RESUMEN
There is a growing body of evidence that diabetes mellitus leads to a specific cardiomyopathy diabetic cardiomyopathy (DCM), which is apart from vascular disease. Lethal cardiac arrhythmia is frequently found in DCM patients, which is associated with prolongation of the QT interval in electrocardiogram (ECG), causing increased mortality in the patients with diabetes mcllitus. Thc change of ion channel is the basis for the prolonged cardiac action potential duration, mainly involving the change of calcium ions, potassium channels and sodium channels. In this paper we reviewed the recent progress in the changes of the ion channel in DCM patients.
RESUMEN
Gap junctions play a critical role in electrical synchronization and exchange of small molecules between neighboring cells; connexins are a family of structurally related transmembrane proteins that assemble to form vertebrate gap junctions. Hyperglycemia changes the structure gap junction proteins and their expression, resulting in obstruction of neural regeneration, vascular function and wound healing, and also promoting vascular atherosclerosis. These pathogenic factors would cause diabetic foot ulcers. This article reviews the involvement of connexins in pathogenesis of diabetic foot.