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Objective To observe the effect of Shenmai injection combined concurrent chemoradiotherapy on immune function in patients with locally advanced non-small cell lung cancer.Methods A total of 80 patients with locally advanced non-small cell lung cancer were randomly divided into treatment group and control group.In treatment group,40 patients received simultaneous three-dimensional conformal radiotherapy combined with TP(docetaxel+cisplatin)chemotherapy,while given Shenmai injection in the process of concurrent chemoradiotherapy.In control group,40 patients only received chemoradiotherapy.The changes of T cell subsets were observed between the two groups.Results It showed no significant differences in percentages of CD+3,CD+4,CD+16CD+56and CD+4/CD+8 ratio between two groups pre-treatment(all P＞0.05).There were no significant adverse reactions occurred after received Shenmai injection in treatment group.Conclusion It play an important role in improving immune function of patients with locally advanced non-small cell lung cancer who received Shenmai injection combined concurrent chemoradiotherapy.
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[Objective]To study the optimum techniques making Anxinkang drop pills. [ Methods ] Using parallel experimentation for the choice of Matrix and refrigerant,dropping distance and rate,the temperranture of refrigerant.Using orthogonal experimentation for the choice of proportion of extract and Matrix,proportion of extract,water and glycerin, the temperature of drug solution.with quality of outward appearance as the evalution quota to decide the best dropping condition.[ Results ]The optimum technique was that PEG6000∶PEG4000(3∶2) as matrix,Methyl-siliconoil:liquid-paraffin(3∶1) is refigerant.Internal and external diameter of burette are equal to 2.5mm and 3mm .Drug is dropping into the refrigerant of about15~20 drop per minute [ conclusion ] The oplimum techniques are feasible and accord with the quality standards of drop pills.
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AIM: To estabolish the method for quality control of Anxinkang Dripping Pills(Radix Sophorae Flavescentis,Radix Astragali,etc.) METHODS: Using TLC to identify the dripping pills,matrine and oxymatrine in dripping pills were determined by RP-HPLC.Using C_(18) column,the mobile phase was made from the acetone methanol-H_3PO_4(3∶7∶90),the detection wavelength was at 210 nm. RESULTS: The herbs could be(identified) by TLC.For matrine,the linear range was from 0.05-0.50 ?g,and the average recovery was 97.3%,and for oxymatrine,the linear range was from 0.1-1.0 ?g,and the average recovery was 97.6%. CONCLUSION: The method is simple,reliable,accurate and can be applied to the quality control of the Anxinkang Dri-(pping) Pills.