1.
Artículo
en Inglés
| IMSEAR
| ID: sea-41990
RESUMEN
The result reported here represents the first human genomic screen for MSI in Epstein-Barr-Virus associated NPC. The analysis revealed the incidence of MSI only 1 of 23 cases (4%) which indicates that MSI is less common in NPC development.
Asunto(s)
Cartilla de ADN , ADN de Neoplasias/genética , ADN Viral/genética , Infecciones por Herpesviridae/genética , Herpesvirus Humano 4/genética , Humanos , Repeticiones de Microsatélite , Neoplasias Nasofaríngeas/genética , Reacción en Cadena de la Polimerasa , Infecciones Tumorales por Virus/genética
2.
Artículo
en Inglés
| IMSEAR
| ID: sea-40605
RESUMEN
In order to demonstrate and define possible tumor suppressor gene loci on chromosome 11 associated with NPC, we used 7 STR to test for LOH on 25 NPC samples. LOH was detected in 46 per cent of cases. Most LOH loci were clustered on the long arm. Further study demonstrated 22 per cent and 45.5 per cent of cases with LOH on 11q13 and 11q23 respectively.