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Pulmonary arterial hypertension (PAH) is characterized hemo-dynamically by the presence of pre-capillary pulmonary hypertension, defined by a pulmonary artery wedge pressure (PAWP) ≤15 mmHg and a pulmonary vascular resistance(PVR)>3 wood units (WU). According to the current classification, PAH can be associated with exposure to certain drugs or toxins such as anorectic agents, amphetamines, or selective serotonin reuptake inhibitors. The improvement in awareness and recognition of drug-induced PAH (DIPAH) have allowed the identification of more drugs associated with an increased risk for induction of PAH. The supposed mechanism is the increase of the serotonin level or activation of serotonin receptors that have been demonstrated to promote the growth of pulmonary artery smooth muscle cells and cause progressive obliteration of pulmonary vascular. DIPAH remains a rare complication, which may be associated with individual susceptibility, and further studies are needed to identify patients at risk of DIPAH.
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ObjectiveTo study the occurrence and influence factors of drug-induced injuries of vital organs caused by traditional Chinese medicine injection.MethodsChina Hospital Knowledge Database (CHKD) from 1993-2013 and case reports concerning adverse effects and drug-induced diseases caused by traditional Chinese medicine injection from Wanfang Data Knowledge Service Platformwere retrieved. Indicator systemwasestablished and relevant contentsweresummarized and analyzed.Results34 types of traditional Chinese medicine injectionswereincluded and 699 drug-induced diseasesweresummarized, taking up 53.98% of the total adverse effects. Among them, the top three included in the drug-induced diseaseswere acanthopanax injection, safflower injection and Mailuoning injection. The non-conformance between the traditional Chinese medicine injections in the literature and instructions mainly reflects unreasonable solvent selection, large compatibility concentration and usage and dosage beyond those specified in the instructions. ConclusionThe occurrence of drug-induced injuries of vital organs caused by traditional Chinese medicine injectionis relatively high, drug instructions shall be strictly followed in accordance with requirements during clinical application.
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Objective:To explore the role of clinical pharmacists in the diagnosis and treatment of drug-induced diseases. Meth-ods:Clinical pharmacists analyzed the abnormal changes in the patients and looked for drug factors during the ward round with physi-cians. Results:Clinical pharmacists found drug-induced diseases and irrational drug use, and proposed the solutions accepted by phy-sicians. Conclusion:Clinical pharmacists should actively participate in the diagnosis and treatment of drug-induced diseases.
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OBJECTIVE:To discuss the general regularity and characteristics of the drug-induced edema so as to provide reference for clinical safe medication.METHODS:173 drug-induced edema cases publicly reported in domestic journal from 2001 to 2006 were analyzed statistically.RESULTS:The drug-induced edema was more often seen in males than in females,but not linked to age.It was characterized by early onset,with 76(43.9%)showing edema within 1h.It was chiefly induced vial oral and intravenous routes.The drug-induced edema was caused by 17 drug categories(or 115 kinds),with antibacterials showing the highest percentage(31.2%,54 cases).Laryngeal edema,which occurred in 57 cases,was the chief type among all the edema cases.CONCLUSION:Drug-induced edema is a common adverse drug reaction,which should be given great attention in the clinic,much as in the case of acute laryngeal edema.Clinicians should give close monitoring on patients after medication to guard against possible events.
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OBJECTIVE: To discuss the general regularity and the characteristics of the drug-induced edema caused by traditional Chinese medicine injections (TCMI) so as to provide basis for rational drugs use in the clinic. METHODS: 61 cases of drug-induced edema caused by TCMI publicly reported in domestic journal from 1994 to 2007 were analyzed statistically. RESULTS: The drug-induced edema caused by TCMI was not linked to sex and age. The symptom appeared in a short period and edema was induced in 44 cases within 30 min (72.1%). Laryngeal edema accounted for 54.1% and ocular angioedema 34.4%. 23 kinds of TCMI were involved, among which top 5 drugs in the list of incidence were Qingkailing injection, Shuanghuanglian injection, Yuxingcao injection, etc. CONCLUSION: Great importance should be attached to the monitoring of the clinical use of TCMI to promote the safety of TCMI.