RESUMEN
Buprenorphine, a synthetic derivative of Thebaine, is a strong new analgesic agent. It was compared with pethidine in doudle-blind trial of 86 burn and plastic patients with severe or moderate pain. The result showed that the analgesic effect of Buprenorphine 0.3 mg I. M. appeared superior to Pethidine 50mg ( P
RESUMEN
The basic pain threshold and pain tolerance were measured by use of radiant heat stimulation in healthy volunteers, which were close to normal distribution. The stability was obtained by repeated determination for same individuals in different time. With this method, a clinical assessment of analgesic drugs was carried out among healthy volunteers. Acetaminophen-Codeine tablet ( 2 tablets ) was able to depress pain response by increasing pain threshold and tolerance of 23% and 12% ( P