Synthesis of some new 9-substituted acridines of possible Antimicrobial activity

A series of 9-substituted acridines has been synthesized utilizing 3-[9-acridinyl] propanoylhydrazine, 9-[4-aminophenyl] acridine [II] and 9-chloromethylacridine [III] as starting materials. The hydrazones Ic and Id as well as the Schiff bases IIa-IIc were produced via condensation of the acid hydrazide Ib or the amine II with different aldehydes. The acid hydrazide Ib was also reacted with some acid anhydride to afford the pyridazinone derivatives Ie and If. In addition, 9-chloromethylacridine [III] was reached with glycine, sulfanilamide or sulfadiazine to give the corresponding N-alkylated derivative IIIa-IIIc. The structure of the synthesized products was substantiated by spectroscopic data and elemental analyses. Some of the prepared compounds were found to possess antimicrobial activity

Salvation as a new means for separation of e and z forms of aromatic schiff bases

Several Schiff bases I-XI were synthesized by reaction of o- aminophenol or o-aminobenzoic acid and variously substituted benzaldehyde. The rate of condensation was affected by the nature and position of substituents in the phenylimine or benzylidene group. The E and Z forms of each prepared compound were separated by solvation. The structure of each form was established by IR, PMR and elemental analysis. The antibacterial activities of the prepared anils differed from one isomer to the other

Flourimetric and colorimetric determination of 1-amino-2-propanol, ethanolamine, benzocaine and 4-amino benzoic acid

A convenient and simple fluorimetric method for the determination of 1-amino-2-propanol, ethanolamine, benzocaine and 4-amino benzoic acid has been developed. The method depends on the reaction of the previously mentioned amines with m-hydroxy benzaldehyde to form highly fluorescent Schiff bases in absolute alcohol at 70C for 20 minutes. On the other hand, these primary amine-containing compounds were determined by colorimetric method. The Schiff bases obtained possess yellow with maximum absorption wave length range of 460-480 nm. Beer's law obeyed in the range of 0.1-5 mg/ml. The effect of pH, temperature, time and solvent of the reaction for both fluorimetric and colorimetric methods were studied and optimized

Separation of n-substituted benzylidene-p-aminobenzoic acid conformers of biological activity

Several aldimines were produced by the reaction of p-aminobenzoic acid and certain substituted benzaldehydes. The products I-XII were resolved into their conformers via formation of solvates in a definite volume of appropriate solvent. The solvent differed in their volatility at room temperature. The structure of each compound was established by elemental analysis and IR, PMR spectral data. The antibacterial activities for all prepared compounds were examined

Synthesis and chelating properties of tartaric acid diamide derivatives

Diamide of L[+]-tartaric acid derivatives were prepared by the reaction of di-O-acetyl-L [+]- tartaric acid anhydride or di-O-benzoyl-L [+]-tartaric acid anhydride or methyl ester of L[+]-tartaric acid with isopropanolamine or ethanolamine. The structure of the compounds was confirmed by spectroscopic data and microanalysis. The compounds, especially di-O-acetyl derivatives, reacted with metal ions [Cu++, Ca++ and Mg++] in methyl alcohol at room temperature producing crystalline, water soluble products. The chelating behavior of the compounds toward some metal ions was studied by spectrophotometric and IR methods. The chelating properties of the compounds were highly affected by the type of O-substitute groups in tartaric acid derivatives