Governor vessel moxibustion combined with western medication for mild to moderate depression with kidney-yang deficiency: a randomized controlled trial / 中国针灸

OBJECTIVE@#To compare the therapeutic efficacy of governor vessel moxibustion combined with fluoxetine hydrochloride capsule, simple fluoxetine hydrochloride capsule and placebo moxibustion combined with fluoxetine hydrochloride capsule for mild to moderate depression with kidney-yang deficiency.@*METHODS@#A total of 126 patients with mild to moderate depression with kidney-yang deficiency were randomized into a governor vessel moxibustion group (42 cases, 2 cases dropped off), a western medication group (42 cases, 1 case dropped off) and a placebo moxibustion group (42 cases, 1 case dropped off). The western medication group was given fluoxetine hydrochloride capsule orally, 20 mg a time, once a day. On the basis of the treatment in the western medication group, governor vessel moxibustion was applied from Dazhui (GV 14) to Yaoshu (GV 2) in the governor vessel moxibustion group, once a week; placebo moxibustion was applied in the placebo moxibustion group, once a week. Treatment of 8 weeks was required in the 3 groups. Before and after treatment, the scores of Hamilton depression scale-17 (HAMD-17), Asberg's rating scale for side effects (SERS) and TCM clinical symptom were compared, and the clinical efficacy was evaluated.@*RESULTS@#After treatment, the scores of HAMD-17, SERS and TCM clinical symptom were decreased compared before treatment in the 3 groups (P<0.05), the decrease ranges of above scores in the governor vessel moxibustion group were larger than those in the western medication group and the placebo moxibustion group (P<0.05). The total effective rate was 92.5% (37/40) in the governor vessel moxibustion group, which was higher than 75.6% (31/41) in the western medication group and 80.5% (33/41) in the placebo moxibustion group (P<0.05).@*CONCLUSION@#Governor vessel moxibustion combined with fluoxetine hydrochloride capsule can improve the degree of depression and relieve the clinical symptoms in mild to moderate depression patients with kidney-yang deficiency, the efficacy is superior to simple fluoxetine hydrochloride capsule, and can reduce the fluoxetine hydrochloride capsule-induced adverse effect to a certain extent.

Impairment of C ognition in patients of B ipolar disorder in E uthymia in Indian population

Background: Bipolar disorder is one of the common mental disorders(CMD) in India. It leads to significant cognitive deficit even during the period of euthymia. So, it is important to identify the various cognitive deficits in euthymic bipolar disorder patients in Indian population. Methods: The study was conducted over a period of 2 years in AIIMS Jodhpur, Rajasthan. 30 cases and 30 controls were selected. Cases were selected by administering Hamilton dep ression rating scale (HAM - D) and Young mania rating scale (YMRS) to the bipolar disorder patient, recruited from Psychiatry OPD, to select the patients who were in euthymia. Cognitive domains such as attention, memory, fluency, language and Visuospatial we re tested in both the groups and compared. Kruskal - Wallis test was employed to compare the 2 sample groups for different variables. In this study we wanted to observe the decline in cognitive function in healthy vs euthymic bipolar disorder patients and to know the various domains of cognition that are affected. Results: This study shows a presence of cognitive decline in euthymic bipolar disorder patients as compared to controls. A significant difference was found in all the cognitive domains namely atte ntion, memory, fluency, language and visuospatial between cases and controls. Conclusion: This study shows a positive correlation between cognitive decline and bipolar patients during the period of euthymia. This suggests that even though the bipolar disor der patient is in remission, there is still a residual effect on cognition during euthymic state which can eventually affect the day to day life and can hamper the quality of life.

CT parameter changes and imaging analysis of each cerebral lobe in patients with monophasic depression / 中国基层医药

Objective:To analyze the imaging changes of patients with monophasic depression based on the changes in CT parameters of each cerebral lobe.Methods:A total of 100 patients with monophasic depression who received treatment in Department of Radiology, Shaoxing 7 th People's Hospital between June 2019 and June 2021 were included in the observation group. An additional 100 healthy individuals who concurrently received physical examination were included in the control group. CT scan of the brain was performed in all participants. CT value of each cerebral lobe was compared between the two groups. Results:CT values of the left frontal lobe and left temporal lobe in the observation group were (40.88 ± 2.01) HU and (40.21 ± 3.01) HU, respectively, which were significantly lower than those in the control group ( tleft frontal lobe = 2.94, P = 0.004; tleft temporal lobe = 3.29, P = 0.001). CT values of the right frontal lobe and right temporal lobe in the observation group were (40.09 ± 2.52) HU and (44.93 ± 3.03) HU, respectively. There were no significant differences in CT values of the right frontal lobe and right temporal lobe between the two groups ( tright frontal lobe = 1.89, P = 0.060; tright temporal lobe = 1.89, P = 0.060). There were no significant differences in CT values of the left and right occipital lobes and the left and right parietal lobes between the two groups (all P > 0.05). One-way analysis of variance revealed that the CT values of the left and right frontal lobes were negatively correlated with age (-0.441, -0.211) and course of disease (-0.445, -0.191) (both P < 0.05); the CT values of the left and right frontal lobes were not significantly correlated with 24-item Hamilton Depression Rating Scale score and the number of attacks (all P > 0.05). The CT values of the left and right temporal lobes (-0.207, -0.213), the left and right occipital lobes (-0.185, -0.195) and the left and right parietal lobes (-0.185, -0.180) were negatively correlated with age (all P < 0.05). The CT values of the left and right temporal lobes, the left and right occipital lobes, and the left and right parietal lobes were not significantly correlated with course of disease, 24-item Hamilton Depression Rating Scale score, and the number of attacks (all P > 0.05). Conclusion:The left and right frontal lobe and the left temporal lobe are atrophic in patients with monophasic depression. The degree of atrophy is closely related to the course of disease. Therefore, these findings can be used as a reference for imaging diagnosis of degenerative diseases of the central nervous system.

Mild and moderate postpartum depression treated with acupuncture of / 中国针灸

OBJECTIVE@#To observe the clinical therapeutic effect on mild and moderate postpartum depression treated with acupuncture of @*METHODS@#A total of 116 patients with mild and moderate postpartum depression were divided into an acupuncture group (103 cases) and a non-acupuncture group (13 cases) according to treatment regimen provided. In the acupuncture group, acupuncture of @*RESULTS@#The total effective rate of the acupuncture A group was 100.0% (31/31), better than 76.9% (10/13) in the non-acupuncture group and 58.1% in the acupuncture B group (18/31) (@*CONCLUSION@#Acupuncture of

Association between quality of life and clinical symptoms in patients with the first-episode depression / 西安交通大学学报(医学版)

【Objective】 To study the relationship between quality of life and clinical symptoms of patients with the first-episode depression. 【Methods】 The untreated patients (n=36) with the first-episode depression and the depression patients (n=71) on drug treatment were included according to the strict screening and exclusion criteria. Subjects in control group (n=59), who matched in age, gender and education, were included according to the corresponding enrollment criteria. World Health Organization Quality of Life—Brief (WHOQOL-BREF) and The Social Adaptation Self-evaluation Scale (SASS) were used to evaluate all the subjects. The Hamilton Depression Rating Scale (HAMD), The Hamilton Anxiety Scale (HAMA) and Montgomery-Asberg Depression Rating Scale (MADRS) were used to evaluate the depressive patients. 【Results】 There was no significant difference in age or education level between all the groups. The quality of life was significantly lower in the first group and the treatment group than in the control group; no significant difference was found between patients in the two depression groups. Correlation analysis showed that the total scores of physiology, environment and quality of life in the first group and the treatment group were negatively correlated with HAMD, HAMA and MADRS. SASS was positively correlated with the total scores of physiology, psychology, environment and quality of life. 【Conclusion】 The quality of life and social adaptation of patients with the first-episode depression and those with depression after treatment were significantly reduced. More serious depression symptoms are linked to the worse quality of life, while better social adaptation is linked to the better quality of life.

Prevalence of depression and quality of life in polycystic ovary syndrome patients at a tertiary care hospital: a cross-sectional study

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathy among women of reproductive age. Physical symptoms in PCOS cause depression and decrease the Quality of Life (QoL). The objective was to study the prevalence of depression in women suffering from PCOS and to assess its correlation with QoL.Methods: This was a cross sectional study conducted among one hundred patients diagnosed with PCOS. Women 18-40 years of age diagnosed with PCOS were included in the study. Patients with known psychiatric illness were excluded. Depression severity was assessed with Hamilton depression (HAM-D) scale. The quality of life (QoL) was assessed with Polycystic ovary syndrome questionnaire (PCOSQ). The data was analyzed using SPSS 20.0 for Windows.Results: The mean age and BMI was 25.64±3.25 years and 26.78±2.72 kg/m2 respectively. The mean depression score was 12.46±6.18. QoL domains showed that the lowest score was in the menstrual problem with a mean of 12.48±4.44 and the highest was in the emotional domain with a mean of 28.07±11.17. The negative correlations were between age and Hamilton score (p < 0.05). The Hamilton score was negatively correlated with the emotional score (p <0.01) and weight score was positively correlated with infertility score (p <0.01).Conclusions: PCOS was clearly associated with depression and reduced QoL. This should warrant health professionals to consider routine screening for depression and assess the impact of symptoms on their QoL to improve patient outcomes.

Clinical Observation of Flupirtine Maleate Combined with Amitriptyline in the Treatment of Thalamic Pain after Stroke / 中国药房

OBJECTIVE:To observe the clinical efficacy and safety of flupirtine maleate combined with amitriptyline in the treatment of thalamic pain after stroke. METHODS:A total of 70 patients with thalamic pain after stroke in our hospital during Jan. 2016-Aug. 2017 were divided into control group(34 cases)and observation group(36 cases)according to random number table. Both groups received secondary prevention therapy of stroke. Based on it,control group was given Amitriptyline hydrochloride tablet 25 mg/time orally,tid. Observation group was additionally given Flupirtine maleate capsule 0.1 g/time orally,tid,on the basis of control group. Treatment course of 2 groups lasted for 4 weeks. VAS,HAMD17 and HAMA14 scores of 2 groups evaluated before treatment,after 1,2,3,4 weeks of treatment Clinical efficacies and the occurrence of ADR were observed in 2 groups. RESULTS:Before treatment,there was no statistical significance in the scores of VAS,HAMD17 or HAMA14 between 2 groups(P>0.05). VAS score and HAMD17 score of observation group after 1,2,3,4 weeks of treatment,those of control group after 2,3 and 4 weeks of treatment were significantly lower than before treatment;the observation group was significantly lower than the control group at different time periods(P<0.05 or P<0.01). HAMA14 score of 2 groups after 2,3,4 weeks of treatment were significantly lower than before treatment;the observation group was significantly lower than the control group at different time periods(P<0.05 or P<0.01). Total efficiency rate(91.67%)of observation group were significantly higher than that(67.65%)of control group(P<0.05). There was no statistical significance in the incidence of ADR between 2 groups (11.76% vs. 11.11%)(P>0.05). CONCLUSIONS:Flupirtine maleate combined with amitriptyline can effectively relieve thalamic pain after stroke,and improve post-stroke,anxiety depression,which are better than control group,and the incidence of ADR is familar to control group.

Effect of early acupuncture intervention on post-stroke depression: a randomized controlled trial / 中国针灸

OBJECTIVE@#To observe the effects of conventional drug therapy combined with acupuncture and conventional drug therapy on the morbidity of post-stroke depression and recovery of neurological function in patients with acute stroke, and provide new ideas for prevention and treatment of post-stroke depression.@*METHODS@#Sixty patients were randomly divided into an observation group and a control group, 30 cases in each one.Conventional drug therapy was given in the control group;on the basis of conventional drug therapy,acupuncture was applied at Baihui (GV 20), Sishencong (EX-HN1), Neiguan (PC 6), Hegu (LI 4), Taixi (KI 3), etc. The treatment was given once every day, 6 times a week for 4 weeks in the two groups. The 24 Hamilton depression rating scale (HAMD), modified Edinburgh-Scandinavian stroke scale (MESSS) scores were recored before treatment, after 1 week of treatment, and after 4 weeks of treatment in the two groups,and the morbidity of post-stroke depression was compared between the two groups.@*RESULTS@#After 1 week of treatment, the HAMD scale scores of the two groups were higher than those before treatment (both 0.05). The MESSS scores were lower than those after 1 week of treatment in the two groups (both <0.05), and the score in the observation group was significantly lower than that in the control group (<0.01). After 4 weeks of treatment, the morbidity of post-stroke depression in the observation group was 23.3% (7/30), which was lower than 66.7% (20/30) in the control group (<0.05).@*CONCLUSION@#Early acupuncture intervention on stroke patients can not only promote the recovery of neurological function, but also reduce the morbidity of post-stroke depression effectively.

Effects on female depression treated with the combined therapy of acupuncture and the five-element music therapy / 中国针灸

OBJECTIVE@#To observe the clinical effects and safety on female depression treated with the combined therapy of acupuncture and the five-element music therapy.@*METHODS@#A total of 120 female patients with depression were randomized into an electroacupuncture (EA) group, an acupuncture group, a five-element music therapy group and a group of the combined therapy of acupuncture and the five-element music therapy (combined therapy group), 30 cases in each one. In the EA group, the electric stimulation of acupuncture was applied at Baihui (GV 20), Shenting (GV 24), Neiguan (PC 6), Shenmen (HT 7), Sanyinjiao (SP 6) and Taichong (LR 3), with disperse-dense wave, 10 Hz/50 Hz, and 0.5 ms in wavelength. The needles were retained for 30 min. In the acupuncture group, the acupoints were same as the EA group, but without electric stimulation. In the five-element music therapy group, the music of tune was adopted in the treatment. In the combined therapy group, the acupuncture treatment and the five-element music therapy were same as the acupuncture group and the five-element music therapy group, in which the music therapy was followed after acupuncture treatment. The treatment was given once a day, at 2 days of interval after every 5 treatments in a week, totally for 8 weeks. The Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA) before and after treatment and the treatment emergent symptom scale (TESS) after treatment were observed in each group. The clinical effects and safety were compared among the groups.@*RESULTS@#The total effective rate was 86.7% (26/30) in the combined therapy group, better than 66.7% (20/30) in the EA group, 63.3% (19/30) in the acupuncture group and 53.3% (16/30) in the five-element music therapy group (<0.01, <0.05). After treatment, HAMD and HAMA scores were all reduced obviously in the patients of the 4 groups (all <0.01), and the scores in the combined therapy group were lower than the other 3 groups (all <0.01). The TESS score in the combined therapy group was lower than the other 3 groups (all <0.01) and the score in the five-element music therapy group was lower than the EA group and the acupuncture group (both <0.01).@*CONCLUSION@#In the female patients, the combined treatment with acupuncture and the five-element music therapy obviously reduces the severity of depression and anxiety, as well as the adverse reactions. The effects are better than the simple application of EA, acupuncture or music therapy.

Clinical Observation of Jie Yu Tong Fu Needling for Depression Coupled with Constipation / 上海针灸杂志

Objective To observe the clinical efficacy of Jie Yu Tong Fu (anti-depression and unblocking Fu-organs) needling in treating depression coupled with constipation. Method Sixty-four eligible patients with depression accompanied by constipation were recruited and randomized into a treatment group and a control group at 1:1. Each group had 2 dropout cases, and finally there were 30 complete cases in each group. The treatment group was intervened by Jie Yu Tong Fu needling by selecting Baihui (GV20), Yintang (GV29), Shenmen (HT7), Neiguan (PC6), Hegu (LI4), Sanyinjiao (SP6), Taichong (LR3), Tianshu (ST25), Zusanli (ST36) and Shangjuxu (ST37); the control group was intervened by sham acupuncture. The two groups were treated 3 times a week, for successive 8 weeks, 24 sessions in total. The two groups were evaluated by adopting Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Patient Assessment of Constipation-Symptoms (PAC-SYM) before the intervention, after 4-week and 8-week intervention, and 4 weeks after the whole intervention. Result Before the intervention, there were no significant between-group differences in the scores of HMAD, HAMA and PAC-SYM (P>0.05). The treatment group showed significant improvements in HAMD, HAMA and PAC-SYM scores after 4-week and 8-week treatment, as well as in the 4-week follow-up study compared to the scores before the treatment, and the improvements were more significant than those in the control group (P<0.01,P<0.05). The total effective rate was 90.0% in the treatment group, versus 66.7% in the control group. Conclusion Jie Yu Tong Fu needling can effectively ameliorate the depression and anxiety state and constipation-related symptoms in depression patients.

Characteristics of cognitive dysfunction in essential tremor patients / 西安交通大学学报(医学版)

Objective To explore the characteristics and influencing factors of cognitive dysfunction in patients with essential tremor (ET).Methods We recruited ET patients diagnosed by the Department of Neurology of the First Affiliated Hospital of Xi`an Jiaotong University and healthy volunteers who matched the ET patients in age, gender and education level for the study.We recorded all the patients` demographic information, tremor degree, and family history based on the family tree.All the participants were tested by MMSE, MoCA, ADL, HAMD and HAMA.Results There were 88 ET patients and 63 normal subjects included in the study.According to MMSE, 31.82％ of the patients had cognitive dysfunctions, with orientation, short-term memory, calculation ability, language skills, retelling, reading comprehension, three-level command and drawing being significantly lower than those of the healthy volunteers (P<0.01);orientation was the most serious damage in cognitive function domain (K=0.624, S=0.726);three-level command was the least serious damage (K=0.274, S=0.319).According to MoCA, 86.36％ of the ET patients had cognitive dysfunction higher than normal people (P<0.05);visual space and execution, clock drawing task, naming, attention, 100-7, language skills, abstract thinking and orientation were significantly lower than normal people (P<0.01);the most serious damage in cognitive function domain was visual space and execution (K=0.651, S=0.786); the least serious damage cognitive function domain was “100-7” (K=0.406, S=0.484). Education level and age affected cognitive dysfunction (P<0.05). ADL scores showed negative correlation with cognitive function (correlation =－0.375 and －0.383, respectively; P<0.001). After the effects of anxiety and depression were excluded, onset age and tremor grading were correlated with cognitive dysfunction (P<0.05). When the above factors were put into binary Logistic regression model, education level was found to be contributed to the model (P<0.05).Conclusion Patients with ET widely suffer from cognitive impairment. Age, education level, daily life disability, age of onset, and tremor degree classification can affect cognitive dysfunction.

Clinical Observation of Acupuncture plus Hyperbaric Oxygen for Depression After Cerebral Stroke / 上海针灸杂志

Objective To observe the clinical efficacy of acupuncture plus hyperbaric oxygen in treating depression after cerebral stroke.Method A total of 120 patients with depression after cerebral stroke were randomized into a treatment group of 60 cases and a control group of 60 cases. The treatment group was intervened by acupuncture plus hyperbaric oxygen, while the control group was intervened by Fluoxetine. Before the treatment, and respectively after 14-d and 28-d treatments, the patients were evaluated by Hamilton Depression Scale (HAMD) and National Institute of Health Stroke Scale (NIHSS), and the therapeutic efficacies were compared between the two groups. Result The treatment group was significantly superior to the control group in comparing therapeutic efficacy (P<0.01). After 1 course of treatment, the HAMD and NIHSS scores dropped significantly in the treatment group (P<0.01); the scores in the control group showed a declining tendency but without statistical significances (P>0.05). After 2 treatment courses, the HAMD and NIHSS scores were significantly different from those before the treatment in both groups (P<0.01), and the differences were more significant in the treatment group (P<0.01).Conclusion Acupuncture plus hyperbaric oxygen is effective in treating depression after cerebral stroke, and it can obviously improve the neural function.

Clinical Observation of Acupuncture plus Hyperbaric Oxygen for Depression After Cerebral Stroke / 上海针灸杂志

Objective To observe the clinical efficacy of acupuncture plus hyperbaric oxygen in treating depression after cerebral stroke.Method A total of 120 patients with depression after cerebral stroke were randomized into a treatment group of 60 cases and a control group of 60 cases. The treatment group was intervened by acupuncture plus hyperbaric oxygen, while the control group was intervened by Fluoxetine. Before the treatment, and respectively after 14-d and 28-d treatments, the patients were evaluated by Hamilton Depression Scale (HAMD) and National Institute of Health Stroke Scale (NIHSS), and the therapeutic efficacies were compared between the two groups. Result The treatment group was significantly superior to the control group in comparing therapeutic efficacy (P<0.01). After 1 course of treatment, the HAMD and NIHSS scores dropped significantly in the treatment group (P<0.01); the scores in the control group showed a declining tendency but without statistical significances (P>0.05). After 2 treatment courses, the HAMD and NIHSS scores were significantly different from those before the treatment in both groups (P<0.01), and the differences were more significant in the treatment group (P<0.01).Conclusion Acupuncture plus hyperbaric oxygen is effective in treating depression after cerebral stroke, and it can obviously improve the neural function.

A control study of cognitive function in patients with treatment-resistant depression and first-episode depression / 天津医药

Objective To compare the cognitive functions between patients with treatment-resistant depression and first-episode depression. Methods A total of 80 major depressive disorder patients admitted in our hospital from March 2015 to December 2016 were included in this study. The patients were divided into treatment-resistant depression group (n=40) and first-episode depression group (n=40). Another 40 healthy individuals were used as the control group. The basic data of patients were collected, and Hamilton depression scale (HAMD)-17 was used to assess the severity of the disease. The performing functions were assessed by trail marking test and stroop color-word test. The attention functions were assessed by digital span test. Memory functions were assessed by Hopkins verbal learning test revise (HVLT-R). After treatment for 6 months, cognitive functions were assessed again in first-episode depression group. Results Compared with control group, the scores of trail marking test (TMT) increased, while the scores of digital span test, stroop color-word test, stroop color-colorword test, HVLT-R reduced in treatment-resistant depression group and first-episode depression group ( P<0.05). The scores of TMT, HAMD-17 were lower in first-episode depression group than those of treatment-resistant depression group (P < 0.05). There were no significant differences in other indexes between groups. After six months treatment, the trail marking test score and HAMD-17 reduced, but digital span test, stroop color-word test increased in first-episode depression group (P<0.05). Conclusion The cognitive function damages severely in patients with treatment-resistant depression and first-episode depression, but there is no obvious difference in severity between two groups of patients.

Effect of Acupuncture plus Medication on HAMD, SDS and H-P-O Axis in Perimenopausal Depression Patients / 上海针灸杂志

Objective By observing the clinical efficacy of acupuncture plusBu Shen Jie Yu Qing Xin decoction (herbal decoction for tonifying kidney, anti-depression and clearing heart fire) in treating perimenopausal depression, to discuss about the effect of acupuncture plus medication on Hamilton Depression Scale (HAMD), Self-rating Depression Scale (SDS) and hypothalamic-pituitary-ovarian (H-P-O) axis in perimenopausal depression patients.Method By following a completely randomized design, sixty perimenopausal depression patients were divided into a Chinese medication group (Bu Shen Jie Yu Qing Xin decoction) with 30 cases, and an acupuncture-medication group (acupuncture plusBu Shen Jie Yu Qing Xin decoction) with 30 cases, to receive 12-week treatment in total. The HAMD and SDS were estimated prior to the treatment and in the 4th, 8th and 12th weeks; the serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), prolactin (PRL), and progesterone (P) contents were detected before and after the treatment.Result Acupuncture plus medication and Chinese medication alone were both effective in treating perimenopausal depression, and the therapeutic efficacy of acupuncture plus medication was superior to that of Chinese medication alone (P0.05). After 12-week treatment, the contents of FSH and LH declined significantly in both groups (P<0.01, P<0.05), and the contents of E2 and T increased significantly in the acupuncture-medication group (P<0.01,P<0.05). The decrease of FSH and LH, and the increase of E2 were more significant in the acupuncture-medication group (P<0.05,P<0.01).Conclusion Acupuncture plus medication can improve the symptoms of perimenopausal depression, and it takes a faster action than Chinese medication alone. Acupuncture plus medication can mitigate 7 items in HAMD, while Chinese medication can improve anxiety, insight, sleep and despair. Acupuncture plus medication can produce a more significant efficacy in improving anxiety, insight, sleep, diurnal-nocturnal, obstruction, and body weight compared to Chinese medication. For perimenopausal depression, acupuncture plus medication can correct the endocrine disorder and improve depression state by down-regulating the levels of FSH and LH, and up-regulating the contents of E2 and T to improve the function of H-P-O axis.

Clinical Study of Yang Xue Rou Gan Needling in Treating Post-stroke Depression / 上海针灸杂志

Objective To evaluate the clinical efficacy of Yang Xue Rou Gan (blood-nourishing and liver-soothing) needling method in treating post-stroke depression. Method A total of 150 patients with post-stroke depression were divided into an observation group and a control group by using the random number table, 75 cases each. In addition to the same basic treatment, the control group was intervened by Fluoxetine hydrochloride, while the observation group received Yang Xue Rou Gan needling method, twice every day, 6 d as a course at 1-day interval, for 4 weeks in total. Before and after the intervention, 24-item Hamilton Depression Scale (HAMD), Modified Edinburgh-Scandinavian Stroke Scale (MESSS), and activities of daily living [ADL, Barthel Index (BI)] were evaluated. Result After the intervention, HAMD, MESSS, and BI scores were significantly changed in both groups (P<0.05), indicating that the two groups both had improvements in depression symptoms and signs; there were significant differences between the two groups (P<0.01), suggesting that the observation group had a more significant efficacy in treating depression. Conclusion Yang Xue Rou Gan needling method can notably improve the depression and neural deficit level in post-stroke depression patients.

Clinical Study on Paired Needling for Insomnia with Depression After Cerebral Stroke / 上海针灸杂志

Objective To observe the therapeutic efficacy of paired needling in treating insomnia with depression after cerebral stroke. Method Eighty patients with insomnia plus depression after cerebral stroke were randomized into a treatment group and a control group, 40 cases in each group. The treatment group was intervened by paired needling at Xinshu (BL15), Juque (CV14), Ganshu (BL18), and Qimen (LR14), once a day, 20 min each session;the control group was by oral administration of Paroxetine hydrochloride tablet 20 mg, 1 tablet each time prior to sleep at night. Two treatment courses were observed in the two groups (successive 2-week treatment as a course). The Pittsburgh Sleep Quality Index (PSQI) was adopted to observe the two groups before treatment, after 2-week treatment, and after 4-week treatment, and the clinical efficacy was also evaluated. Result Respectively after 2-week and 4-week treatment, the PSQI scores and Hamilton Depression Scale (HAMD) scores dropped significantly in the two groups compared to that before the intervention (P<0.05);the improvements of the PSQI and HAMD scores in the treatment group were more significant than that in the control group;the scores were markedly improved in the 2nd week in the treatment group and were significantly different from that in the control group (P<0.05);the significant differences were maintained in the following 2 weeks;the total effective rate was respectively 90.0%(36/40) in the treatment group and 15.0%(6/40) in the control group, and the therapeutic efficacy of the treatment group was markedly superior to that of the control group (P<0.05). Conclusion The results show that paired needling is safe and effective in treating insomnia with depression after cerebral stroke, and its therapeutic efficacy is superior to that of Paroxetine hydrochloride tablets.

Therapeutic Observation of Electroacupuncture at Different Frequencies for Post-stroke Depression / 上海针灸杂志

Objective To observe the clinical efficacy of electroacupuncture at different frequencies in treating post-stroke depression. Methods A hundred patients with post-stroke depression were randomized into treatment group 1, treatment group 2, treatment group 3, and a control group, 25 in each group. The treatment groups were intervened by electroacupuncture, while 2 Hz was adopted in treatment group 1, 50 Hz in treatment group 2, and 100 Hz in treatment group 3. The control group was intervened by oral administration of Sertraline Hydrochloride tablets. The Function Independent Measure (FIM) and Hamilton Depression (HAMD) scale were adopted for observation before and after intervention, and the clinical efficacies were compared. Results The FIM and HAMD scores were significantly changed after intervention in the four groups (P<0.05). After treatment, the FIM and HAMD scores in treatment group 1 were significantly different from that in treatment group 2 and 3 (P<0.05). The FIM score in treatment group 1 was significantly different from that in the control group (P<0.05). The total effective rate was 96.0%in treatment group 1, versus 92.0%in treatment group 2, 82.0%in treatment group 3, and 84.0%in the control group. The total effective rate in treatment group 1 was significantly different from that in the control group (P<0.05). Conclusions Electroacupuncture at 2 Hz, 50 Hz, and 100 Hz all can improve the activities of daily living and depression degree in patients with post-stroke depression, while 2 Hz ranks the top in comparing the therapeutic efficacy.

Clinical effectiveness observation of manipulation in treating early perimenopausal depression / 中国基层医药

Objective To observe the clinical effectiveness of manipulation combined psychological counse-ling in treating early perimenopausal depression.Methods 62 patients with early perimenopausal depression were selected,and randomized into the two groups according visiting sequence.The treatment group received manipulation combined psychological counseling therapy, and control group received fluoxetine therapy.The clinical effectiveness between two groups was compared.Results The total effective rate of the treatment and control group was 90.30%and 83.90%,respectively,there was significant difference between the two groups (P=0.707);the score of HAMD depression scale was (8.90 ±0.87)points vs (9.29 ±2.98)points post 6 weeks of therapy,and the score reduction rate was (53.74 ±2.86)points vs (51.95 ±15.03)points (t=-0.69,0.65;P=0.492,0.520,respectively).No obvious side adverse effect was seen in the treatment group,and nausea (5 cases),dizziness (4) and anorexia (7) was seen in the control group.Conclusion Manipulation combined psychological counseling therapy was similarly effective in treating early perimenopausal depression compared with fluoxetine,but associated with less adverse effect.

Effects of Acupuncture in Patients with Mild or Moderate Depression Treated with Paroxetine Hydrochloride / 中国中医药信息杂志

Objective To observe the clinical efficacy and reverse reactions of acupuncture combined with paroxetine hydrochloride in the treatment of mild or moderate depression. Methods The patients with mild or moderate depression (n=73) were randomly divided into control group (treated with paroxetine hydrochloride,n=33) and observation group (treated with acupuncture and paroxetine hydrochloride,n=40). The therapeutic course lasted for 6 weeks. The total score changes of Hamilton Depression Scale (HAMD) were observed before treatment and treated for 1, 2, 4 and 6 weeks. Rating Scale for Side Effects (SERS) was evaluated before treatment and treated for 2, 4, 6 weeks.Results The total effective rate of clinical efficacy in the observation group was 78.95% (30/38) and the control group was 68.75% (22/32), without significant difference between the two groups (P>0.05). The scores of HAMD decreased 4, 6 weeks after the treatment in the control group and 2, 4, 6 week after the treatment in the observation group compared with those in the same group before the treatment (P<0.05,P<0.01). There was a significant difference in HAMD scores between two groups after the treatment for 4 weeks (P<0.05). The scores of SERS showed a significant difference 4, 6 weeks after the treatment between the two groups (P<0.05).Conclusion Acupuncture can improve the curative effect of paroxetine hydrochloride and decrease its side effects in the treatment of depression.