RESUMEN
Objective To identify the active metabolites of Penicillium sp. H1 isolated from Beibu Gulf of Guangxi. Methods The isolation and purification of compounds were performed by means of column chromatography with silica gel. And their structures were elucidated through the analysis of UV, MS, NMR, and specific rotations. The bioactivities of compounds against Fusarium oxysporum f. sp. cubense were assayed by paper diffusion. Results Three diterpenes (1—3) were isolated from the fermentation broth of Penicillium sp. H1. Compound 1 was identified as a new compound and named xylarinonericin D. Compounds 2 and 3 were identified as BE-31405 (2) and sordaricin (3), respectively. Compounds 1 and 2 showed moderate antifungal activity against Fusarium oxysporum f. sp. cubense with MIC values of 32.0 μg/mL and 16.0 μg/mL, respectively. Conclusion Compound 1 is a new diterpene glycoside.
RESUMEN
Objective: To study the diterpenes in the roots of Rabdosia japonica var. glaucocalyx. Methods: The constituents of R. japonica var. glaucocalyx were separated and purified with chromatographic methods, and their structures were elucidated by spectroscopic methods. Results: Two compounds were isolated from the roots of R. japonica var. glaucocalyx, and they were identified as glaucocalyxoside (1) and inflexuside A (2). Conclusion: Compound 1 is a new abietane diterpene glycoside named glaucocalyxoside, and compound 2 is isolated from R. japonica var. glaucocalyx for the first time.