard to the serum glucose, TG, factor VII, nitrite, and nitrate [P>0.05]. The results of this study show that acute consumption of Vaccinium myrtilus might have a protective effect on some atherosclerosis risk factors

[Association of [Ile462Val in genetic polymorphisms CYP1A1] and uterine leiomyoma risk in women in Charmahal va Bakhtiari, I.R. Iran]

Uterine leiomyoma is a benign solid tumor of smooth muscle and the most common type of gynecological tumor. It occurs in approximately 25-30% of women over 30 years old. Studies have shown that the growth of uterine leiomyma was related to estrogen, cousidering the effect of CYP1A1 gene in estrogen metabolism, this study was done to evaluate the association of CYP1A1 [Ile462Val] polymorphisms with uterine leiomyoma in Charmahal va Bakhtiari women. In this case - control study, 156 non menopause women with the age ranges of 17-57, with clinically diagnosed uterine leiomyoma and 151 healthy normal subjects were investigated. The Ile462Val [AG] Polymorphism between the two groups [P=0.306]. The results of this study demonstrated that the CYP1A1Ile462Val polymorphism was not correlated with an increased risk of uterine leiomyoma in the study population

[Effect of alcoholic extract of Tanacetum parthenium on acute pain in rat]

Background: The use of medicinal plants to reduce pain is important. Tanacetum parthenium has been introduced as an analgesic agent in traditional medicine and is widely used to relieve neuropathic pain and headache

Objective: The aim of this study was to investigate the analgesic effect of Tanacetum parthenium ethanolic extract on acute pain

Methods: This study was carried out on 100 male mice weighing 30-35g. Acute pain was investigated using a hot plate test with set point 48 [degree]C and cut off time of 30 seconds. In this experiment 100 mice were divided into 10 groups as follows: 1] control group; groups 2-6 received 10, 20, 30, 40 and 80 mg/kg of alcoholic extract, respectively; group 7 received 100 mg /kg ibuprofen; group 8 received 0.5 mg /kg morphine; group 9 received 0.5 mg/kg naloxone; and finally group 10 received naloxone and extract. Ethanolic extract of aerial parts was prepared by maceration method and later its analgesic effect was studied at different doses of 10, 20, 30, 40, and 80 mg/kg, i.p. The effect of ethanolic extract and fractions were compared with the analgesic effect of morphine and ibuprofen as standard analgesic drugs. Naloxone was used to study the opioid system. Data were analyzed by SPSS using Kruskal Wallis test

Findings: Results obtained from this study showed that the ethanolic extract of Tanacetum parthenium produced an analgesic effect [P<0.05] at two doses of 30 and 40 mg/kg, i.p. The analgesic effect of extract was not lower than that of morphine [10 mg/kg, i.p.], and ibuprofen [100 mg/kg] [P<0.05]. Application of naloxone showed no inhibition on analgesic effect of the extract [P<0.05]

Conclusion: The analgesic effect of Tanacetum parthenium was also comparable to that of morphine and ibuprofen, both well known for their analgesic effects. Further investigations to establish a link between the analgesic effect of Tanacetum parthenium and particular phytochemicals, are recommended

[Effects of Sesamum indicum L. on fibrinogen and factor 7 in hypercholesterolemic rabbits]

Background and aim: Enhancement of blood factor 7 or fibrinogen is considered as cardiovascular risk factors. This study was, therefore, aimed to evaluate the effects of Sesamum indicum seed and oil on fibrinogen and factor 7 in hypercholesterolemic rabbits

Methods: In an experimental study, 32 New Zealand rabbits were randomly designated into 4 groups of 8 and were fed for 60 days as following: normal diet, hypercholestrol [1%] diet, hypercholestrol [1%] diet+10% sesame seed, hypercholestrol [1%] diet+5% sesame oil. At the beginning and 60 days after the start of the study, the blood fibrinogen and factor 7 were measured and compared in different groups

Results: There was no difference for fibrinogen and factor 7 in different groups at the start of the study, however, the blood fibrinogen and factor 7 were increased in hypercholesterolemic group compared to normal diet group [P<0.05]. The amounts of blood fibrinogen and factor 7 were decreased in hypercholesterol+sesame seed and in hypercholesterol+sesame oil groups compared to hypercholesterol diet group [P<0.05]

Conclusion: Sesame seed and oil may have beneficial effects on cardiac function by decreasing blood fibrinogen and factor 7 as cardiovascular risk factors

[ effect of hydroalcoholic extract of Zizipus vulgaris L. on burn healing]

Traditionally, burn wound healing activities have been claimed for Zizipus vulgaris L, but there is not any evidence in literature for this effect of the plant. Therefore, this work was carried out to investigate the effect of hydroalcoholic extract of Zizipus vulgaris L. on burn healing. In an experimental study burn wounds were made by placing a hot plate with a surface area of 1.5 cm[2] for 10s on the back of animals. 40 mice were designated in 4 groups. Animal were treated with vehicle or test substance two times per day for 21 days. The first group received nothing, second group Vaseline. Third and fourth group 1% and 10% Jujba ointment two times/day, respectively. Percent of burn wounds healing and total time required for complete healing were evaluated. Results showed that 1% dose of Jujuba extracts had significant burn wound healing compared to control group [P<0.01]. Zizipus vulgaris L. has considerable healing effect on burn wounds and its usage might be beneficial in these patients

frequency of hearing loss etiology among deaf students in Chaharmahal va Bakhtiari province, Iran, 2008-2009

Hearing loss is the most common sensory disorder in human and has a profound economic and social impact in the modern world. The etiology of deafness can be due to genetic or non-genetic causes in origin. Genetics etiology of hearing loss is classified into syndromic and nonsyndromic. The aim of this study was to determine the etiology of deafness in deaf students in Chaharmahal va Bakhtiari province, Iran. Altogether, 265 patients with mild to profound hearing loss were contributed in this descriptive study. The subjects were deaf pupils from the schools of Chaharmahal va Bakhtiari province. Age of the students was between 6 and 22 years. Medical history, pedigree information and demographic data were collected using a questionnaire. Each patient underwent general and otoscopic examinations and also pure-tone audiometery. Otoacoustic emissions, as well as auditory brainstem response testing were performed in patients suspected to neural hearing loss. Consanguineous marriages were detected in 67.2% of deaf families, from which first cousins marriage was the most common with the rate of 78.1% of overall consanguinity. Our study revealed that up to 98.8% of genetic deafness cases were in autosomal recessive mode. We found sensorineural hearing loss as a predominant type of deafness in 97.8% of the population studied. Moreover, hearing loss with genetic in origin was found as the most frequent deafness etiology with a rate of 60.8% and then acquired and idiopathic hearing loss are in next step, respectively. We found syndromic etiology in 4.2% of the students and ophthalmic problems were the most dysfunction accompanied with hearing loss. This data highlight the importance of consanguine marriage in the studied population. We found a very high rate [67.2%] of consanguine marriage, which can be the main cause of congenital deafness