RESUMEN
OBJECTIVE@#To investigate the role of Keap1-Nrf2-ARE pathway in laryngeal carcinoma occurrence and development.@*METHOD@#Thirty-five laryngeal carcinoma samples and para-carcinoma tissues were taken from the patients who accepted operation treatment in our hospital from Feb 2012 to Sep 2013. The expression levels of Nrf2 and Keap1 were detected in 35 cases of laryngeal carcinoma with SP immunohistochemical methods. The data were analyzed by the SPSS 13.0 statistical software.@*RESULT@#The expression of Nrf2 in the 35 cases of laryngeal carcinoma was 77.14%, which in the para-carcinoma tissues was 8.57%, the difference between these two groups was statistically significant (P 0.05).@*CONCLUSION@#Keap1-Nrf2-ARE pathway may play an important role in progression of laryngeal squamous cell carcinoma.