pharmaceutical study on topically applied tenoxicam gel

Tenoxicam transparent oil-water [TOW] gels were prepared using different oils; namely, isopropyl myristate, liquid paraffin, and myritol 318. The emulsifying agents used were Eumulgin B3, Cetiol HE, Brij 96, and Tween 80. The prepared gels were examined visually, microscopically and were photomicrographed. Conductivity, pH as well as rheological properties were determined. In vitro release studies, accelerated stability testing, and determination of anti-inflammatory activity were also performed. The results revealed that tenoxicam TOW gel prepared with liquid paraffin, Eumulgin B3, Cetiol HE combination and water [formula IV] was the most stable formula. It also affords reasonable pH, conductivity, rheological properties and in vitro drug release. The selected formula showed appreciable anti-inflammatory activity [determined by the Carrageenan induced rat paw edema] compared with a commercial piroxicam gel

Preparation and evaluation of controlled release frusemide tablets using gel matrix systems

Controlled release frusemide matrix tablets were prepared using different polymers; namely, xanthan gum [XG], hydroxypropylmethyl cellulose 4000 [HPMC 4000] and sodium carboxymethylcellulose [NaCMC] at different concentrations. The prepared tablets were subjected to in vitro release studies as well as medium penetration and wet/dry weight determinations to elucidate the overall mechanism of drug release from the matrix tablets. The release rate studies showed that the most drug sustainment was obtained from tablets prepared with 10% w/w XG when compared with those prepared with 20% w/w HPMC 4000 or 60% w/w NaCMC. The results of medium penetration and wet/dry weight determinations indicated that the highest liquid uptake and medium infiltration and erosion were obtained with NaCMC tablets. The data of the release rate studied were subjected to kinetic treatment in an attempt to obtain linear correlations