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2.
Indian J Physiol Pharmacol ; 1993 Jul; 37(3): 244-6
Artículo en Inglés | IMSEAR | ID: sea-106978

RESUMEN

Male albino rats weighing between 150-225 gm fasted over night but freed having water ad libitum were used to assess the diuretic efficacy of intramuscular aminophylline and frusemide separately and concurrently after intraperitoneal 10 ml of distilled water loading. The normal rate of diuretic weight loss was less augmented by aminophylline and more augmented by frusemide. The diuretic response was more by the concurrent intramuscular administration of aminophylline and frusemide in comparison with that due to either drug alone. However, the observed diuretic response of the two drugs administered concurrently was lesser (infraadditive) than the sum of the individual diuretic response (additive).


Asunto(s)
Aminofilina/farmacología , Animales , Peso Corporal/efectos de los fármacos , Diuréticos/farmacología , Interacciones Farmacológicas , Furosemida/farmacología , Masculino , Ratas
6.
Indian J Physiol Pharmacol ; 1984 Jul-Sep; 28(3): 250-2
Artículo en Inglés | IMSEAR | ID: sea-107645
7.
Indian J Physiol Pharmacol ; 1984 Apr-Jun; 28(2): 141-4
Artículo en Inglés | IMSEAR | ID: sea-106966

RESUMEN

Parachloromercury benzoate (PCMB), a sulphydryl inactivator, caused a progressively increasing inhibition of tissue responses to acetylcholine, adrenaline, noradrenaline and serotonin in vitro. This inhibition was progressively and completely reversed by penicillamine, a sulphydryl activator. It is inferred that intact sulphydryl groups are essential for constancy of responses of excitable tissues to the neurotransmitters.


Asunto(s)
Acetilcolina/farmacología , Animales , Cloromercuribenzoatos/farmacología , Epinefrina/farmacología , Contracción Muscular/efectos de los fármacos , Norepinefrina/farmacología , Penicilamina/farmacología , Conejos , Ratas , Serotonina/farmacología , Compuestos de Sulfhidrilo/farmacología , Ácido p-Cloromercuribenzoico
15.
Indian J Physiol Pharmacol ; 1981 Jul-Sep; 25(3): 269-73
Artículo en Inglés | IMSEAR | ID: sea-106206

RESUMEN

Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.


Asunto(s)
Aminas/farmacología , Animales , Temperatura Corporal/efectos de los fármacos , Encéfalo/efectos de los fármacos , Masculino , Bases de Mannich/farmacología , Pentobarbital/farmacología , Equilibrio Postural/efectos de los fármacos , Conejos , Ratas , Receptores de Droga/metabolismo , Umbral Sensorial/efectos de los fármacos , Sueño/efectos de los fármacos , Factores de Tiempo
16.
Indian J Physiol Pharmacol ; 1981 Apr-Jun; 25(2): 191-2
Artículo en Inglés | IMSEAR | ID: sea-106883
17.
Indian J Physiol Pharmacol ; 1981 Jan-Mar; 25(1): 91-2
Artículo en Inglés | IMSEAR | ID: sea-106886
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