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Artículo en Inglés | IMSEAR | ID: sea-140101

RESUMEN

Context: Oxidative stress has been implicated in the pathogenesis of lichen planus, and a lower level of lycopene has been reported in erosive and atrophic oral lichen planus (OLP) patients. However, its efficacy in the management of OLP has not been reported. Aim: This study was designed to assess the efficacy of systemic lycopene in the management of OLP. Settings and Design: This prospective, randomized, double-blind, placebo-controlled study was done in the Oral Medicine Department of a postgraduate teaching dental hospital in India. Materials and Methods: Thirty symptomatic OLP patients, randomly divided into two groups of 15 each, were administered lycopene 8 mg/day and an identical placebo, respectively, for 8 consecutive weeks. Burning sensation using visual analogue scale and overall treatment response using Tel Aviv-San Francisco scale were recorded at every visit. The data obtained were analyzed statistically using Wilcoxon Rank test, Mann-Whitney and Fischer's Exact test. Results: A higher (84%) reduction in burning sensation was seen in lycopene than in the placebo group (67%). All 15 (100%) patients in the lycopene group showed 50% or more benefit and 11 (73.3%) patients showed 70-100% benefit, while this number was only 10 and 4 (26.7%), respectively, in the placebo group. Conclusion: Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis.


Asunto(s)
Adolescente , Adulto , Anciano , Antioxidantes/administración & dosificación , Antioxidantes/uso terapéutico , Carotenoides/administración & dosificación , Carotenoides/uso terapéutico , Método Doble Ciego , Femenino , Estudios de Seguimiento , Humanos , Liquen Plano Oral/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Estrés Oxidativo/efectos de los fármacos , Dimensión del Dolor , Placebos , Estudios Prospectivos , Inducción de Remisión , Resultado del Tratamiento , Adulto Joven
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