RESUMEN
Bacteria are the major etiologic factor of periodontitis, which exhibits inflammation and destruction of periodontal tissue. Aim of the periodontal treatment is elimination or reduction of periodontopathogens by means of mechanical instrumentation and oral hygiene instruction. Subgingival recolonization of periodontal pathogens was slowly occurred in a few months after mechanical treatment although well plaque control was performed. Local antimicrobial agents were introduced for periodontal therapy as an adjunctive treatment. It has low side effects to oral and non-oral sites and shows higher drug concentration in gingival crevicular fluid than those by systemic route. This review article included general principles to be considered of local drug use, type of drug, effect of oral environment on drug stability, relationship between concentration and contact duration, effect of biofilm on drug concentration, and local drug use in an initial therapy and after active phase of treatment. It will be information for dentist to use the local drug as an adjunctive treatment of periodontitis. Key Words: Periodontitis, antimicrobial agents, antibiotics, local drug use
RESUMEN
Platelet rich plasma (PRP) has been used as an accelerator in bone healing in implant dentistry with conflicting results. Aim of this study was to compare bone regeneration rate histomorphometrically, between the use of PRP and e- PTFE membrane in artificial defects of the canine mandible at different periods of healing. Four standardized artificial defects were prepared at the lower border of mandibles of ten dogs. One defect was filled with PRP, one was covered with e-PTFE membrane (Goretex®), one was filled with PRP and covered with e- PTFE membrane, and one defect served as control. Collagen (Tissue vlies®) was added to each defect. Samples were taken from two animals at 2, 4, 6, 8 and 12 weeks. Representative bone specimens were fixed in 10 % buffered formalin prior to histological preparation of ground sections. Digital images of sections were analyzed histomorphometrically for newly formed bone. Results were analysed statistically. Results at different healing periods showed that addition of PRP did not improve healing of bone significantly (p=0.53). The use of e-PTFE membrane improved bone healing after two weeks significantly (p