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1.
Journal of Central South University(Medical Sciences) ; (12): 650-654, 2006.
Artículo en Chino | WPRIM | ID: wpr-813628

RESUMEN

OBJECTIVE@#To determine the relationship between the nitroglycerin tolerance and the stimulation of radical oxygen species (ROS) production, and the therapeutical effect of 3,4,5,6-tetrahydroxyxanthone.@*METHODS@#Vasodilator responses to nitroglycerin were examined in the isolated thoracic aorta. The contents of ROS,and cGMP were determined in the cultured human umbilical vein endothelial cells.@*RESULTS@#3,4,5,6-tetrahydroxyxanthone could significantly reduce the inhibition of relaxation by nitroglycerin. 3,4,5,6-tetrahydroxyxanthone could significantly inhibit the ROS increase and increase the cGMP level.@*CONCLUSION@#Nitroglycerin tolerance is associated with the stimulation of ROS production,and the reversal of nitroglycerin tolerance with 3,4,5,6-tetrahydroxyxanthone is related to the reduction of ROS.


Asunto(s)
Animales , Humanos , Masculino , Ratas , Antioxidantes , Farmacología , Aorta Torácica , Biología Celular , Células Cultivadas , Tolerancia a Medicamentos , Endotelio Vascular , Biología Celular , Nitroglicerina , Farmacología , Estrés Oxidativo , Ratas Sprague-Dawley , Especies Reactivas de Oxígeno , Metabolismo , Venas Umbilicales , Biología Celular , Xantonas , Farmacología
2.
Journal of Central South University(Medical Sciences) ; (12): 659-662, 2006.
Artículo en Chino | WPRIM | ID: wpr-813626

RESUMEN

OBJECTIVE@#To investigate the effect of reinioside C (RC) on the expression of lectin-like oxidized low density lipoprotein receptor (LOX)-1 mRNA and LOX-1 protein induced by oxidized low density lipoprotein (ox-LDL) in cultured human umbilical vein endothelial cells (HUVEC).@*METHODS@#HUVECs were cultured with ox-LDL (50 mg/L) for 24 h in the absence or presence of RC (1, 3, and 10 micromol/L). The expressions of LOX-1 mRNA and LOX-1 protein were examined by RT-PCR and Western-blot.@*RESULTS@#Incubation with ox-LDL (50 mg/L) significantly raised the expression of LOX-1 mRNA and LOX-1 protein,which was concentration-dependent.@*CONCLUSION@#RC can inhibit the increased expression of LOX-1 mRNA and LOX-1 protein induced by ox-LDL in HUVECs.


Asunto(s)
Humanos , Células Cultivadas , Medicamentos Herbarios Chinos , Farmacología , Endotelio Vascular , Lipoproteínas LDL , Farmacología , Polygala , Química , ARN Mensajero , Genética , Receptores de LDL , Genética , Saponinas , Farmacología , Venas Umbilicales , Biología Celular , Metabolismo
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