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Indian J Exp Biol ; 1992 Aug; 30(8): 690-5
Artículo en Inglés | IMSEAR | ID: sea-57138

RESUMEN

Pathogenesis of a murine herpes virus was investigated in inbred strains (BALB/c, CBA, AKR and C57BL/10) of mice. After intranasal inhalation, virus was found to replicate primarily in the lungs, followed by haematogenous spread to the target organs (adrenal glands and ganglia). AKR (H-2k) were found to be most susceptible to virus infection while CBA (H-2k) mice appeared to be relatively resistant. Infection of B-cell depleted BALB/c mice resulted in detection of lower lung virus titres in B-cell depleted animals as compared to normal intact mice. Moreover, 3 of 12 normal mice in untreated group died of virus infection while deaths did not occur in the B-cell depleted group. Results of T-cell subset depletion experiments in BALB/c mice revealed maximum mortality in the group depleted of both Lyt-2+ and L3T4+ subpopulations. Infectious virus titres were also higher in lungs of T-cell depleted animals.


Asunto(s)
Animales , Linfocitos B/inmunología , Femenino , Herpesviridae/patogenicidad , Infecciones por Herpesviridae/inmunología , Depleción Linfocítica , Ratones , Ratones Endogámicos/inmunología , Subgrupos de Linfocitos T/inmunología
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