RESUMEN
In adults, acute myeloid leukaemias constitute 80% of all acute leukaemia cases; its incidence progressively increases with age To define the clinical and haematological parameters of adult acute myeloid leukaemia in Erbil City. A painstaking analysis of hospital records of 94 adult patients with acute myeloid leukaemia was undertaken. The cases were diagnosed and managed at Nanakaly hospital during the years 2006-2009. Diagnosis was based on peripheral blood and marrow findings. The myeloid origin was confirmed by cytochemistry, and morphological subtyping was done according to the French-American-British [FAB] criteria. Microsoft excel version 2007 was employed for carrying out statistical analysis. The studied group included 58 males and 36 females [M: F = 1.6:1]. Their ages ranged between 16 and 75 years with a mean age of 33.8 years. Pallor was the commonest presenting feature [70.2%] followed by bleeding [22.3%] then fever [7.5%]. The mean value of Hb was [7.6] g/dl, WBCs [34.5 x10[6]/ L], platelets [39.6 x10[9]/ L]; the percentage of blast cells in peripheral blood was 42.5% and in the bone marrow was 65.9%. AML-M[2] was the most frequent FAB subtype 24.4%. AML was commoner in males than in females [1.6:1]. AML-M[2] was the commonest FAB subtype. Pallor was the commonest presenting feature. Sudan black-B stain was a useful tool in the diagnosis of myeloid leukaemia
RESUMEN
Studying the relation of LDH level to presentation, stage and histological subtype of lymphoma and to evaluate its prognostic significance, Hospital records of 13 Hodgkin's and 37 non-Hodgkin's lymphoma patients were reviewed. Patients were followed up; their serum LDH levels were measured after completing therapy, A group of 25 apparently healthy persons matched for age and gender served as controls and their serum LDH levels were measured, Serum LDH activity was significantly higher in lymphoma patients compared to control group [P= 0.001]; although none of the Hodgkin's lymphoma patients had serum LDH level above the normal range. Serum LDH activity was not of value in relation to grade and histological subtype of lymphoma, and ESR; but significantly associated with stage of the disease. There was no significant difference in the mean enzyme level among patients who responded and those who not responded to chemotherapy. Serum LDH level was of no clinical or prognostic significance in Hodgkin's lymphoma. The stage of the disease rather than serum LDH value was the main prognostic marker in non-Hodgkin's lymphoma