RESUMEN
Topical antibiotic like Calcium mupirocin and its combination with steroid Fluticasone are commonly used to treat burn wounds. But whether they influence healing of wounds is not known. Aim: To compare the effect of Calcium mupirocin and Fluticasone of Apex Laboratories Chennai, on experimentally induced burn wound healing in Wistar rats and compare with available market preparation Mupirocin and Fluticasone -mupirocin combination. Method: Partial thickness burn wound was inflicted, on Wistar rats under ketamine (50mg/kg/i.p) by pouring hot molten wax at 80◦ C into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals with partial thickness burn wounds were divided into 7 groups (n=10). Group I did not receive any drug and served as control group. Group II, III, IV, V, VI, and VII received Calcium mupirocin A, Calcium mupirocin B, Mupirocin, Fluticasone+Calcium mupirocin A combination. Fluticasone +Calcium mupirocin B combination and Fluticasone -mupirocin combination creams respectively, twice a day for 21 days or till complete healing whichever was earlier. Results: Calcium mupirocin significantly decreased the duration of epithelialization and increased % of wound contraction in comparison to the control group. This was confirmed by Histopathology studies. Conclusion: Calcium mupirocin of apex possess significant wound healing properties.