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Braz. j. infect. dis ; 22(5): 377-386, Sept.-Oct. 2018. tab, graf
Artículo en Inglés | LILACS | ID: biblio-974239

RESUMEN

ABSTRACT Background: Influenza continues to drive seasonal morbidity, particularly in settings with low vaccine coverage. Objectives: To describe the influenza cases and viral circulation among hospitalized patients. Methods: A prospective study based on active surveillance of inpatients with influenza-like illness from a tertiary hospital in Bucharest, Romania, in the season 2016/17. Results: A total of 446 patients were tested, with a balanced gender distribution. Overall, 192 (43%) patients tested positive for influenza, with the highest positivity rate in the age groups 3-13 years and >65 years. Peak activity occurred between weeks 1 and 16/2017, with biphasic distribution: A viruses were replaced by B viruses from week 9/2017; B viruses predominated (66.1%). Among the 133 (69.3%) subtyped samples, all influenza A were subtype H3 (n = 57) and all influenza B were B/Victoria (n = 76). Patients who tested positive for influenza presented fewer comorbidities (p = 0.012), except for the elderly, in whom influenza was more common in patients with comorbidities (p = 0.050). Disease evolution was generally favorable under antiviral treatment. The length of hospital stay was slightly longer in patients with influenza-like illness who tested patients negative for influenza (p = 0.031). Conclusions: Distinctive co-circulation of A/H3 and B/Victoria in Bucharest, Romania in the 2016/17 influenza season was found. While the A/H3 subtype was predominant throughout Europe that season, B/Victoria appears to have circulated specifically in Romania and the Eastern European region, predominantly affecting preschoolers and school children.


Asunto(s)
Humanos , Masculino , Femenino , Lactante , Preescolar , Niño , Adolescente , Adulto , Persona de Mediana Edad , Anciano , Adulto Joven , Estaciones del Año , Síndrome Respiratorio Agudo Grave/epidemiología , Gripe Humana/epidemiología , Monitoreo Epidemiológico , Virus de la Influenza A/aislamiento & purificación , Virus de la Influenza B/aislamiento & purificación , Rumanía/epidemiología , Factores de Tiempo , Comorbilidad , Vigilancia de la Población , Vacunación Masiva/estadística & datos numéricos , Estudios Prospectivos , Distribución por Edad , Síndrome Respiratorio Agudo Grave/patología , Síndrome Respiratorio Agudo Grave/virología , Gripe Humana/patología , Gripe Humana/virología , Centros de Atención Terciaria/estadística & datos numéricos
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