Inhibitory effect of melatonin on morphine withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice / 药学学报

<p><b>AIM</b>To observe the effect of melatonin (MT) on morphine withdrawal syndromes and determine the content of NO in plasma and brain tissue in morphine dependent mice.</p><p><b>METHODS</b>A physical dependent model in mice was established by subcutaneous injection of morphine. MT (15 mg.kg-1, qd x 3) was given by intragastric infusion (ig) for three days. Withdrawal syndromes were induced by intraperitoneal injection of naloxon (5 mg.kg-1). The intensity of withdrawal syndromes was evaluated according to the jumping latency, the jumping times and the body weight loss. The content of NO was detected with Griess method.</p><p><b>RESULTS</b>The jumping latency of morphine withdrawal reaction was prolonged and the jumping times were reduced obviously by ig MT. The increased NO content in plasma and brain tissue in morphine dependent mice was reduced by ig MT.</p><p><b>CONCLUSION</b>The physical withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice are inhibited by MT.</p>

Pathogenic Role of Glutamic Acid in Tourette's Syndrome / 实用儿科临床杂志

Objective To investigate the effect of glutamic acid (monosodium glutamate,MSG) on Tourette's syndrome (TS). Methods These rats were divided into 2 groups: one group with acute intracerebroventricularly injection (ICV) of MSG or artificial cerebrospinal fluid (CSF), and another group with chronic administration of MSG in a dose of 40 mg/kg in drinking water everyday. Observers who were blind to the two- part subjects assessed the scores of TS- like stereotyped locomotion. Results 1. These groups of 100 ?g or 200 ?g glutamic acid may induce significant TS - like stereotyped locomotion ( P