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1.
Acta Physiologica Sinica ; (6): 375-378, 2002.
Artículo en Chino | WPRIM | ID: wpr-318982

RESUMEN

Using whole cell patch clamp, the effects of angiotensin II (Ang II) on the current L-type calcium channel (I(Ca.L)) were observed in guinea pig isolated ventricular myocytes under simulated ischemia condition, which was realized through hypoxia, glucose deficiency, high lactic acid and acidosis. The results showed that, under the condition of simulated ischemia, the peak of I(Ca.L) was reduced with maximal activation potential at 0 mV. Administration of Ang II (100 nmol/L) enhanced the peak of I(Ca.L) during ischemia and shifted the maximal activation potential to -10 mV. The possible mechanism of these effects is discussed.


Asunto(s)
Animales , Angiotensina II , Farmacología , Canales de Calcio Tipo L , Células Cultivadas , Cobayas , Ventrículos Cardíacos , Biología Celular , Miocitos Cardíacos , Biología Celular , Técnicas de Placa-Clamp
2.
Acta Physiologica Sinica ; (6): 149-153, 2002.
Artículo en Chino | WPRIM | ID: wpr-279321

RESUMEN

The experiments were carried out on guinea pig isolated ventricular myocytes by using whole-cell patch clamp. The effects of angiotensin II (Ang II) on potassium ion channels of acute ischemic myocytes were observed. Whole-cell patch clamp recordings showed that physiological potassium current, including delayed rectifier potassium current and inward rectifier potassium current were inhibited under the condition of simulated ischemia, and then further inhibited by treatment with Ang II. ATP-sensitive potassium currents were increased under simulated ischemia and were further enhanced by Ang II treatment.


Asunto(s)
Animales , Femenino , Masculino , Angiotensina II , Farmacología , Células Cultivadas , Cobayas , Ventrículos Cardíacos , Biología Celular , Isquemia Miocárdica , Patología , Miocitos Cardíacos , Canales de Potasio , Fisiología
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