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OBJECTIVE: To develop a highly snsitive and specific LC-MS/MS method to explore the pharmacokinetic propeties of ginsenoside Rb1. METHODS: Ginsenoside Rb1 dissolved in normal saline was administered in a dose of 100 mg·kg-1 via gastric in fusion and 10 mg·kg-1 by intravenous injection in rats. Plasma was collected from fundus oculi venous plexus and ginsenoside Rb1 was analyzed by a validated LC-MS/MS method in plasma after intravenous and oral administration. The pharmacokinetic parameters were evaluated by software PKSolver V2.0. RESULTS: The main pharmacokinetic parameters of ginsenoside Rb1 after oral administration of 100 mg·kg-1 dosage were as follows: ρmax (2.01 ± 0.93) μg·mL-1, tmax (7.20 ± 5.49) h, t1/2 (25.91 ± 15.84) h, AUC0~96h (88.47 ± 58.99) μg·h·mL-1. The main pharmacokinetic parameters of ginsenoside Rb1 after intravenous administration of 10 mg ·kg-1 dosage were as follows: ρmax (194.81 ± 28.84) μg·mL-1, t1/2α (0.18 ± 0.05) h, t1/2β (14.66 ± 4.19) h, AUC0~96h (1671.16 ± 388.91) μg·h·mL-1. CONCLUSION: The ginsenoside Rb1 of orally administered was 0.62%, shows poor absolute bioavailability, and intravenous injection directly distribute into the blood vessels, can be the priority.
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OBJECTIVE: To review the pharmacological effects of ginsenoside Rb1 research progress. METHODS: According to domestic and foreign research reports of ginsenoside Rb1 in recent years, the pharmacological effects of Rb1 research progress. RESULTS: This article reviewed pharmacological effects and pharmacokinetic research of ginsenosides Rb1 from the central nervous system, cardiovascular system, immune system, and anti-tumor, anti-hepatic warm ischemia-reperfusion, lowering blood sugar and other aspects. CONCLUSION: Ginsenoside Rb1 is an important chemical material with a lot of pharmacological activities, studying its pharmacological effects can provide relevant information for further its development and utilization.