Effect of thymosin combined with antibiotics on acute exacerbation of chronic obstructive pulmonary disease in elderly patients and its influence to cellular immune function / 中国基层医药

Objective To investigate the clinical therapeutic effect of thymosin combined with antibiotics on acute exacerbation of chronic obstructive pulmonary disease in eldly patients ,and its influence on cellular immune function.Methods 60 elderly patients with acute exacerbation of chronic obstructive pulmonary disease were select-ed,by using the method of random number table,they were divided into the treatment group (n =30)and control group (n =30).The control group was given antibiotics and conventional treatment,the treatment group was given thymosin on the basis of treatment of the control group.The clinical curative effect and the influence of the cellular immune function were compared in the two groups.Results The after treatment 1s forced expiratory volume (FEV1 ),FEV1 /FVC(%)and FEV1 /expected value (%)of the treatment group were (1.59 ±0.15)L,(58.83 ± 13.14),(76.13 ±3.21),and those of the control group were (1.31 ±0.11)L,(54.62 ±12.41),(68.74 ±3.01), the differences were statistically significant (t =7.261,6.923,8.793,all P 0.05).Conclusion The clinical effect of thymosin combined with antibiotic therapy in the treatment of acute exacerbation of chronic obstructive pulmonary disease in elderly patients is remarkable,safe and reliable,and can improve the cellular immune function in patients,it is worthy of further clinical application.

Analysis of efficacy evaluation scales for anxiety treated with acupuncture-moxibustion / 中国针灸

Scales are important tools to measure and evaluate the severity degree and treatment effect of anxiety, but objective index with high quality is insufficient. Clinical researches of anxiety treated with acupuncture and moxibustion from the domestic and the oversea in recent 10 years are retrieved. The applications of all kinds of scales for anxiety treated with acupuncture and moxibustion in clinical research are analyzed, and problems needed to be paid attention to about scales are further explored. The establishment of effect evaluation system combining clinical symptoms with the quality of life is raised, so as to provide reference to further research.

Clinicai investigation on esomeprazoie treatment of sixty-nine asthmatic patients with gastroesophageal reflux symptoms / 中华消化杂志

Objective To study the efficacy of esomeprazole in treatment of asthmatic patients with gastroesophageal reflux (GER) symptoms. Methods Sixty-nine asthmatic patients with GER symptoms were received esomeprazole 40 mg daily and mosapride 5 mg three times daily for 8 weeks. After that, esomeprazole 20 mg and mosapride 5 mg daily were prescribed to the patients for sustained therapy. The effect of asthma control was evaluated according to criteria for asthma control level made by Chinese Society of Respiratory Disease Asthma Group. All patients were followed up for 2 years.Results It was revealed that complete asthma control was achieved in 39 patients, well control in 25 patients and the total effective rate was 93 %. Asthma-control medication was stopped in 42 patients,dose reduced to 1/2 in 18 patients and continuous therapy in 9 patients. During 2 years follow-up, 58 patients were benefited from the treatment with complete asthma control and seldom attack of asthma was seen in 11 patients with reduced frequency and severity. Conclusion The symptoms of asthmatic patients with GER symptoms can be improved by esomeprazole, so that their quality of life areimproved.

Attenuation Effect of Tianzhicao Capsules on Doxorubicin Induced Toxicity / 中国药房

OBJECTIVE: To search the attenuation action of Tianzhicao capsules on doxorubicin induced toxicity.METHODS: Hepatoma H22 tumor-bearing mice were administrated with Tianzhicao capsules and doxorubicin orally.Then the growth of mice,changes in electrocardiogram (ECG),myocardial enzymes and myocardial morphological changes were determined after administration.RESULTS:Tianzhicao capsules were not in synchronism with the action potential depolarization in ventricular muscle and cardiac injury induced by doxorubicin.Tianzhicao capsule also inhibited the increase of serum LHD and doxorubicin-induced cardiac injury.CONCLUSION: Tianzhicao capsules show attenuation effect on doxorubicin-induced toxicity.