RESUMEN
Aphanamixis grandifolia, a perennial herb of genus Aphanamixis (Meliaceae), has the effect of relaxing sinew and activating collaterals, dredging arthralgia, expelling wind-evil and removing wetness, etc. Previous phytochemical investigations on this plant resulted in the isolation of various terpenoid derivatives, including limonoids, tirucallane-type, dammarane-type, and cycloartane-type triterpenoids, as well as diterpenoids and sesquiterpenoids. Moreover, bioactivities of those compounds were evaluated, which displayed extensive biological properties, such as antibacterial, insecticidal, antineoplastic, anti-inflammatory, antimalarial, and antibacterial activities, etc. In this paper, the systematic classification, chemical constituents, and biological activities of A. grandifolia were summarized. It may provide the reference for the further studies of this plant.
RESUMEN
Three active compounds were isolated from the marine bryozoan Bugula neritina living in the South China Sea by bioassay-guiding isolation method with a combination of extraction with suitable solvent and multiple column chromatography(Sephadex LH-20, ODS and preparative HPLC). Their structures were assigned as known bryostatin 4, bryostatin 5 and bryostatin 6 by intensive analysis of the data of high resolution 2DNMR(600 MHz,DQF-COSY,TOCSY,HMQC and ROESY). All these compounds were obtained from this bryozoan in the South China Sea for the first time and showed significant antineoplastic activities in vitro.