RESUMEN
Male Wistar rats were randomized into 3 groups:The rats of group I received sham burning to serve as the control and those of groups and Ⅲ were inflicted with 20% and 30% TBSA third degree phosphorus burns respectively.No treatment was given to group Ⅱ.Group Ⅲwas further divided into 2:The rats of subgroup Ⅰ were debrided immediately and those of subgroup Ⅱ in the 6th hour postburn.The findings were as follows;(l)The tissue content of phosphorus was more significantly decreased in subgroup Ⅰ than in subgroup Ⅱ-(2)Twenty-eight rats of subgroup Ⅰ all survived while 9 of the 44 rats of subgroup Ⅱ died with a mortality rate of 20.5%.The mortality rate of group Ⅱ was 37.5%(3/8).(3)The recovery of serum electrolytes and other biochemical parameters occurred earlier in subgroup I.Our findings suggest that debridement as early as possible after phosphorus burns contributes significantly to the decrease of the victims mortality.
RESUMEN
usually in the 24th to 72nd h postburn.There was edema associated with mild necrosis of the duodenal mucosa immediately after burns.Severe necrosis occurred in the 2nd h postburn.The manifestations reached the peak in the 24th h and were alleviated in the 72nd h postburn.As a rule,the damages on the duodenal mucosa occurred early and persisted for a long period with high incidence and severe wounding conditions.The damages of gastroduodenal mucosa were more severe in the phosphorus burn group than in the napalm burn proup mainly because of the more intense heat stress after phosphorus burns and the tosicity of the element phosphorus and phosphorus free redicals.
RESUMEN
In order to study the mechanism of the barrier functional impairment-of gastric mucosa after burus, phosphorus or napalm 30% TBSA Ⅲ? burns was inflicted to rats and the osmolarity of hydrogen and chlorine ions of their gastric lavage fluid was determined. It was found the concentrations of the 2 ions in the lavage fluid decreased immediately after burn injury, reached the lowest point in the 5th hour postburn, and did not return to its preburn level even in the 72nd hour postburn.It is considered by the authors that the lowering of hydrogen and chlorine ions in the gastric lavage fluid after burns results from the reversed diffusion of the ions into the gastric mucosa since the stress reaction of the organism towards severe burns can impair the barrier function of the gastric musosa and the increase of hydrogen ions in gastric mucosa can aggravate the function impairment. In addition, phosphorus is a cytoplasm toxic. It can be rapidly absorbed through the cutaneous tissue of the burned area and carried to the gastric mucosa to intensify the mucosal lesion.