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Chinese Journal of Virology ; (6): 44-50, 2013.
Artículo en Chino | WPRIM | ID: wpr-339976

RESUMEN

Vpr, an auxiliary protein of HIV-1(Human immunodeficiency virus type 1), exerts important functions to promote viral replication and AIDS progression. In this study, we performed a yeast two-hybrid screening assay using human cDNA library to further investigate the molecular mechanism of various functions of Vpr RelB, a key protein in NF-kappaB signaling pathway, was identified as a Vpr interaction protein by co-immunoprecipitation. Further investigations indicated that RelB not only promoted the Vpr-mediated activation of NF-kappaB reporter gene, but also enhanced the transactivation of HIV LTR. Moreover, the results showed that RelB promoted Vpr-induced cell cycle G2/M arrest. Collectively, these results indicated that RelB might interact with Vpr and regulate its transcriptional activation and cell cycle arrest.


Asunto(s)
Humanos , Puntos de Control del Ciclo Celular , División Celular , Fase G2 , Duplicado del Terminal Largo de VIH , Células HeLa , FN-kappa B , Genética , Factor de Transcripción ReIB , Fisiología , Activación Transcripcional , Productos del Gen vpr del Virus de la Inmunodeficiencia Humana , Fisiología
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