1.
Indian J Exp Biol
;
1990 May; 28(5): 486-7
Artículo
en Inglés
| IMSEAR
| ID: sea-57642
RESUMEN
Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependant manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls. There was no alteration in barbital sodium sleeping time. It is possible that, piperine inhibits liver microsomal enzyme system and thereby potentiates the pentobarbitone sleeping time.
Asunto(s)
Alcaloides , Animales , Benzodioxoles , Sinergismo Farmacológico , Hipnóticos y Sedantes , Masculino , Microsomas Hepáticos/efectos de los fármacos , Pentobarbital/administración & dosificación , Piperidinas/administración & dosificación , Alcamidas Poliinsaturadas , Ratas , Sueño/efectos de los fármacos
2.
Hindustan Antibiot Bull
;
1984 Aug-Nov; 26(3-4): 138-9
Artículo
en Inglés
| IMSEAR
| ID: sea-2274
3.
Hindustan Antibiot Bull
;
1981 ; 23(): 6-11
Artículo
en Inglés
| IMSEAR
| ID: sea-2631