Mean platelet volume and glycemic control in patients with type 2 diabetes

The mean platelet volume [MPV] is a marker of platelet activity. The increased platelet activity may play a role in the development of vascular complications of type 2 diabetes. The association between platelet activity and glycemic control in diabetics is uncertain. Therefore, We aim 10 assess MPV in patients with type 2 diabetes and to determine the correlation of MPV with the degree of glycemic control Platelet counts and MPV were measured in 60 Type 2 diabetic patients and 20 healthy subjects using an automated blood cell counter. The fasting plasma glucose levels, two-hour postprandial plasma glucose levels and HbAlc levels were also measured. Also, patients with type 2 diabetes were classified into two groups according to their HbAlc levels: group A with HAlc <7% and group B with HAlc >/= 7%. The MPV was significantly higher in diabetics compared to the healthy subjects [8.9 +/- 1.1 fl versus 7.2 +/- 0.9 fl [P< 0.001]]. MPV showed a strong positive correlation with fasting plasma glucose, two-hour postprandial plasma glucose and HbAlC levels [P<0.001 for each]. The MPV in groupB [9.2 +/- L4 ft] was significantly higher than that of group A[8.4 +/- 1.3 fl;P = 0. 003]. We concluded that mean platelet volume is significantly higher in type 2 diabetes and this is more apparent in those with poorer glycemic control. Therefore, glycemic control may decrease the platelet hyperactlvity and thus may prevent or delay possible diabetic vascular complications

Obstructive sleep apnea among patients with type 2 diabetes: prevalence and effect on glycemic control

Obstructive sleep apnea [OSA] is a highly prevalent comorbidity of type 2 diabetes. The aim of this work is to determine the risk of OSA in patients with type 2 diabetes and its effect on the glycemic control. This study was conducted at Assiut University Hospital Sleep Unit, 52 patients with type 2 diabetes were included, all patients underwent an overnight polysomnography [PSG] and glycosylated hemoglobin [HbAlc] measurement. A total of 62% [n 32] of patients with type 2 diabetes had OSA[apnea-hyponea index [AHI] >/= 5 events/hour]. 27% [n=14] of patients had mild OSA [5 /= 30]. There was a significant positive correlation of HhAlc levels with apnea hypopnea index, a widely accepted marker of the severity of OSA [P<0.001]. Also, we found that increasing OSA severity was correlated with increasing HbAlc levels [p<0.001]. The mean llbAlc values were 8.2% for those without OSA, 9.4% for mild OSA, 10.1% for moderate OSA and 10.6% for severe OSA. We concluded that the prevalence of OSA in this study was 62% and increasing severity of OSA is associated with poorer glycemic control. Therefore, identifying and treating OSA in patients with type 2 diabetes may improve their glycemic control