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1.
Mem. Inst. Oswaldo Cruz ; 101(2): 119-127, Mar. 2006. graf
Artículo en Inglés | LILACS | ID: lil-430886

RESUMEN

The prevalence of hepatitis A virus (HAV) infection is high in developing countries, in which low standards of sanitation promote the transmission of the virus. In Latin America, which is considered an area of high HAV endemicity, most HAV-positive individuals are infected in early childhood. However, recent studies have shown that prevalence rates are decreasing. Herein, we review the data on HAV prevalence and outbreaks available in scientific databases. We also use official government data in order to evaluate mortality rates in Brazil over the last two decades. Studies conducted in the northernmost regions of Brazil have indicated that, although improved hygiene has led to a reduction in childhood exposure to HAV, the greatest exposure still occurs early in life. In the Southeastern region, the persistence of circulating HAV has generated outbreaks among individuals of low socioeconomic status, despite adequate sanitation. Nationwide, hepatitis A mortality rates declined progressively from 1980 to 2002. During that period, mortality rates in the Northern region consistently exceeded the mean national rate and those for other regions. Excluding the North, the rates in all regions were comparable. Nevertheless, the trend toward decline observed in the South was paralleled by a similar trend in the North.


Asunto(s)
Humanos , Recién Nacido , Lactante , Preescolar , Niño , Adolescente , Adulto , Persona de Mediana Edad , Brotes de Enfermedades , Enfermedades Endémicas , Hepatitis A/mortalidad , Brasil/epidemiología , Hepatitis A/epidemiología , Hepatitis A/prevención & control , Incidencia , Prevalencia , Factores Socioeconómicos
2.
Mem. Inst. Oswaldo Cruz ; 100(2): 117-122, Apr. 2005. tab, graf
Artículo en Inglés | LILACS | ID: lil-410848

RESUMEN

Serological evidence of hepatitis E virus infection (HEV) has been observed in both humans and different animal species living in non-endemic areas, suggesting that animals could be important reservoir for virus transmission to man. Antibodies to HEV have been detected in some Brazilian population groups. Nevertheless, sporadic cases of acute HEV infection have never been reported. We collected 271 serum samples from several domestic animals and also from pig handlers from Southeast of Brazil in order to investigate the seroprevalence of HEV infection. Anti-HEV IgG was detected in cows (1.42 percent), dogs (6.97 percent), chickens (20 percent), swines (24.3 percent), and rodents (50 percent), as well as in pig handlers (6.3 percent). The recognition of swine HEV infections in pigs in many countries of the world led us to investigate a larger sample of pigs (n = 357) from the same Brazilian region with ages ranging from 1 to > 25 weeks. IgG anti-HEV was detected in 100 percent of 7-day old pigs. Following a gradual decline between weeks 2 and 8 (probably due to loss of maternal IgG), the prevalence then steady increased until it reached 97.3 percent of animals older than 25 weeks. Besides the detection of anti-HEV antibodies in different animal species, the results showed that swine HEV infection seems to be almost universal within this Brazilian pig population. This is the first report that shows evidences of HEV circulation in Brazilian animal species and pig handlers.


Asunto(s)
Animales , Bovinos , Perros , Humanos , Masculino , Reservorios de Enfermedades/veterinaria , Anticuerpos Antihepatitis/sangre , Virus de la Hepatitis E/inmunología , Hepatitis E/veterinaria , Inmunoglobulina G/sangre , Brasil/epidemiología , Cebidae , Cabras , Hepatitis E/diagnóstico , Hepatitis E/epidemiología , Prevalencia , Roedores , Estudios Seroepidemiológicos , Ovinos , Porcinos
3.
Mem. Inst. Oswaldo Cruz ; 93(1): 1-5, Jan.-Feb. 1998. tab, graf
Artículo en Inglés | LILACS | ID: lil-201984

RESUMEN

The age-specific prevalence of antibodies to hepatitis A virus (anti-HAV) was determined in two different population groups with low socio-economic status from Rio de Janeiro city, Brazil, whose serum were collected 17 years apart (Population 1, 1978; Population 2, 1995). In Population 2, analysis of the anti-HAV prevalence was also carried out with respect to environmental factors. Population 1 was composed of 520 stored sera collected from the umbilical cord of term neonates and children aged 1 month to 6 years. In population 2, 720 serum samples were collected from children and adolescents with ages ranging from 1 to 23 years. The overall prevalence rate of anti-HAV in Population 1 and 2 was 65.6 per cent and 32.1 per cent, respectively. In Population 1, the anti-HAV prevalence reached 88 per cent at the age of 3, while in Population 2, it increased from 4.5 per cent in children under the age of 3 to 66 per cent in the group of adolescents over the age of 14. The low exposure to HAV infection in younger children from Population 2 could be a result of improved environmental hygiene and sanitation, as demonstrated by the presence of piped water, waste and sewage disposal systems in most houses from this population group. These findings indicate a possible change in the prevalence of hepatitis A in Rio de Janeiro.


Asunto(s)
Humanos , Niño , Adolescente , Recién Nacido , Distribución por Edad , Anticuerpos Antihepatitis , Hepatitis A/inmunología , Brasil , Estudios Transversales , Virus de la Hepatitis A Humana/inmunología
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