RESUMEN
Oncogene activation and inactivation of tumor suppressor genes is an important molecular mechanism of tumor formation. HER-2 oncogene is associated with breast cancer invasion and metastasis and prognosis, HER-2 overexpressing breast cancer progresses rapidly and has poor prognosis. In recent years, the emergence of targeted therapeutic monoclonal antibody drug Herceptin which built its structure for the HER-2 has significantly inproved HER-2-positive advanced breast cancer.
RESUMEN
OBJECTIVE@#To assess the value of fiberoptic ductoscopy (FDS) in the diagnosis of nipple discharge.@*METHODS@#Clinical records of 1,025 patients with nipple discharge undergoing FDS from February 2006 to March 2008 were reviewed.@*RESULTS@#There were obviously differences in the FDS diagnosis of various nipple discharge traits. The diagnosis by FDS was pathologically confirmed in 93.7%of patients with nipple discharge (404/431).@*CONCLUSION@#FDS can effectively improve the diagnosis of nipple discharge,and has great clinical significance.
Asunto(s)
Adolescente , Adulto , Anciano , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven , Enfermedades de la Mama , Diagnóstico , Patología , Neoplasias de la Mama , Diagnóstico , Metabolismo , Patología , Endoscopía , Métodos , Tecnología de Fibra Óptica , Métodos , Pezones , Metabolismo , Papiloma Intraductal , Diagnóstico , Metabolismo , Patología , Estudios Retrospectivos , Sensibilidad y EspecificidadRESUMEN
Objective To investigate the antioxidation of bioactive proteins from the meat of Meretrix meretrix.Methods Three protein peaks(P1,P2 and P3) were isolated from the meat of Meretrix meretrix by homogenating,step precipitating with ammonium sulfate,chromatography with Sephadex G-150.CAT activity and SOD activity of these proteins were determined.Inhibition of the proteins to lipid peroxidation was determined.Results CAT activity of P2 was the highest,its specific activity was 77.0 U?mg-1.SOD activity of P3 was the highest,its specific activity was 68.8 U?mg-1.Inhibition of P3to lipid peroxidation was the most obvious,its inhibitive rate was 50% when the protein content was 20 ?g.SDS-PAGE results showed that the main composition of P1 was the protein,the Mr of which was 18.0 kD.The protein band of P2 corresponded with the protein band of contrast CAT,its Mr was 28.0 kD.The protein band of P3 corresponded with the protein band of contrast SOD,its relative Mr was 16.0 kD.Conclusion The bioactive proteins were isolated from the meat of Meretrix meretrix,and the bioactive proteins had antioxidation.