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Introduction: Bleeding and thrombotic complications arehigh possibility in CKD. The present study was conductedto evaluate the platelets indices in patients on haemodialysishaving Type 2 diabetes with CKD as compared to diabeticpatients without CKD.Material and methods: 100 patients of ckd with diabetesand 100 patients of diabetes without ckd were studied over aperiod of seven months. The coagulation profile and plateletindices were compared. The coagulation profile and plateletindices were also compared in ckd patients before and afterdialysis.Results: Increase in platelet indices mainly MPV and PlateletDistribution Width (PDW) with significant p-value 0.003 and0.005 respectively in study group. PT and APTT both wereincreased in study group with significant p-value of 0.003.Platelet count improved but MPV and PDW values wereslightly decreased with p-value < 0.005. PT showed not muchdifference whereas APTT values were higher compare to postdialysis with p-value<0.007.Conclusion: Basic coagulation profile like PT and APTT andMPV can predict long term complications of diabetic plateletson haemodialysis and these should be monitored in CKDpatients.
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Introduction: Type 2 diabetes mellitus is progressive loss ofglycemic control over a period of time. So the purpose of thepresent study was to evaluate the effectiveness and safety ofthe Sitagliptin as an ‘add-on’ to the ongoing drug therapy inpatients with Type 2 Diabetes Mellitus (T2DM).Material and Methods: It was a randomized, retrospectivepopulation based cohort study done in 259 patients for 36weeks from July’12 – March’13. Patients were randomlydivided into 2 groups. In 1st group, sitagliptin was added andno ongoing drug was withdrawn while in 2nd group sitagliptinwas added and dose of ongoing therapy was reduced to half.Results: The primary efficacy endpoint was reduction inglycated haemoglobin (HbA1C), fasting blood sugar, and 2hour post prandial blood sugar evaluated after 4, 8, 12, 18 and36 weeks. A better glycemic control was observed in 1st groupthan 2nd. Sitagliptin was well tolerated without side effects.Conclusion: Addition of Sitagliptin 100mg once daily as‘add-on’ drug therapy was well tolerated with significantglycemic control in T2DM after 36 weeks.
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Introduction: Thrombocytopenia is common haematologicalfinding with different specific etiologies. The aim ofpresent study was to find clinicopathological correlation ofthrombocytopenia in adults by causes, severity and clinicalpresentation.Material and Methods: This was a cross sectional studydone for a period of 6 months. After clinical profile laboratorydata and complications of patients with a platelet count of lessthan 1,50,000 were analyzed and tabulated.Results: The total sample size was 135 with 95(70.37%) malesand 40 (29.63%) females. Out of 135 patients, 32(23.70%)were diagnosed dengue. Malaria was found in 20% patients.Most cases were presented with fever(56%) followed bybodyache (40.74%), joint pain(33.33%), bleeding (17.03%)and hepatosplenomegaly(15.55%).Conclusion: Infectious diseases were the most common causeof thrombocytopenia out of which dengue was commonestfollowed by malaria and typhoid. Early recognition anddiagnosis of cause of thrombocytopenia can avoid bleedingmanifestations and serious complications.