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Introduction: the first COVID-19 case in Brazil was confirmed on February 26, 2020. As of March 17, 2023, the Ministry of Health reported 699,634 deaths from COVID-19, with a case fatality rate of 1.9%. The impact of the COVID-19 pandemic in Brazil extends to socioeconomic and healthcare systems, reflecting significant regional disparities. Objective: To analyze mortality, incidence, and case fatality rates for COVID-19 in the states of Paraná and Santa Catarina, in the southern region of Brazil. Methods: This is an ecological time-series study using official Brazilian secondary data for COVID-19 cases and deaths. Data were extracted from the dashboard of the State Health Department of Santa Catarina and Paraná. Temporal series were developed for trend analysis using the Prais-Winsten regression model. Statistical analyses were performed using STATA 14.0 software (College Station, TX, USA, 2013). Results: In the analysis of rates over the entire period, trends for mortality, case fatality, and incidence in the state of Santa Catarina are decreasing, decreasing, and stationary, respectively. In Paraná, rates over the entire period showed a stationary trend for mortality, decreasing for case fatality, and increasing for incidence. Conclusion: COVID-19 had a devastating effect on the states of Santa Catarina and Paraná. Both states experienced the progression of the COVID-19 pandemic, with higher case fatality and mortality rates observed in Paraná, while Santa Catarina had a higher incidence rate over the three years of the COVID-19 pandemic.
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Introduction: The AIDS epidemic has undergone several transformations, and, in recent years, there has been an increase in cases of HIV/AIDS among adolescents and young people. Thus, it is essential to know this population to base health actions scientifically.Objective: This study aims to analyze the epidemiological profile of adolescents living with HIV/AIDS in Espírito Santo, Brazil.Methods: A descriptive, sectional study in which notifications of HIV/AIDS among adolescents aged 13 to 19 between 2010 and 2020 were analyzed.Results: 523 adolescents with HIV/AIDS were found in the analyzed period (an average of 47 cases/year). There was a predominance of male adolescents (68.8%), older than 16 years (mean=18.0 years), of mixed race/colour (54.6%), living in the metropolitan region near the capital. It was observed that the schooling of females is lower, with 47.2% of them in elementary school, while 45.0% of the boys are in high school. In most cases, the infection occurred via sexual intercourse, among men, through homosexual relations (55.0%), and among women, through heterosexual relations (82.2%). The HIV viral load was detectable in almost all (84.8%) cases, and 11 (6.8%) of these adolescents died.Conclusion: The epidemiological profile of HIV and AIDS cases among adolescents in Espírito Santo shows a higher frequency of cases in males aged 16 to 19 years, with incomplete high school education, who acquired HIV through unprotected sex in homosexual relationships. We highlight the high percentage of young people with detectable viral loads and deaths due to complications of AIDS
Introdução: A epidemia da AIDS passou por diversas transformações e, nos últimos anos, observa-se aumento de casos de HIV/AIDS entre adolescentes e jovens. Assim, é fundamental conhecer essa população para embasar cientificamente as ações em saúde. Objetivo: analisar o perfil epidemiológico de adolescentes que vivem com HIV/AIDS no Estado do Espírito Santo, Brasil. Método: estudo descritivo, seccional, no qual foram analisadas notificações de HIV/AIDS entre adolescentes de 13 a 19 anos, entre 2010 e 2020.Resultados: foram encontrados 523 adolescentes vivendo com HIV/AIDS no período analisado (média de 47 casos/ano). Prevaleceu os adolescentes do sexo masculino (68,8%), com mais de 16 anos (média=18,0 anos), de raça/cor parda (54,6%), residentes na região metropolitana, próxima a capital. Foi observado que a escolaridade do sexo feminino é menor, estando 47,2% delas no ensino fundamental, enquanto 45,0% dos rapazes já estão no ensino médio. Em grande parte dos casos a infecção ocorreu via sexual, sendo, entre os homens, através de relações homossexuais (55,0%) e entre as mulheres por meio de relações heterossexuais (82,2%). A carga viral de HIV foi detectável em quase totalidade (84,8%) dos casos e 11 (6,8%) destes adolescentes evoluíram para óbito. Conclusão: O perfil epidemiológico dos casos de HIV e AIDS, entre os adolescentes, no Estado do Espírito Santo, demonstra maior frequência de casos no sexo masculino, na faixa etária de 16 a 19 anos, com ensino médio incompleto, que adquiriram HIV por via sexual desprotegida, em relações homossexuais. Destaca-se a alta porcentagem de jovens com carga viral detectável e os óbitos em decorrência de complicações da AIDS.
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Background & objectives: Endometrial serous carcinoma (ESC) is a high-grade epithelial neoplasm with increased risk for metastasis and recurrence. This study was aimed to assess various histomorphological features of ESC and their clinicopathological association with disease-free survival (DFS) and overall survival (OS). Methods: A total of 205 slides (belonging to 120 patients) diagnosed as ESC from January 2009 to December 2015 were reviewed. Receiver operating characteristics (ROC) curves were established for the diagnostic performance of depth of invasion (DOI), tumour-free distance (TFD) to serosa and percentage myometrial invasion (MI%). OS and DFS were generated by Kaplan-Meier curves and prognostic significance by Cox regression analysis. Results: The mean age at diagnosis was 61.8 yr and the mean tumour size was 4.01 cm. Majority of the females were multiparous (84%; n=94) and postmenopausal (89.2%; n=107). On histopathology, <50 per cent of MI was identified in 37 of the 104 (35%), while 62/104 (59.61%) patients had ?50 per cent MI. Seven (6.7%) patients had full-thickness invasion with serosal involvement, while five (4.8%) patients had no microscopic MI (minimal uterine serous carcinoma). Information about MI was not available in 16 patients. TFD ?7.0 mm, DOI ?6.0 mm and MI% ?40 were significant variables in univariate analyses for OS; however, on multivariate analysis; none of these turned out to be an independent predictor in terms of OS. For DFS, DOI (?6.0 mm) and MI% (?40%) showed a significant association, in univariate as well as multivariate analysis; however, TFD (?7.0 mm) did not show any significant association with DFS. Follow up data were available in 111 of the 120 (92.5%) patients with a five-year OS and DFS of 22.2 and 17.2 per cent, respectively. Interpretation & conclusions: Conventionally calculated DOI (less than or more than half thickness) did not show significance in the present study. Thus, calculating the actual myometrial DOI, MI% and TFD to serosa have the potential for contributing meaningfully to prognostication of ESC
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@#[Abstract] Objective:To detect the expression of transcription factor FOXP4 (Forkhead box P4) in laryngeal squamous cell carcinoma (LSCC) tissues and cell lines, and to investigate its effects on the proliferation, migration, invasion, cell cycle, and apoptosis of LSCC TU177 cells in vitro as well as to explore its relationship with epithelial-mesenchymal transition (EMT) process. Methods: A total of 40 pairs of tumor tissues and adjacent tissues that resected from LSCC patients were collected from the biological specimen bank of the Forth Hospital of Hebei Medical University between 2013 and 2015. The expression of FOXP4 in LSCC tissues and corresponding adjacent tissues was detected by qPCR. qPCR and Western blotting were used to detect the FOXP4 expression level in human LSCC cell lines (AMC-HN-8, TU177, TU686, and TU212). Small interfering RNA (si-RNA) was used to knock down FOXP4 expression in TU177 cells. The effects of FOXP4 knockdown on the proliferation, migration, invasion, cell cycle and apoptosis of TU177 cells were measured by MTS assay, clone formation assay, Transwell chamber migration and invasion assay, and flow cytometry, respectively. The mRNA levels of EMT markers N-cadherin, β-catenin, Vimentin, Twist, Snail and zine finger E box binding homeobox 1 (ZEB1) after transfection of si-FOXP4 in TU177 cells were detected by qPCR. The changes of protein levels of N-cadherin, β-catenin, Vimentin and Twist after FOXP4 knockdown were measured by Western blotting. Results: The expression of FOXP4 in LSCC tissues was significantly higher than that in adjacent tissues (P<0.05), and it was related to the TNM stage of tumors and lymph node metastasis (all P<0.05). The expression of FOXP4 in LSCC cells was higher than that in the adjacent tissues (P<0.05 or P<0.01). The expression of FOXP4 in TU177 cells transfected with si-FOXP4 was significantly lower than that in the control group (P<0.01). Compared with the control group, knocking down FOXP4 could inhibit the proliferation, migration and invasion but promote the apoptosis of TU177 cells in vitro (all P<0.01), block the cell cycle at G0/G1 phase (P<0.01), and reduce cell replication in S phase (P<0.01); in addition, knocking down FOXP4 could reduce the mRNA levels of N-cadherin, β-catenin, Vimentin, Twist, Snail, ZEB1 (P<0.05 or P<0.01) and the protein levels of N-cadherin, β-catenin, Vimentin, Twist in TU177 cells. Conclusion: The high expression of FOXP4 may be related to the occurrence and development of LSCC. FOXP4 knockdown can inhibit the proliferation, migration and invasion of laryngeal cancer cells in vitro, block cell cycle at G0/G1 phase, promote apoptosis, and may participate in the EMT process.
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Objective: To analyze the clinical outcome and the prognostic factor in pediatric patients with core binding factor-acute myeloid leukemia (CBF-AML). Methods: A total of 121 newly diagnosed pediatric CBF-AML patients enrolled from Aug. 2005 to Sep. 2017 were retrospectively reviewed. Cumulative incidence of relapse (CIR), event-free survival (EFS) and overall survival (OS) rates were estimated by Kaplan-Meier method and prognostic factors were evaluated by Cox regression with SPSS. Results: Of the 121 patients, 120 patients were assessed for bone marrow remission after induction chemotherapy. 100 cases (83.3%) achieved complete remission (CR) after the first course of chemotherapy. 119 cases (99.2%) achieved CR after the second course of chemotherapy. Of the 121 patients, 13 patients (10.7%) had recurrence with the median interval of recurrence as 13.8 months (3.7 to 58.8 months). 17 patients (14.0%) died. The CIR, EFS and OS at 3 years were 12.7%, 77.5% and 82.8%, respectively. The factors including age at diagnosis, sex, initial WBC count, presence of extramedullary leukemia, C-KIT expression, additional chromosomal abnormalities, and CR after the first course of chemotherapy were analyzed by multivariate regression analysis of Cox. Multivariate analysis identified that additional chromosomal abnormalities was the only independent risk factor affecting OS (HR=4.289, 95%CI 1.070-17.183, P=0.040). Conclusions: Pediatric CBF-AML was a unique setting of prognostic subtypes. Chemotherapy produced good responses. Additional chromosomal abnormalities was the only independent risk factor for OS in pediatric CBF-AML.
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Niño , Humanos , Factores de Unión al Sitio Principal , Supervivencia sin Enfermedad , Leucemia Mieloide Aguda , Pronóstico , Inducción de Remisión , Estudios RetrospectivosRESUMEN
Objective@#To analyze the clinical outcome and the prognostic factor in pediatric patients with core binding factor-acute myeloid leukemia (CBF-AML).@*Methods@#A total of 121 newly diagnosed pediatric CBF-AML patients enrolled from Aug. 2005 to Sep. 2017 were retrospectively reviewed. Cumulative incidence of relapse (CIR), event-free survival (EFS) and overall survival (OS) rates were estimated by Kaplan-Meier method and prognostic factors were evaluated by Cox regression with SPSS.@*Results@#Of the 121 patients, 120 patients were assessed for bone marrow remission after induction chemotherapy. 100 cases (83.3%) achieved complete remission (CR) after the first course of chemotherapy. 119 cases (99.2%) achieved CR after the second course of chemotherapy. Of the 121 patients, 13 patients (10.7%) had recurrence with the median interval of recurrence as 13.8 months (3.7 to 58.8 months). 17 patients (14.0%) died. The CIR, EFS and OS at 3 years were 12.7%, 77.5% and 82.8%, respectively. The factors including age at diagnosis, sex, initial WBC count, presence of extramedullary leukemia, C-KIT expression, additional chromosomal abnormalities, and CR after the first course of chemotherapy were analyzed by multivariate regression analysis of Cox. Multivariate analysis identified that additional chromosomal abnormalities was the only independent risk factor affecting OS (HR=4.289, 95%CI 1.070-17.183, P=0.040).@*Conclusions@#Pediatric CBF-AML was a unique setting of prognostic subtypes. Chemotherapy produced good responses. Additional chromosomal abnormalities was the only independent risk factor for OS in pediatric CBF-AML.
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Objective@#To compare the visual quality after topography-guided customized femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and wavefront-optimized FS-LASIK treatment in myopic eyes.@*Methods@#A non-randomized controlled clinical study was performed.Seventy-eight eyes of 39 myopic patients undergoing FS-LASIK in Beijing Tongren Hospital from October 2016 to February 2017 were enrolled in this study and divided into two groups according to each patient's opinion, with matched demography between the two groups.Topography-guided customized FS-LASIK was performed on 42 eyes of 21 myopia in the topography-guided group, and wavefront-optimized FS-LASIK was performed on 36 eyes of 18 patients in the wavefront-optimized group.Visual acuity, refractive error, higher order aberrations (HOAs) and contrast sensitivity(CS) were compared between the two groups before and 6 months after surgery.Written informed consent was obtained from each patient before the operation.This study protocol was approved by Ethic Committee of Beijing Tongren Hospital (No.TRECKY2014-026).@*Results@#The postoperative uncorrected visual acuity (UCVA) levels were eaqual to or better than the preoperative best corrected visual acuity (BCVA) in 95.2% patients in the topography-guided group, and in 94.4% patients in the wavefront-optimized group 6 months after surgery, respectively.There were no significant differences in the spherical equivalent, sphere refraction and cylinder refraction between the two groups (all at P>0.05). The amount of induced coma was significantly lower in the topography-guided group than that in the wavefront-optimized group ([0.07±0.22]μm vs.[0.22±0.16]μm) at 6 mm pupil.LogCS improved under the 12.0 c/d in the background of mesopic in the topography-guided group and decreased under the 18.0 c/d both in the background of mesopic and mesopic + glare in the wavefront-optimized group 6 months after surgery, with signifcant differences between them (all at P<0.05). LogCS values under 6.0, 12.0 and 18.0 c/d in the background of mesopic and 18.0 c/d in the background of mesopic+ glare in the topography-guided group were significantly higher than those in the wavefront-optimized group 6 months after surgery, with significant differences between the two groups (all at P<0.05).@*Conclusions@#Topography-guided FS-LASIK has lower higher-order aberrations and better CS than wavefront-optimized FS-LASIK.
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En la actualidad existe una gran cantidad de información disponible en la red, principalmente en el ámbito científi-co. La velocidad a la que accedemos a la información hoy y las dimensiones de la misma es incomparable con los tiem-pos de antaño, es por esta razón que se hace indispensable identificar, clasificar y almacenar la información científica producida en el mundo. La producción científica se encuentra disponible en la internet, adicionalmente existe un acceso universal a la in-formación, incrementando las posibilidades de que nuestras publicaciones impacten en cualquier lugar del mundo, sin embargo, para que esto se produzca es necesario invertir en elementos adicionales que permitan realizar una adecuada gestión documental a nivel internacional, estos elementos hacen parte de una infraestructura digital intangible pero robusta en el mundo virtual y específicamente de las biblio-tecas y repositorios virtuales. Estos elementos son los meta-datos y los sistemas de identificación digital de objeto (DOI), en el camino a la internacionalización y modernización de la revista se ha realizado un gran esfuerzo en integrar esta infraestructura digital a cada uno de los artículos publicados, asegurando así la identificación del documento y a su vez la precisión en la referenciación o citación. Qué es el sistema DOI?: su nombre proviene del acró-nimo en inglés de "digital object identifier" y consiste en la generación un código o número único internacional que se vincula a cada manuscrito publicado en nuestra revista, es-pecíficamente a los meta-datos relacionados a cada artículo, permitiendo así que la producción científica producida con tanto esfuerzo no se pierda en la internert; por el contrario, logrará que los algoritmos de los motores de búsqueda y los métodos de medición del impacto científico por fin cuanti-fiquen adecuadamente nuestras publicaciones, aportando beneficios a los investigadores en primera instancia y final-mente a la revista.Continuando con la ruta trazada para lograr una adecua-da difusión de la investigación en Otorrinolaringología en Colombia y América Latina, nuestra revista se tecnifica y se pone a la vanguardia de los requerimientos de la ciencia ac-tual; esperamos que las mejorías en la infraestructura digital como la visualización e internacionalización de los artículos pubilcados a través de nuestro OJS, la generación de meta-datos y de números DOI a las publicaciones nos lleven por buen camino, el de mejorar nuestro impacto a nivel mundial.
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Trastorno Paranoide CompartidoRESUMEN
La revolución tecnológica que se ha presentado en las últimas décadas ha impactado la comunicación científica hasta transformarla radicalmente. Desde la búsqueda manual de información que implicaba revisar personalmente en un libro o una revista impresa a través de un índice bibliotecario, lo que hasta hace no mucho tiempo era el día a día en el proceso académico en ciencias de la salud, hasta bibliotecas virtuales con motores de búsqueda apoyados en inteligencia artificial que clasifican la información global de acuerdo a la relevancia y nivel de evidencia según el perfil profesional específico de cada usuario. Evidentemente nuestra revista no puede ser indiferente a ésta transformación global y muchos de estos cambios se están instaurando y consolidando, demostrado así un alto nivel de adaptación y resiliencia a las demandas del mundo actual. La principal herramienta tecnológica adoptada por nosotros en los últimos años es un sistema abierto de gestión y publicación de revistas, mas conocido en el mundo editorial como "OJS", el cual le permite a nuestras publicaciones entrar en la autopista de la información de manera organizada, libre y sistematizada, haciéndola mas visible y mejorando el potencial de citación o referenciación de los artículos.
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Humanos , Trastorno Paranoide Compartido , Organización y Administración , PublicacionesRESUMEN
Objective To propose a method for high-energy photon 3D decoding of PET detector to decode reactive crystal position and calculate γ ray depth in the scintillating crystal. Methods Light transmitting windows were set between the crystal arrays, visible photon groups were guided to distribute in the photoelectric sensor array during a single event, and sensor signal intensity was regulated to realize position and depth decoding of the high-energy photon.Monte Carlo method was used to compare the designs of different light transmitting windows to determine the effects of the crystal surface treatment mode on the results. Experiments were executed for further verification. Results The experimental results had consistency with simulation ones;the signal received through the reaction crystal was always stronger than that through the adjacent, which could decode the reaction crystals; the relations between the depth of interaction (DOI) and energy differences of the photo sensors were monotonic with the changes of DOI,and thus could be used to calculate the DOI;when using single window,the DOI vs.Diff.Energy curves had two segments which were not desired for DOI measurement;crystals with rough surfaces were more desired since the qualities of their DOI vs.Diff.Energy curves were better;the dual window method had the best DOI vs.Diff.Energy curves in term of linearity.Conclusion The method can realize 3D decoding of the discrete crystal array,which improves the energy resolution of the PET system. [Chinese Medical Equipment Journal, 2018,39(5):22-28,63]
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Background@#Myometrial invasion is one of the most important prognostic factors in the preoperative evaluation of patients with endometrial cancer. Several techniques have been used for the preoperative evaluation such as transvaginal ultrasound (TVS), magnetic resonance imaging (MRI) and computed tomography (CT). Transvaginal ultrasound has been shown to have comparable accuracy with MRI, cost effective and is widely available. @*Main Objective@#To determine the diagnostic accuracy of 2D transvaginal ultrasound in assessing myometrial infiltration by measuring the tumor free distance (TFD) and depth of invasion (DOI) among patients with endometrial cancer admitted for elective gynecologic surgery at Philippine General Hospital Department of Obstetrics and Gynecology.@*Methods@#This prospective validation study involved 49 patients with endometrial cancer admitted for elective surgery at the Department of Obstetrics and Gynecology of the Philippine General Hospital from October 1, 2016 to February 28, 2017. All patients had 2D transvaginal ultrasound at least within 1 week prior to schedule of surgery. The tumor free distance (TFD) and the depth of invasion (DOI) were prospectively measured and compared with the histopathologic result. Diagnostic accuracy in assessing myometrial infiltration by measuring the tumor free distance and depth of invasion through 2D transvaginal ultrasound were computed and test of association was done using 2x2 Fischer Exact test at 0.05? while AUC-ROC was plotted. @*Results@#The association between transvaginal ultrasound and final histopathology in assessing the myometrial infiltration was statistically significant (p=0.004). Moreover, the transvaginal ultrasound for assessing myometrial infiltration demonstrated 94.4% sensitivity and 43.8% specificity in detecting >50% infiltration wherein a likelihood would likely to occur by 1.68 times higher than those with <50% based on the final histopathology. Moreover, the accuracy values of TVS reflected in the AUC index were as follows, a TFD cut off value of ?0.82cm showed a higher sensitivity (46.88%) and specificity (100%) in predicting >50% myometrial infiltration while a DOI ratio of 0.50 is the cut off value which initiated a sensitivity (16.7%) and a higher specificity (75%) in predicting >50% infiltration. Finally, TFD (AUC = 0.749) yielded a higher accuracy as compared with DOI (AUC = 0.388) in predicting myometrial infiltration.@*Conclusion@#Assessment of myometrial infiltration by measuring the tumor free distance and depth of invasion through 2D transvaginal ultrasound among patients with endometrial cancer demonstrated clinically acceptable accuracy with higher sensitivity in detecting >50% myometrial infiltration. TFD (cut off value of ?0.82cm) has a higher accuracy compared with DOI in predicting >50% myometrial infiltration.
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Neoplasias EndometrialesRESUMEN
el diagnóstico de la tuberculosis ha estado basado en la detección directa de la micobacteria; sin embargo, se estima que este se puede lograr solamente en el 10% de los casos y requiere que se combine con métodos confirmatorios como el cultivo, el cual puede tomar varias semanas para que el crecimiento sea evidente. Los métodos basados en la amplificación de la secuencia ácidos nucleicos muestran sensibilidad y especificidad altas, pero no siempre son accesibles a todos los laboratorios debido a sus requerimientos de infraestructura y el costo de los insumos. Las limitaciones para el diagnóstico hacen que se busque continuamente metabolitos micobacterianos, mediante diferentes aproximaciones, que sean, ulteriormente, fáciles de rastrear en condiciones muy básicas de laboratorio. En esta revisión se incluyen algunas de las aproximaciones metodológicas basadas en la detección de derivados micobacterianos y su valor como herramienta para el rastreo de la micobacteria
The diagnosis of tuberculosis has been based on the direct detection of mycobacteria. However, it is estimated that only can be achieved in 10% of the cases and it is necessary to combine with confirmatory methods such as culture that may take several weeks to growth been evident. Methods based on sequence amplification of nucleic acids show high sensitivity and specificity, but are not always accessible to all laboratories due to infrastructure requirements and the cost of inputs. The limitations for the diagnosis induce to a continued research for mycobacterial metabolites by different approaches that are later easy to trace in very basic laboratory conditions. This review includes some of the methodological approaches based on mycobacterial derivatives and their value as a tool to detect the mycobacteria
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Humanos , Tuberculosis , Cromatografía , Factores Cordón , LípidosRESUMEN
Resumen La gestión de enfermedades inició en EE. UU. durante los años 70 y tuvo el fin de reducir la variabilidad de los procesos asistenciales y administrativos, controlar el gasto y mejorar la calidad de la atención. En lo corrido del presente siglo, se cuenta con una documentación amplia que permite realizar un balance sobre conceptos, componentes, metodologías y retos de los programas de gestión de enfermedades. Estos programas constituyen una práctica integradora e innovadora que permite involucrar a los distintos grupos de interés en su implementación y desarrollo. Tales grupos también se relacionan con los procesos de gestión y manejo de las enfermedades crónicas.
Abstract Disease management started in the U.S. during the 1970s in order to decrease variability in clinical and managerial processes, control costs, and improve the quality of attention. Throughout the 21st century, a growing body of literature has emerged allowing the assessment of concepts, components, methodologies and challenges of management disease programs. These programs have become into a unifying and innovative practice that allows involvement and coordination of different interest groups during implementation and development phases; such groups are also related to the management processes of chronic diseases.
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Graphis upretii is a new lichen species discovered in Vietnam. The species is characterized by a loosely corticate, rough, whitish grey to greyish green thallus, elongate and irregularly branched lirellae with an apically thin complete thalline margin (negrosina morph), laterally carbonized, entire proper exciple, clear hymenium, hyaline, 16~20 transversely locular ascospores, and about 50~95 x 10~15 microm in size. In addition, members of the taxon produce norstictic and stictic acids. Currently, the lichen flora of Vietnam include Arthonia radiata, Brigantiaea tricolor, Coenogonium implexum, Dirina paradoxa, Herpothallon sipmanii, Pertusaria pertusa, and Sarcographina cyclospora.
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Carbono , Clasificación , Cyclospora , Hialina , Líquenes , VietnamRESUMEN
Objective To analyze risk factors of elasticity of common femoral artery(CFA)and popliteal artery(PoA)in type 2 diabetic(T2DM)patients by echo-tracking(ET)technique.Methods Thirty healthy subjects(control group)and sixty-eight T2DM patients were enrolled in this study.The stiffness β of common femoral and popliteal artery were automatically measured by ET technique.The differences in ordinary and biochemical indices between control group and T2DM group were compared and analyzed by the method of linear regression and multiple linear regression.Results In both control and the T2DM group,β of CFA and PoA were significantly correlated with age,systolic blood pressure.TC, LDL,ApoB and LPa of CFA were also significantly correlation with β in T2DM group(P<0.05).Conclasions The stiffness of CFA and PoA in patients with T2DM increased followed by the increase of age, systolic blood pressure,TC,VLDL,ApoB and LPa.
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Objective To assess the clinical value of laparoscopic colorectal resection combined with simultaneous radiofrequency ablation for liver metastases.Methods Twenty-two patients with colorectal cancer and synchronous liver metastases were treated by laparoscopie colorectal resection and simultaneous radiofrequency ablation(RFA)in Third People's Hospital of Chengdu from December 2001 to July 2006.Areas of colliquative necrosis were detected by contrast-enhanced computed tomography postoperatively.The outcomes were analyzed by chi-square test.Results Of all patients,8 had muhiple liver metastases,16 had complications.Thirty-one liver metastases were treated by RFA,and no complication oecurred.The mean postoperative hospital stay was(14±5)days,and there was no perioperative death.Five of the 22 patients were identified as incomplete ablation of the tumor,and the RFA was reperformed.The recurrence of liver metastases in the RFA necrotic zone was observed in 4 patients,and RFA was reperformed on 2 of them.Six patients died,and 2 of them died of liver metastases recurrence in the RFA necrotic zone.The recurrence rate of liver metastases and mortality was 18%(4/22)and 27%(6/22),respectively.The recurrence rate of patients with the diameter of the metastatic lession≥2.0 cm was significantly higher than those with the diameter of the metastatic lession＜2.0 cm(x2=5.867,P＜0.05).Conclusions Laparoseopie colorectal resection combined with simultaneous RFA provide a curative opportunity for colorectal cancer patients who are old and have multiple liver metastases,complications,poor tolerance of operation,and for patients whose tumors are difficult to resect.
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Objective To evaluate the effect of intervention on factors influencing the health service utility regarding Maternal and Child Health (MCH)under the 'Qinba Health Project' in Sichuan province. Methods 15 towns in 5 programmed counties were selected, using the method of 'random layer sampling' to be the trial group. With similar MCH status and comparable to the trial group, another 9 towns in 3 non-programmed counties were chosen as the control group, using the same sampling method. Indicators on MCH service utility were compared with that in the control group, and the influencing factors of MCH service utility analyzed by logistic model. Results The main characteristics of the two groups were quite similar at the baseline study, with the average annual family incomes and MCH service per 1000 people. Annual input on MCH services from the government had an distinct increase. The average annual rates of increase regarding the indictors as clean delivery, hospitalized delivery, systematic care on maternal and children, maternal and infant mortality rates were: 1.95%, 9.34%, 4.82%, 3.04%, -2.67%, -13.84% (P<0.02) through χ2 trend tests. In the trial group, the changes seen in the 6 indicators were better in the control group than in the control group(P<0.05). Data from the logistic regression model showed that the major influencing factors on the use of hospitalized delivery service were: age of the pregnant woman, average annual income of the family, health insurance status, number of pre-delivery visits, whether on poverty alleviate program, and on knowledge of MCH. Conclusion The intervention project in this programmed area seemed effective and better than the non-programmed area, through an eight-year observation.