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Objective:To understand the reserves of wild resources and artificial cultivation of Curcuma aromatica Salisb. in Guangxi, so as to provide basis for the conservation, rational development and utilization of germplasm resources of Curcuma aromatica Salisb. in Guangxi. Methods:By using literature retrieval and field investigation methods to analyze of geographic distribution, growing environment and community of Curcuma aromatica Salisb. in Guangxi. Results:Wild Curcuma aromatica Salisb. has strong adaptability and is growing in limestone mountains, earthen hills and plains. It usually grows at the foot of mountains or the edge of gullies or on the farmland or along the roads. It has a strong adaptability to altitude, soil type. The habitat of wild Curcuma aromatica Salisb. has been destroyed by human reclamation. Conclusion:The geographical distribution, growing environment and community of wild resources of Curcuma aromatica Salisb. in Guangxi were known, which provids the reference for the conservation, development and utilization of Curcuma aromatica Salisb.
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Objective To investigate the effect of Curcuma aromatica ethylacetate extracts (CAEE) on myocardial ischemia reperfusion injury in rats. Methods The myocardial ischemia-reperfusion (I/R) injury model was established by the ligation and release of descending coronary artery in rats. I/R rats were equally divided into seven groups (i.e model group, four CAEE groups with 0.5, 1, 2, and 4 g/kg, two positive control groups with Di’ao Capsule or isosorbide mononitrate) with 10 rats in each group. In addition, 10 rats without I/R were arranged as Sham group. Each group was treated with corresponding drugs once daily for 7 d. The myocardial infarction area, cardiac function and cardiac geometric alteration were measured. Serum LDH and CK-MB were measured by chemical method and enzyme linked immunosorbent assays. The oxidative stress cytokines involving serum SOD, MDA, and GSH were measured by chemical methods. The myocardial tissue lesion was observed by histopathology. Results Compared with model group, myocardial infarction area was decreased in CAEE group with 1, 2, and 4 g/kg (crude drug), and the ejection fraction (EF) and the left ventricular pressure maximum rise/fall rates ( ± LVdp/dtmax) were increased in different degree treated with CAEE. Serum CK-MB and LDH were decreased in CAEE group. The oxidation/anti-oxidation balance can be adjusted by CAEE administration, the ratios of serum SOD/MDA and GSH/MDA were increased accompanying with trend increasing of SOD and GSH. The light microscopic myocardial tissue edema levels and inflammatory cell infiltration were significantly lightened in the CAEE group than the model group. Conclusion CAEE showed therapeutic benefits on rats in myocardial ischemia-reperfusion injury via the potential mechanism of balance status of oxidation and anti-oxidation.
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This article reports an ecofriendly approach for the synthesis of Ag nanoparticles (Ag NPs) using aqueous leaf extract of Curcuma aromatica. The synthesized Ag NPs were characterized using UV-visible spectroscopy, FTIR, XRD and TEM analyses. UV–Visible spectra of the aqueous medium containing Ag NPs showed a gradual decrease of the absorbance peak observed at 442 nm. The biomolecules responsible for the reduction of Ag NPs were analyzed by FTIR. XRD result confirmed the presence of AgNPs with FCC crystal structure. The calculated crystalline size using Scherrer formula is in the range from 20 to 80 nm. TEM analysis ascertained spherical nature of the Ag NPs. The synthesized Ag NPs exhibited good antibacterial performance against gram-positive and gramnegative bacteria strains, which was studied using standard disc diffusion method. The synthesis of Ag NPs by this method is rapid, cost effective and can be used for various applications.
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The protective effects of Curcuma aromatica leaf extract were studied on nehrotoxicity induced by arsenic trioxide in albino rats. LD50 estimated for arsenic trioxide was 14.98 mg kg-1 body weight. Nephrotoxicity was assessed by estimating the serum levels of urea, uric acid and creatinine, the markers of renal dysfunctioning. The applied doses of arsenic trioxide administered orally were 0.007 , 0.01 , 0.02 and 0.15 mg 100 g-1 body weight for sub acute (21,14 and 7 days) and acute (1 day) treatments respectively. Arsenic trioxide intoxication significantly increased the serum level of urea, uric acid and creatinine in comparison to control due to renal dysfunctioning. Pretreatment with dose of 50 mg kg-1 body weight of leaf extract of Curcuma aromatica restored the increased serum levels of urea, uric acid and creatinine to normal. The results reveal that Curcuma aromatica leaf extract has a potential to modulate the renal dysfunctioning caused by arsenic trioxide.
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[Objective] To study the effects of different growth periods on the contents of volatile oil and the curcumol in Curcuma aromatica Salisb. samples,which provided theoretical bases to control the quality of the crude drug of Curcuma aromatica Salisb.[Method]The contents of volatile oil in Curcuma aromatica Salisb. samples were determined by the method of Pharmacopeia,and HPLC method for determination of curcumol in different samples was established. [Result]The contents of volatile oil in different samples lied in the range of 0.820%～0.471%(g/g),and the contents of curcumol in different volatile oil samples were between 0.862%(g/g) and 1.380%(g/g). [Conclusion]Compared with the Curcuma aromatica Salisb. of a shorter growing period,the contents of longer growth period were higher.Different growing time had effects on the accumulating of volatile oil and the curcumol in Curcuma aromatica Salisb.
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Through several murine transplantable tumor models, we studied the immunoprotective effect and mechanism of action of specific active immunization with various tumor cell vaccines (TCV) treated by: (1) Oleum Curcuma Aromatica (OCA, a Chinese anticancer medicament) and its effective monomer ?-elemene; (2) MMC and glutaraldehyde; (3) ~(60)Co and X-ray irradiation; and (4) vaccinia virus (VV) and newcastle disease virus (NDV), including virus infected TCV membrane fraction (Mfr). The reproducible results of immunoprotective effect indicated that the specific active immunotherapy with such TCVs might be of practical value in clinical immunological approaches to cancer therapeutics.