Prognostic and clinical value of circPRKCI expression in diverse human cancers / 中华医学杂志(英文版)

BACKGROUND@#Highly expressed in various human cancers, circular RNA Protein Kinase C Iota (circPRKCI) has been reported to play an important role in cancer development and progression. Herein, we sought to reveal the prognostic and clinical value of circPRKCI expression in diverse human cancers.@*METHODS@#We searched the Pubmed, Web of Science, and the Cochrane Library databases from inception until May 16, 2021. The relationship between circPRKCI expression and cancer patients' survival, including overall survival (OS) and disease-free survival (DFS), was assessed by pooled hazard ratios (HR) with corresponding 95% confidence interval (CI). The correlation between circPRKCI expression and clinical outcomes was evaluated using odds ratios (OR) with corresponding 95% CI. The data were analyzed by STATA software (version 12.0) or Review Manager (RevMan 5.3).@*RESULTS@#A total of 15 studies with 1109 patients were incorporated into our meta-analysis. The results demonstrated that high circPRKCI expression was significantly related to poor OS (HR = 1.96, 95% CI: 1.61, 2.39, P <0.001) when compared with low circPRKCI expression in diverse human cancers. However, elevated circPRKCI expression was not associated with DFS (HR = 1.34, 95% CI: 0.93, 1.95, P = 0.121). Furthermore, the patient with a higher circPRKCI expression was prone to have a larger tumor size, advanced clinical stage, and lymph node metastasis, but it was not significantly correlated with age, gender, and distant metastasis.@*CONCLUSION@#Elevated circPRKCI expression was correlated with worse OS and unfavorable clinical features, suggesting a novel prognostic and predictive role of circPRKCI in diverse human cancers.

The Current Situation and Countermeasures of Ethics Education for Clinical Medical Postgraduates / 中国医学伦理学

In recent years, clinical research has developed rapidly in China and gradually converged with international standards. The importance of ethics education in clinical research for clinical medical postgraduates has become increasingly prominent. From the purpose of promoting the ethics education of clinical medical postgraduates, this paper expounded the significance of carrying out the ethics education of clinical research for clinical medical postgraduates, analyzed the current situation and problems of the ethics education of clinical research for domestic postgraduates, and put forward countermeasures and suggestions for strengthening the ethics education of clinical medical postgraduates. Specifically, this included increasing the degree of attention and rationally allocating teaching resources; paying attention to the transformation of theory into practice, and increasing the relevant curriculum; defining the training objectives, and conducting the staged cross-cultivation; adopting various teaching methods, and improving the training effect; utilizing clinical research practice to develop the ethics ability of clinical research.

Preliminary establishment and evaluation of a model for early diagnosis of acute aortic dissection / 中国综合临床

Objective:An early diagnosis model of acute aortic dissection (AAD) was established based on chest pain center database.Methods:The clinical data of patients who attended Chest Pain Center of Department of Emergency in Affiliated Hospital of Jining Medical University of Shandong Province from January 2020 to December 2020 were retrospectively collected. Patients were divided into AAD and non-AAD groups according to whether or not AAD was diagnosed. The clinical related indicators of the two groups were compared. The research indicators with statistical differences between the two groups were included in multivariate Logistic regression analysis, and the early diagnosis of AAD nomogram model was established. The receiver operating characteristic (ROC) curve of the model was used to evaluate the prediction accuracy, and the Homser-Lemeshow statistics were used to test the goodness of fit for the model. A total of 630 patients with chest pain who visited the hospital from January 2021 to March 2021 were also collected for external validation of the model. The t-test of independent samples was used to compare the measurement data of normal distribution, nonparametric test was used to compare the measurement data of skewness distribution, and χ 2 test was used to compare the counting data between groups. Results:A total of 2 738 patients were included, of which 4.09% (112/2 738) were AAD patients. Univariate analysis showed that in AAD group, male morbidity (74.11%(83/112)), hypertension history (70.54%(79/112)), aortic disease history (10.71%(12/112)), family history of aortic disease (4.46%(5/112)), sudden onset of symptoms (76.79%(86/112)), percentage of patients with laceration pain (38.39%(43/112)), patients with back pain (66.07%(74/112)), patients with abdominal pain (16.96%(19/112)), systolic blood pressure ((159.44±30.94) mmHg), bilateral blood pressure/pulse asymmetry (23.21% (26/112)), incidence of complicated neurological signs (7.14%(8/112)) and D-dimer (3.57(2.10, 6.62) mg/L) were significantly higher than those in non-AAD group (59.56%(1 564/2 626), 46.23%(1 214/2 626), 0.23%(6/2 626), 0.08%(2/2 626), 35.99%(945/2 626), 0.08%(2/2 626), 3.08%(81/2 626), 3.81%(100/2 626), (142.46±27.90) mmHg, 0.15%(4/2 626), 0.27%(7/2 626), 0.31(0.20, 0.50) mg/L). Age ((57.95±14.35) years old) and CK-MB (1.50(0.90, 3.25) μg/L) were significantly lower than those in the non-AAD group ((61.94±15.77) years, 2.50(1.24, 4.81) μg/L). The differences were statistically significant (the statistical values were χ 2=9.47, χ 2=25.46, χ 2=180.80, χ 2=81.11, χ 2=76.17, χ 2=975.60, χ 2=798.00, χ 2=44.72, t=6.28, χ 2=527.20, χ 2=93.22, Z=14.09, t=2.61, and Z=3.51, respectively; P values were 0.002, <0.001, <0.001, <0.001, <0.001, <0.001, <0.001, <0.001, <0.001, <0.001, <0.001, <0.001, 0.009, and <0.001, respectively). Multivariate analysis showed that history of hypertension ( OR=3.088, 95% CI:1.294-7.374), history of aortic disease ( OR=20.771, 95% CI:2.132-202.361), family history of aortic disease ( OR=266.425, 95% CI:17.610-4 030.851), sudden onset of symptoms ( OR=3.538, 95% CI:1.643-7.619), laceration pain ( OR=1 771.971, 95% CI:204.048-15 387.935), back pain ( OR=61.550,95% CI:27.987-135.367), abdominal pain ( OR=12.325, 95% CI:4.201-36.161), systolic blood pressure ( OR=1.026, 95% CI:1.013-1.039), bilateral blood pressure/pulse asymmetry ( OR=338.357, 95% CI:60.704-1 885.949) and D-dimer ( OR=1.241, 95% CI:1.176-1.309) were independent factors for the diagnosis of AAD in patients with chest pain (P values were 0.011, 0.009, <0.001, 0.001, <0.001, <0.001, <0.001, <0.001, <0.001, and <0.001, respectively). Furthermore, the nomogram model was constructed. ROC curve analysis showed that the area under the curve was 0.976 ( P<0.01), the specificity was 94.52%, and the sensitivity was 91.96%. The statistics of Homser-lemeshow was used to test the goodness of fit, which shows that the model can be fitted well (χ 2=2.928, P=0.939). The prediction model was verified by external validation data, and the area under the ROC curve was 0.934 ( P<0.01), indicating that the model had good prediction performance. Conclusions:History of hypertension, history of aortic disease, family history of aortic disease, sudden onset of symptoms, laceration pain, back pain, abdominal pain, systolic blood pressure, bilateral blood pressure/pulse asymmetry and D-dimer were independent factors for the diagnosis of AAD in patients with acute chest pain. The AAD early diagnosis nomogram model based on the above factors has good predictive performance.

Epidemiological survey of glaucoma among people over 40 years old in rural areas of Chongqing / 中华实验眼科杂志

Objective:To understand the prevalence and epidemiological characteristics of glaucoma among people over 40 years old in rural areas of Chongqing.Methods:From August to October 2018, a stratified cluster random sampling method was used to investigate the cases of glaucoma among people over 40 years old in a rural population of the Rongchang and Qijiang Districts in Chongqing.The subjects had been living in the local area for over ten years.Basic information for each patient, including gender and age was documented, and their visual acuity and intraocular pressure were routinely measured.The Van Herick method was used to evaluate the depth of the central and peripheral anterior chamber, a preset lens was used to examine the fundus, and the cup to disc ratio(C/D) of the optic disc was emphasized.All suspected glaucoma patients underwent further standard glaucoma examinations.This study protocol was approved by the Ethics Committee of the First Affiliated Hospital of Army Medical University.Results:A total of 4 680 people were identified, and 4 073 respondents participated in the survey, and the response rate was 87%.The prevalence of glaucoma was 1.72% (70/4 073). There were no significant differences in the prevalence of primary angle-closure glaucoma (PACG) and primary open angle glaucoma (POAG) between different genders ( χ2=0.042, P=0.837; χ2=2.838, P=0.092). The prevalence of glaucoma in people over 70 years old was 2.5%, significantly higher than that in other age groups.In patients with glaucoma, the rate of visual impairment was 68.57%(48/70), and the rate of blindness was 47.14%(33/70). There was no significant difference in the incidence of low vision between different types of glaucoma ( χ2=2.785, P=0.248), but there was a significant difference in the rate of blindness ( χ2=10.668, P=0.005). The highest rate of blindness was found in secondary glaucoma.The detection rate of intraocular pressure, anterior chamber depth and C/D was statistically significant ( χ2=43.325, P<0.001), and the positive rate of C/D was the highest.When the factors of intraocular pressure, and C/D were considered jointly, the detection rate of glaucoma could be increased to 55.88%. Conclusions:The prevalence of glaucoma is 1.72% among people over 40 years old in rural areas of Chongqing, the prevalence of PACG is lower than previously recorded, but the proportion of glaucoma-induced visual impairment is higher.In field screening, the morphological examination of the fundus optic nerve is very important for the diagnosis of glaucoma.

Efficacy of different ways of cocktail analgesic mixture injection on total knee arthroplasty / 中南大学学报(医学版)

OBJECTIVES@#To evaluate the efficacy of different ways of cocktail analgesic mixture injection on total knee arthroplasty (TKA).@*METHODS@#A total of 50 patients with knee osteoarthritis treated by TKA from July to September 2018 were randomly divided into two groups (=25). The Group 1 underwent anterior intra-articular injection before prosthesis implanted while the Group 2 underwent posterior intra-articular injection before prosthesis implanted. Visual Analogue Scale (VAS) of all patients for pain during activity and at rest, maximal flexion degree of the knee at the 48th h and the 72th h after surgery, the time of raise leg, usage rate of patient-controlled analgesia (PCA), and complications were evaluated and analyzed.@*RESULTS@#VAS for pain at rest of patients in the Group 1 was significantly less than that in the Group 2 at the 6th, 12th, and 24th h after surgery (all <0.05). Maximal flexion degree of the knee at the 48th h and the 72th h after surgery in the Group 1 was better than that in the Group 2 (both <0.05). The Group 1 costed less time than the Group 2 on the ability to perform an active straight leg raise (=0.027).@*CONCLUSIONS@#The anterior intra-articular cocktail analgesic mixture injection can strongly relieve the pain early after TKA, which can improve knee function and achieve painless rehabilitation in most patients, with safety.

The relationship between parental psychological flexibility and problem behaviors in primary school students: the mediating role of family functioning / 中华行为医学与脑科学杂志

Objective:To explore the relationship among the parental psychological flexibility, family functioning and pupils' problem behaviors, and to provide empirical evidence for improving pupils' problem behaviors.Methods:Parents of all pupils in two primary schools in Beijing were selected as subjects in a cluster and were asked to complete the parental psychological flexibility questionnaire(PPFQ), family assessment device(FAD) and Conners child behavior rating scale(CBRS). SPSS 24.0 and AMOS 24.0 were used to analyze the data by Chi-square test, Mann-Whitney U test, t test and confirmatory factor analysis.The Bootstrap method was applied to test the mediating effect. Results:The detection rate of pupils' problem behaviors was 18.72%.All children were divided into normal group( n=825) and problem group( n=190) by comparison with the norm.The PPFQ total score and dimension score of normal group were higher than those of problem group((86.67±13.57) vs(77.18±14.40), (43.65±8.71) vs (37.98±9.68), (13.26±4.70) vs(12.07±4.72), (29.75±4.50) vs(27.13±5.66), all P<0.01)), while The FAD total score and dimension score of normal group were lower than those of problem group((120.01±15.31) vs(129.34±15.75), (11.69±2.02) vs(12.19±2.29), (17.64±3.09) vs(19.25±3.60), (23.01±3.21) vs(24.68±3.33), (12.44±2.26) vs(13.65±2.73), (14.28±2.49) vs(15.76±3.07), (19.04±2.54) vs(19.92±2.62), (21.91±4.12) vs(23.88±4.15), all P<0.01)). The PPFQ total score of normal group and problem group were negatively correlated with the total scores of FAD and CBRS respectively( r=-0.47, -0.42, r=-0.49, -0.38, all P<0.01). The FAD total score of normal group and problem group were positively correlated with the CBRS total score respectively( r=0.37, 0.28, all P<0.01). The test of structural equation model showed that the intermediary model of FAD in normal group fits well(χ 2/ df=2.45, RMSEA=0.04, GFI=0.97, NFI=0.97, IFI=0.98, TLI=0.97). The path coefficients of PPFQ to FAD, CBRS and FAD to CBRS were significant( β=-0.62, -0.48, 0.12, P<0.01). The problem group fad intermediary model fitting was not good, however, PPFQ had significant influence on the path coefficients of FAD and CBRS respectively( β=-0.70, -0.56, P<0.01). Bootstrap analysis showed that the mediating effect of FAD in the relationship between PPFQ and CBRS was significant in the normal group(95% CI: -0.0854, -0.0408), accounted for 25.52% of the total effect.The mediating effect of FAD in the problem group was not significant. Conclusion:The parental psychological flexibility has a direct effect on family functioning and children's behavior in normal and problem children groups.Family functioning plays a part of mediating role between parental psychological flexibility and children's behavior in the normal group of children.

Effect of Zhenren-Yangzang decoction combined with moxibustion on spleen kidneydeficiency cold type diarrhea patients on the gastrointestinal function and intestinalmicroflora / 国际中医中药杂志

Objective To observe the effect of Zhenren-Yangzang decoction combined with moxibustion on the changes of gastrointestinal function and intestinal microflora of the patients with spleen kidney deficiency cold type diarrhea.Methods A total of 92 diarrhea patients were randomly divided into observation group and control group, with each group of 46 patients. The control group was given conventional western medicine treatment. Based on this, the observation group was given Zhenren-Yangzang decoction combined with moxibustion. Both groups were treated for 4 weeks. The bacteria in feces (Enterobacteriaceae, Enterococcus, Lactobacillus and Bifidobacterium), enzyme linked immunosorbent assay (ELISA) detection of serum gastrin and vasoactive peptide level, and the recurrence status were analyzed, and the clinical curative effect were evaluated.Results After treatment, the total effective rate was 93.5％ (43/46) in the observation group and 76.1％ (35/46) in the control group, which was significant difference between the 2 groups in total effective rate (Z=-3.217,P=0.009). After treatment, the serum gastrin level (37.55 ± 4.87 pg/mlvs. 35.08 ± 4.63 pg/ml,t=4.946) of the observation group was significantly higher than that of the control group, and the vasoactive peptide (18.13 ± 2.84 pg/mlvs. 22.49 ± 3.39 pg/ml,t=4.037) level was significantly lower than that of control group (P<0.05). The enterobacteriaceae in the observation group was significantly lower than that of the control group (t=3.392,P<0.05), and the enterococcus, Lactobacilli, Bifidobacterium in the observation group were significantly higher than those of the control group (t=3.392, 3.946, 3.164,P<0.05). The recurrence rate of the observation group was 4.7％ (2/43) at 1 months, and the recurrence rate was 11.6％ (5/43) at 3 months. The recurrence rate of the control group was 20％ (7/35) at 1 months, and the recurrence rate was 37.1％ (13/35) at 3 months. There were significant differences in the recurrence rate between the 2 groups at 1 months and 3 months (χ2=5.871, 7.082,P=0.015, 0.007).Conclusions The application of Zhenren-Yangzang decoction combined with moxibustion can improve gastrointestinal function and intestinal micro ecological environment, and reduce the recurrence rate of the patients with spleen and kidney deficiency cold type diarrhea.

Construction of nomogram map of survival risk of osteosarcoma patients based on SEER database / 中国医师杂志

Objective To construct a prognostic nomogram to predict 3-year and 5-year survival in patients with osteosarcoma.Methods A total of 1 671 patients with osteosarcoma diagnosed between 1988 and 2011 were collected from the National Cancer Institute program (SEER) database.They were randomly divided into nomogram model group (n =836) and verification group (n =835).Univariate and multivariate Cox were used to determine the independent prognostic factors in the model group,and then these factors were incorporated into the chart to predict the 3-year and 5-year survival rates of osteosarcoma patients.The consistency index (C-index) and calibration curve were used to verify the internal and external validation of the contour map and check its prediction accuracy.Results The age,tumor location,tumor size,pathological grade,distant metastasis and surgical procedure were the independent prognostic factors of osteosarcoma patients (P＜0.05).These factors were included in the chart and successfully constructed.The C index obtained by internal validation of the chart was 0.746 (95％ CI:0.719-0.773) and 0.709 (95％ CI:0.682-0.735) by external validation using the validation group.At the same time,the calibration curves of the two groups were consistent.Conclusions The nomogram map of the risk of osteosarcoma patients in this study has good predictive accuracy and helps orthopedics to evaluate the prognosis of patients with osteosarcoma more accurately.It will be beneficial to individualized diagnosis and treatment of osteosarcoma patients.

A new method measuring the rotation center of hip joint and its significance for hip replacement surgery / 中国医师杂志

Objective@#To design and evaluate a new method for measuring the center of rotation of the hip joint, and to compare it with the traditional methods.@*Methods@#Data of healthy hips of 120 total hip arthroplasty (THA) patients (120 hips) and bilateral hips of 20 healthy volumteers (40 hips) were collected. A series of X-rays and magnetic resonance imaging (MRI) were taken from each patient with the hip joint abductted at differenct angles (0°, 7.5°, 15°, and 22.5°). The motion track of rotation center was obtained by comparing these X-ray and MRI images. The preoperative and postoperative data of 67 surgical patients who underwent two different measurement methods before surgery were compared.@*Results@#Compared with traditional measurement methods, the accuracy of our new method was significantly improved; the results of hip MRI verified the objectivity and accuracy of our new method; preoperative measurements and postoperative follow-up results showed that our new method had a better clinical effect than traditional measurements.@*Conclusions@#The team′s innovative new measurement method based on pelvic orthotopic X-ray photographs with different abduction angles of the hip shows more accurate data than traditional measurement methods and shows better clinical results.

A new method measuring the rotation center of hip joint and its significance for hip replacement surgery / 中国医师杂志

Objective To design and evaluate a new method for measuring the center of rotation of the hip joint,and to compare it with the traditional methods.Methods Data of healthy hips of 120 total hip arthroplasty (THA) patients (120 hips) and bilateral hips of 20 healthy volumteers (40 hips) were collected.A series of X-rays and magnetic resonance imaging (MRI) were taken from each patient with the hip joint abductted at differenct angles (0°,7.5°,15°,and 22.5°).The motion track of rotation center was obtained by comparing these X-ray and MRI images.The preoperative and postoperative data of 67 surgical patients who underwent two different measurement methods before surgery were compared.Results Compared with traditional measurement methods,the accuracy of our new method was significantly improved;the results of hip MRI verified the objectivity and accuracy of our new method;preoperative measurements and postoperative follow-up results showed that our new method had a better clinical effect than traditional measurements.Conclnsions The team's innovative new measurement method based on pelvic orthotopic X-ray photographs with different abduction angles of the hip shows more accurate data than traditional measurement methods and shows better clinical results.

Improvement Effects of SPD System on the Implementation of “Two-invoice System ”in Drug Procurement in Our Hospital / 中国药房

OBJECTIVE： To provide reference for promoting the implementation of “two-invoice system” for drug purchase in medical institutions. METHODS： The function of confirmation， enquiry， statistics for “two-invoice system” of drug purchase order were added into relevant module of SPD （supply processing distribution） system to realize the management of “two-invoice system” data by means of information technology. By analyzing the data of the “two-invoice system” of Shanxi dayi hospital （our hospital） from Aug. 2017 to Jun. 2018， the effects of SPD system on “two-invoice system” of drug purchase in our hospital were introduced after the application of SPD system. The effects of SPD system were evaluated in respects of work efficiency， accuracy rate and resource saving， etc. RESULTS： SPD system was used for the management of “two-invoice system” to realize the information management of invoices. The time for checking “two-invoice system” information was shortened from 1.5 min/sheet to 0.1 min/sheet； the accuracy rate was increased from 95％ to 100％， and about 40 000 sheets of paper were saved each year. CONCLUSIONS： The application of SPD system in “two-invoice system” of drug purchase can improve the work efficiency， reduce the labor cost and reduce the waste of resources， it effectively improves the level of management in our hospital.

Expression and Clinical Significance of Serum 25-OH-D in pregnant women with SCH [Subclinical Hypothyroidism] and GDM [Gestational Diabetes Mellitus]

Objective: To analyze the level and clinical significance of serum 25-hydroxyvitamin D [25-OH-D] levels in pregnant women with subclinical hypothyroidism [SCH] and gestational diabetes mellitus [GDM]

Methods: One hundred pregnant women of 24-28 weeks' pregnancy with SCH combined GDM were selected into the observation group, and 100 healthy pregnant women were selected into the control group during the corresponding period. Examined the thyroid stimulating hormone [TSH], free thyroxine [FT4], 25-OH-D, serum calcium [Ca2+], fasting plasma glucose [FPG], and glycosylated hemoglobin [HbAIc] levels and thyroid peroxide antibody [TPOAb], Thyroglobulin antibody [TgAb] status. Examine and compare TSH, FT4, Ca2+, FPG, HbAIc, TPOAb, and TgAb at different levels of serum 25-OH-D in the observation group. Compared the 25-OH-D levels and the ratio of different contents of 25-OH-D of TPOAb-positive and TgAb-positive SCH pregnant women

Results: The levels of TSH, FPG and HbAIc in the observation group were significantly higher than those in the control group [P<0.01]. Through comparison of FT4 levels between the two groups, the difference had no statistical significance [P>0.05]. The levels of 25-OH-D and Ca2+ in the observation group was significantly lower than those in the control group, and the difference had statistical significance [P<0.01]. Through comparison of TSH, Ca2+, FPG and HbAIc in groups with different serum 25-OH-D levels, the difference had statistical significance [P<0.01]. The positive rates of TPOAb and TgAb of pregnant women in the observation group were higher than in the control group [P<0.05]. The vitamin D deficiency rate of TPOAb or TgAb positive pregnant women in the observation group was higher than those in the TPOAb or TgAb negative pregnant women, the difference had statistical significance [P < 0.05]

Conclusion: blood glucose level in pregnant women with GDM and SCH increased significantly, blood calcium level decreased significantly. This group of people are more likely to have VitD deficiency. Thyroid stimulating hormone and blood glucose levels in pregnant women are negatively correlated with VitD levels. Therefore, serum 25-OH-D level can be used as an important reference index for gestational diabetes mellitus with subclinical hypothyroidism, and it has great clinical significance to maintain it at a normal level

A preliminary study of validity and reliability of the Chinese version of the Parental Psychological Flexibility Questionnaire / 中国心理卫生杂志

Objective:To revise the Chinese version of the Parental Psychological Flexibility Questionnaire (PPFQ) and test its validity and reliability.Methods:Totally 1015 parents from 2 primary school of Beijing were recruited and asked to complete the Chinese version of PPFQ.Item analysis was conducted to identify valid items.The parents were randomly allocated into two groups where one subset (n =510) was used for exploratory factor analysis (EFA),and the other (n =505) for confirmatory factor analysis (CFA) and discriminant validity.In addition,responses of 389 participants selected by simple random sampling was assessed in criterion validity with the Cognitive Fusion Questionnaire (CFQ),Acceptance and Action Questionnaire-Second Edition (AAQ-Ⅱ]),Self-Rating Anxiety Scale (SAS),Self-Rating Depression Scale (SDS),Mindful Attention Awareness Scale (MAAS),Trait Coping Style Questionnaire(TCSQ) and Conners Child Behavior Rating Scale (CBRS).Seven weeks later,225 of the participants were retested.Results:The exploratory factor analysis extracted 3 components,and explained 58.1％ of the total variance.The factor loading of items ranged between 0.63 and 0.86.The confirmatory factor analysis verified the 3-factors model (x2/df=1.77,NFI =0.94,IFI =0.97,GFI =0.96,TLI =0.96,CFI =0.97,RMSEA =0.04).Discriminant validity testing demonstrated the three revised factors had adequate discriminant validity in relation to one another (Ps ＜ 0.01).Criterion validity results showed that the total and subscale scores of the PPFQ were negatively correlated with the scores of CFQ,AAQ-Ⅱ,SAS,SDS,TCSQ-NC,CBRS (r =-0.16--0.52,Ps ＜ 0.01),and were positively correlated with the scores of MAAS,TCSQ-PC (r =0.14-0.37,Ps ＜ 0.01).The total and subscale scores of the PPFQ demonstrated good internal consistency Cronbach's α were 0.77-0.86 and test-retest reliability coefficient were 0.55-0.75.Conclusion:It suggests tthe validity and reliability of the adapted Chinese version of the Parental Psychological Flexibility Questionnaire be satisfactory,and could be used in the clinical and research work in China.

Comparative analysis of eight year clinical medical professionals training —a case study of Xiangya School of Medicine, Central South University / 中华医学教育探索杂志

As one of the first pilot eight-year clinical medicine education institutions, Xiangya School of Medicine has already put it into practice for almost 12 years. After years exploring and reforming, its cultivating plan has already been built up. This paper will make a brief comparative analysis between 2004 version and 2012 version in cultivating objectives, model and characteristics, demonstrated the development and reform of its eight-year program education, shown its features such as strengthening the basic knowledge, emphasizing the clinical skills, cultivating the capabilities, and broadening the international perspectives, and attempt to contact the residency and research training, in order to provide the reference for the eight-year program education reform.

Analysis of the results in control of coal-burning-borne endemic fluorosis in Shangli County and Yuanzhou District of Jiangxi Province in 2014 / 中华地方病学杂志

Objective To evaluate the control effects on coal-burning-borne endemic fluorosis in Shangli County and Yuanzhou District of Jiangxi Province in 2014.Methods Self-evaluation at the county level was carried out in all diseased villages in Shangli County and Yuanzhou District,including 145 villages of Shangli County and 32 villages of Yuanzhou District.Review at the provincial level was based on the results of selfevaluation of the county,3 towns were chosen in each county (district),3 villages were chosen in each town,a total of 18 villages were re-checked in Shangli County and Yuanzhou District,and 10 households were chosen to recheck in each village.According to the project requirements for endemic disease control,in all diseased villages of Shangli County and Yuanzhou District,self-evaluation results of the county was used to evaluate the status of the improved and the used stoves,and dental fluorosis of children aged 8-12.Review at the provincial level was carried,and the results were evaluated based on the Standards for Control Criteria for Endemic Fluorosis Areas (GB 17017-2010) and Elimination of Coal-burning-borne Endemic Fluorosis.Results Self-evaluation of the county:110 443 households in Shangli County and 20 280 households in Yuanzhou District were investigated,the qualified rates of improved stoves were 92.45％ (102 109/110 443) and 98.28％ (19 932/20 280),respectively;the correct-usage rates of qualified stoves were 93.46％ (95 427/102 109) and 98.47％ (19 627/19 932),respectively.Dental fluorosis of 28 772 children were examined,the number of dental fluorosis was 5 730,the prevalence rate of dental fluorosis was 19.92％ (5 730/28 772);Shangli County and Yuanzhou District were up to the standard of fluorosis control,the rates of control were 95.17％ (138/145) and 100.00％ (32/32),respectively.Review at the provincial level:180 households were selected,the qualified numbers of improved stoves and the correct-usage of qualified stoves were 179 and 177,respectively,the qualified rate of improved stoves was 99.44％ (179/180) and the correct-usage rates of qualified stoves was 98.88％ (177/179).Dental fluorosis of 805 children were examined,the number of dental fluorosis was 139,the prevalence rate of dental fluorosis was 17.27％ (139/805).The consistency rate of county-level and provincial-level was 88.89％ (16/18).Conclusion The control efficiency for coal-burningborne fluorides in Shangli County and Yuanzhou District of Jiangxi Province is obvious,the prevalence is under control.

Risk assessment of secondary transmission induced by imported malaria in Jiangxi Province / 中国血吸虫病防治杂志

@#Objective To assess the risk of secondary transmission induced by imported malaria in Jiangxi Province，so as to provide the evidence for adjustment of malaria surveillance strategies in the key groups and areas. Methods The Delphi method was used to establish the secondary transmission risk indicator system and the weight of each index was obtained. The data of malaria prevalence，vector distribution and intervention capacity were collected in 100 counties of Jiangxi Province from 2012 to 2015. The transmission potential index（TPI），intervention capacity index（ICI），and malaria risk index（MRI）were calculated for each county. The risk map was drawn with GIS software. Results The top ten counties with highly potential risk indicators were Linchuan District（2.131），Xinzhou District（1.609），Jiujiang County（1.404），Zhanggong District（1.365）， Fengcheng City（1.225），Qingshanhu District（1.184），Yudu County（1.171），Dingnan County（1.018），Xunyang District（1.015）and Zhushan District（1.006）. The high risk areas were mainly distributed in the regions of the capitals of their prefectures and in counties with more floating population. Conclusions There are the risk of the secondary transmission induced by imported malaria in Jiangxi Province. The high risk of the secondary transmission is shown in the areas with more floating population and weaker intervention capacity.

Three new lignan glucosides from the roots of Scutellaria baicalensis

Three new lignan glucosides, baicalensinosides A-C (1-3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofuran-type lignan glycoside with a mono-hydroxyl substitution at the 7'-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin (OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1-3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.

Investigate and analysis on cognition to the knowledge of peripheral venous indwelling needles of ;clinical nurses in a certain grade A class three hospital / 中国实用护理杂志

Objective To investigate the cognition level of clinical nurses to peripheral venous indwelling needles, and provide a reference for nursing administrators to carry out targeted intravenous catheter standardized training operation. Methods By convenience sampling, 129 clinical nurses of the certain grade A class three hospital were selected, and their perception about indwelling intravenous catheter were investigated by using self-designed questionnaire in November 2015. Results 125 questionnaires were effectively rewnered. Average score of 125 nurses′cognition to indwelling intravenous catheter was (57.52 ± 10.23) points, pass rate was 65.6%(82/125), and influencing factors were education background, the job tittle, work experience and so on. Conclusions The clinical nurses′assessment, cognition and knowledge master to indwelling intravenous catheter is not ideal, lacking a comprehensive clinical peripheral venous catheter assessment tools. Clinical nurse managers should focus on strengthening vein management, reasonable and better trained clinical nurse intravenous catheter cognitive level, so as to ensure that the effect of catheter using.

Epidemiological characteristics of malaria in Jiangxi Province, 2010-2014 / 中华地方病学杂志

Objective To analyze the epidemiological characteristics of malaria in Jiangxi Province from 2010 to 2014 and to provide a reference for malaria control in the whole province.Methods Data on malaria cases in Jiangxi Province from 2010 to 2014 were collected through the Disease Reporting Information System of Chinese Center for Disease Control and Prevention and Information System for Parasitic Diseases Control and Prevention.Descriptive epidemiological method was used to analyze the area distribution,time distribution and population distribution of the malaria cases.Results A total of 218 malaria cases were reported from 2010 to 2014 in the province,with an annual mean incidence of 0.097 3/100 000.One dead case was reported with a fatality rate of 0.46％(1/218).Of all 11 prefectures and 100 counties (cities,districts) in Jiangxi,65 counties (cities,districts)reported malaria cases.The top three counties (cities,districts) of malaria cases were Qingshanhu (22),Nanchang (15)and Jinxian (13),totally accounting for 22.94％ (50/218).The cases were reported through the whole year,without obvious seasonal peak.The ratio of male to female was 30.14:1.00.The age of the cases mainly distributed around the ages of 20-＜ 60 years,accounting for 94.49％ (206/218).The peak appeared in 40-＜ 50 years group,accounting for 32.11％ (70/218).The three major occupations of the cases were farmer,worker and migrant worker (131,60.09％).The cases were mainly imported from Africa and Southeast Asia,whose proportion of imported cases was 76.19％ (160/210) and 19.52％ (41/210),respectively.Conclusions The incidence of malaria is stable with a slight increase in Jiangxi Province from 2010 to 2014.Control of imported malaria cases will be the main task in the future.

Relationship between cognitive fusion and the state of anxiety and depression in perinatal women / 中华行为医学与脑科学杂志

Objective To explore the relationship between cognitive fusion and the state of anxiety and depression of perinatal women and to provide empirical evidences for acceptance and commitment therapy in mental treatment of anxiety and depression in perinatal women.Methods 309 perinatal women collected by cluster random sampling were assessed with self-made general information questionnaire,Self-Rating Anxiety Scale (SAS),Self-Rating Depression Scale (SDS) and Cognitive Fusion Questionnaire (CFQ) in predelivcry period and 3-7 days after childbirth respectively.Results (1) CFQ scores in the predelivery or postpartum anxiety group ((32.18±10.78),(31.54±10.30))were higher than that in the normal group((21.49±9.56),(20.84±9.82)),and the difference was statistically significant (t=-8.26,-8.22;all P=0.000);CFQ scores in the predelivery or postpartum depression group ((26.74 ±11.76),(26.84 ± 12.11)) were higher than that in the normal group((23.06± 10.33),(21.79±9.90)),and the difference was statistically significant(t=-2.76,-3.71;P=0.006,0.000).(2)It was found that the predelivery or postpartum CFQ scores were positively associated with the SAS scores of predelivery periods and postpartum periods respectively(r=0.51,0.45,0.50,0.55;P=0.000);the predelivery or postpartum CFQ scores were positively associated with the SDS scores of predelive1y periods and postpartum periods respectively (r =0.26,0.31,0.21,0.38;P =0.000).(3) Hierarchical multiple regression analyses were then conducted.The predelivery CFQ had a significant effect on postpartum SAS(△R 2=0.02,P=0.006)and postpartum SDS respectively(△R 2=0.02,P=0.006),and the regression equations were statistically significant.Conclusion A function to predict the occurrence of matemal postpartum anxiety and depression is obtained from the cognitive fusion which is attributed to the risk of maternal postpartum anxiety and depression.