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Objective@#To evaluate the effects of different interventions on adolescents’ Internet addiction and to clarify the optimal interventions, so as to provide a reference for intervention for adolesents’ Internet addiction.@*Methods@#A randomized controlled trial of Internet addiction interventions in domestic and foreign databases such as Web of Science, PubMed, EMBASE, ProQuest, China Knowledge Network, Wanfang, and Weipu was conducted. The search time was built until November 29, 2019. The network Meta-analysis was performed using Stata 14.0. The standard mean difference(SMD) and 95%CI were used as the effect indicators to compare the effects of the interventions, and to sort the effects and identify the optimal measures.@*Results@#A total of 56 articles were included, with a total of 3 705 Internet addicts, including 11 interventions.The analysis showed that compared with the non-intervention group,the general group psychological intervention, group CBT, exercise intervention, family intervention, electroacupuncture intervention, other intervention and comprehensive intervention had statistically significant differences in reducing the effect of internet addiction(SMD=-1.17, -1.57, -1.07, -2.21, -2.56, -1.86, -1.54, -2.61, P<0.05); Compared with the general mental health education group, in addition to general group psychological intervention, interpersonal intervention and drug intervention(P>0.05), the other interventions have statistically significant differences in reducing the effects of Internet addiction(P<0.05); Internet addiction interventions are ranked according to the highest to lowest efficacy In turn, comprehensive intervention, family intervention, exercise intervention, electroacupuncture intervention, individual CBT, other intervention, interpersonal intervention, general group intervention,group CBT, general mental health education and drug intervention.@*Conclusion@#Comprehensive intervention shows the best effects for adolescent Internet addiction. In a single-measure intervention, family intervention is the best. In real life, appropriate interventions can be used according to the actual situation for addiction treatment.
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BACKGROUND: Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant. RESULTS: In this study we revealed that a new microRNA (miR), the miR-221, was highly expressed in the glioma cells, and suppression of miR-221 resulted in decreased cellular proliferation, migration, and invasion in glioma cells. Mechanistic experiments validated that miR-221 participates in regulating glioma cells proliferation and invasion via suppression of a direct target gene, the Semaphorin 3B (SEMA3B). The rescue experiment with miR-221 and SEMA3B both knockdown results in significant reversion of miR-221 induced phenotypes. CONCLUSION: Taken together, our findings highlight an unappreciated role for miR-221 and SEMA3B in glioma.