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1.
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 14-16, 2002.
Artículo en Inglés | WPRIM | ID: wpr-329144

RESUMEN

The pharmacokinetics and relative bioavailability were studied in 18 healthy volunteers. A single oral dose of 150 mg irbesartan capsule (test) or tablet (reference) was given to each volunteer according to a randomized 2-way crossover study. The concentrations in plasma were determined by HPLC-UV method. The main parameters of irbesartan capsules were: Cmax: 1.502 +/- 0.295 micrograms/ml, tmax: 1.44 +/- 0.34 h, t 1/2: 20.21 +/- 14.71 h, AUC0-t: 11.087 +/- 3.443 micrograms/ml-1.h. The relative bioavailability of capsule to tablet was (101.4 +/- 28.9)%. The results of statistical analysis showed that two formulations were bioequivalent.


Asunto(s)
Adulto , Humanos , Masculino , Antagonistas de Receptores de Angiotensina , Disponibilidad Biológica , Compuestos de Bifenilo , Sangre , Farmacocinética , Cápsulas , Estudios Cruzados , Comprimidos , Tetrazoles , Sangre , Farmacocinética
2.
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 14-6, 2002.
Artículo en Inglés | WPRIM | ID: wpr-634051

RESUMEN

The pharmacokinetics and relative bioavailability were studied in 18 healthy volunteers. A single oral dose of 150 mg irbesartan capsule (test) or tablet (reference) was given to each volunteer according to a randomized 2-way crossover study. The concentrations in plasma were determined by HPLC-UV method. The main parameters of irbesartan capsules were: Cmax: 1.502 +/- 0.295 micrograms/ml, tmax: 1.44 +/- 0.34 h, t 1/2: 20.21 +/- 14.71 h, AUC0-t: 11.087 +/- 3.443 micrograms/ml-1.h. The relative bioavailability of capsule to tablet was (101.4 +/- 28.9)%. The results of statistical analysis showed that two formulations were bioequivalent.


Asunto(s)
Disponibilidad Biológica , Compuestos de Bifenilo/sangre , Compuestos de Bifenilo/farmacocinética , Cápsulas , Estudios Cruzados , Receptores de Angiotensina/antagonistas & inhibidores , Comprimidos , Tetrazoles/sangre , Tetrazoles/farmacocinética
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