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Rev. Soc. Bras. Med. Trop ; 38(supl.2): 101-104, 2005. graf
Artículo en Español | LILACS | ID: lil-444165

RESUMEN

The mechanisms of congenital transmission of Chagas disease remain largely unknown. To better understand the role of maternal immunology during pregnancy in congenital Chagas transmission, we studied the cytokine production and the parasitic load in three groups of mothers: infected mothers who transmitted the disease to their babies (M+B+-), infected mothers who did not transmit the disease to their babies (M+B-) and not infected mothers as a control group (M-B-). M+B+ mothers produced less IFNgamma and more IL-10 than the M+B- mothers, and they are not able to produce IL-2. M+B+ mothers showed a higher parasitic load. These results, indicated that the congenital Chagas transmission is associated with an immunological imbalance and a high parasitic load in the M+B+ mothers.


Asunto(s)
Animales , Femenino , Humanos , Embarazo , Citocinas/biosíntesis , Complicaciones Infecciosas del Embarazo/inmunología , Enfermedad de Chagas/inmunología , Enfermedad de Chagas/transmisión , Transmisión Vertical de Enfermedad Infecciosa , Trypanosoma cruzi/fisiología , Citocinas/inmunología , Enfermedad de Chagas/parasitología , Inmunidad Celular , Interferón gamma/biosíntesis , Interferones/biosíntesis , Portador Sano/inmunología
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