1.
Artículo
en Inglés
| IMSEAR
| ID: sea-63780
RESUMEN
BACKGROUND: Gastric carcinoma is frequently refractory to chemotherapy. The multidrug resistance 1 gene (MDR1) encodes for a protein (p-glycoprotein) that functions as a drug efflux pump and thus contributes to resistance to chemotherapeutic agents. METHODS: We studied gastric tissues from 28 patients with gastric cancer for MDR1 expression, using immunohistochemistry. RESULTS: Sixteen (57%) of 28 cases showed MDR1 expression. Sections of normal mucosa away from the tumor showed perinuclear staining for MDR1 in surface epithelial cells, whereas tumor cells showed diffuse cytoplasmic positivity. CONCLUSIONS: Over one half of gastric carcinoma specimens at our center show MDR1 gene expression.
Asunto(s)
Anciano , Femenino , Expresión Génica , Genes MDR/fisiología , Humanos , Inmunohistoquímica , India , Masculino , Persona de Mediana Edad , Estudios Seroepidemiológicos , Neoplasias Gástricas/genética
2.
J Indian Med Assoc
;
1985 Sep; 83(9): 314-5
Artículo
en Inglés
| IMSEAR
| ID: sea-100882
3.
Indian J Pathol Microbiol
;
1984 Jul; 27(3): 223-8
Artículo
en Inglés
| IMSEAR
| ID: sea-73439